An Engineered Protein−Au Bioplaster for Efficient Skin Tumor Therapy

Abstract

specificity in targeting melanoma cells and often harm surrounding healthy organs and tissues. [4,5] Besides, these conven tional therapies cannot effectively elimi nate tumors, thereby undertaking a high risk of recurrence. [6][7][8] The significant skin defects caused by surgery are also suscep tible to colonization by pathogenic bac teria, further leading to chronic wounds. On the other hand, multidrug resistance and autologous cell rejection are inevi table for emerging targeted therapies and immunotherapy. Alternatively, photo thermal therapies (PTT) have received tremendous attention for the treatment of tumors due to their minimal damage to tissues and low intrusiveness. [9][10][11][12][13] Nearinfrared (NIR) light has great tissue penetration depth, low autofluorescence, and absorption in the NIR region, which is suitable for melanoma's PTT treat ment. [14,15] Various NIRlightresponsive materials such as organic agents and inorganic nanoparticles (NPs) have been well investigated. [16][17][18] In particular, gold nanorods (GNRs) show exceptional optical absorption based on their tunable aspect ratios, which have served as promising photothermal agents in PTT due to their facile preparation, good biocompatibility, low toxicity, stable photothermal performance, and excellent photothermal con version efficiency. [19] Moreover, GNRs can lead to the covalent Melanoma is the most lethal malignancy in skin cancer and may occur at any site and express melanocytes. Due to malignant melanoma's invasion and migration nature, conventional therapies make it challenging to remove the whole tumor tissue while undertaking the high risks of tumor recurrence. Regarding the emerging targeted therapies and immunotherapy, drug resistance and low immunotherapeutic activity remain significant challenges. It is thus becoming urgently important to develop alternative strategies for melanoma therapy. Herein, a novel bifunctional protein-based photothermal bioplaster (PPTB) is developed for non-invasive tumor therapy and skin tissue regeneration. The complexation of adhesive protein and gold nanorods (GNRs) endow the obtained PPTB with good biocompatibility, controllable near-infrared (NIR) light-mediated adhesion performance, and high photothermal performance. Therefore, the PPTB bioagent facilitates skin adhesion and effectively transfers heat from skin to tumor. This behavior endows PPTB capability to eradicate skin tumors conveniently. Thus, the assembly strategy enables this hybrid bioplaster to hold great potential for skin-related tumor treatment.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202110062.

Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation

“…PTT is another phototherapeutic strategy, which employs photothermal materials to convert NIR laser into heat to treat disease 86 – 89 . The high temperature can eliminate tumors by melting the membrane of tumor cells and denaturing proteins 90 , 91 .…”

Biocompatible Inorganic Nanoagent for Efficient Synergistic Tumor Treatment with Augmented Antitumor Immunity

“…Thus, we obtained the core@shell structure of PBA@SiO 2 (Figures S3 and S4, Supporting Information). In order to introduce the function of glucose consumption [24] (glucose O g luconic acid H O ) and photothermal conversion [25,26] from gold nanoparticles, the exchange of the ligand with 3-aminopropyltriethoxysilane and a redox reaction with HAuCl 4 further resulted in the formation of PBA@SiO 2 -Au NPs. These PBA@SiO 2 -Au NPs showed a distinctive hierarchical hybrid structure and had a diameter of 142.4 ± 4.6 nm.…”

Advances in the Application of Nanomaterials to the Treatment of Melanoma

“…Additionally, Sutrisno et al designed a bifunctional composite scaffold, which had an excellent photothermal effect and could promote fibroblast proliferation and the extracellular matrix component gene expression of skin tissue regeneration [ 190 ]. Wei and co-workers have developed a novel protein-based bifunctional photothermal bioadhesive for non-invasive tumor treatment and skin tissue regeneration [ 191 ].…”