An enhanced sensing platform for ultrasensitive impedimetric detection of target genes based on ordered FePt nanoparticles decorated carbonnanotubes

Zhang, Wei; Zong, Peisong; Zheng, Xiuwen; Wang, Yunlong

doi:10.1016/j.bios.2012.10.052

Cited by 28 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conventional detection of nucleic acids is achieved on platforms such as single-walled carbon nanotubes, − graphene oxides, − and carbon and Au nanoparticles. − Although these materials function well to assay nucleic acids, their preparations are laborious and/or require high-cost instrumentation. , Therefore, current interests are focused on cost-effective and readily available materials. , In this regard, metal–organic frameworks (MOFs), readily prepared from metal ions/clusters and organic ligands, have captured widespread interest. − Some emissive MOFs have been demonstrated to be as powerful as fluorescent sensors for the detection of analytes. − It is a recent endeavor to use MOFs to selectively detect nucleic acids. − In 2013, Chen et al have demonstrated for the first time that a two-dimensional (2D) MOF Cu(H 2 dtoa) (H 2 dtoa = N , N ′-bis(2-hydroxyethyl)dithiooxamide) is effective and reliable for the detection of HIV-1 DNA sequences and thrombin . However, only a few MOFs have been so far explored for nucleic acid sensing in part because of their poor stability in biological media, − for example, in NaCl or MgCl 2 -containing Tris-HCl buffer solution.…”

mentioning

confidence: 99%

Platforms Formed from a Three-Dimensional Cu-Based Zwitterionic Metal–Organic Framework and Probe ss-DNA: Selective Fluorescent Biosensors for Human Immunodeficiency Virus 1 ds-DNA and Sudan Virus RNA Sequences

et al. 2015

View full text Add to dashboard Cite

We herein report a water-stable three-dimensional Cu-based metal-organic framework (MOF) 1 supported by a tritopic quaternized carboxylate and 4,4'-dipyridyl sulfide as an ancillary ligand. This MOF exhibits unique pore shapes with aromatic rings, positively charged pyridinium and unsaturated Cu(II) cation centers, free carboxylates, tessellating H2O, and coordinating SO4(2-) on the pore surface. Compound 1 can interact with two carboxyfluorescein (FAM)-labeled single-stranded DNA sequences (probe ss-DNA, delineated as P-DNA) through electrostatic, π-stacking, and/or hydrogen-bonding interactions to form two P-DNA@1 systems, and thus quench the fluorescence of FAM via a photoinduced electron-transfer process. These P-DNA@1 systems can be used as effective fluorescent sensors for human immunodeficiency virus 1 double-stranded DNA and Sudan virus RNA sequences, respectively, with detection limits of 196 and 73 pM, respectively.

show abstract

mentioning

confidence: 99%

Platforms Formed from a Three-Dimensional Cu-Based Zwitterionic Metal–Organic Framework and Probe ss-DNA: Selective Fluorescent Biosensors for Human Immunodeficiency Virus 1 ds-DNA and Sudan Virus RNA Sequences

et al. 2015

View full text Add to dashboard Cite

show abstract

“…4. The diameter of the semicircle in the Nyquist plot corresponds to the charge transfer resistance (R ct ) and the semicircle at higher frequency corresponds to electron-transfer-limited process [24]. The R ct of the carbon composite electrode (figure not shown) was lower than that of bare carbon may be because of the fabricated c-MWCNT has increased the electron transfer kinetics by increasing the conductivity of the working surface which resulted in decrease in the impedance [25].…”

Section: Differential Pulse Voltammetrymentioning

confidence: 99%

Carbon-Mercaptooctadecane/Carboxylated Multi-walled Carbon Nanotubes Composite Based Genosensor for Detection of Bacterial Meningitis

et al. 2013

View full text Add to dashboard Cite

Human brain bacterial meningitis is a lifethreatening disease mainly caused by Neisseria meningitidis, lead to several complications including damage of brain or even death. The present available methods for diagnosis of meningitis have one or more limitations. A rmpM gene based genosensor was fabricated by immobilizing 5 0 -amino modified 19-mer single stranded DNA probe onto carbonmercaptooctadecane/carboxylated multi-walled carbon nanotubes composite electrode and hybridized with 2.5-40 ng/6 lL of single stranded genomic DNA (ssG-DNA) of N. meningitidis from cerebrospinal fluid (CSF) of the suspected meningitis patients. The electrochemical response was measured by using cyclic voltammetry and differential pulse voltammetry (DPV) using 1 mM methylene blue as redox indicator in 30 min (including a response time of 1 min) at 25°C. The sensitivity of the genosensor was 3.762 (lA/cm 2 )/ng and limit of detection was 2 ng of ssG-DNA of N. meningitidis with DPV. The genosensor has specificity only to N. meningitidis and does not hybridize with the genomic DNA of any other possible pathogen in human CSF. The immobilization of the probe and hybridization of the ssG-DNA were characterized by using electrochemical impedance in presence of 5 mM potassium ferricyanide and scanning electron microscopy. The genosensor loses only 12 % of its original DPV current on storage at 4°C for 6 months. Carbon composite based electrochemical array can be constructed to detect multiple bacterial meningitis suspected patient CSF samples during an outbreak of the disease.

show abstract

“…This DNA electrochemical biosensor was extremely useful in distinguishing single-base or double-base mismatched sequences [5]. Furthermore, this procedure is straightforward as it does not necessitate advanced labeling of oligonucleotide probes [60].…”

Section: Acute Promyelocytic Leukemiamentioning

confidence: 99%

Electrochemical Biosensors in the Diagnosis of Acute and Chronic Leukemias

Allegra

Petrarca

Gioacchino³

et al. 2022

Cancers

View full text Add to dashboard Cite

Until now, morphological assessment with an optical or electronic microscope, fluorescence in situ hybridization, DNA sequencing, flow cytometry, polymerase chain reactions, and immunohistochemistry have been employed for leukemia identification. Nevertheless, despite their numerous different vantages, it is difficult to recognize leukemic cells correctly. Recently, the electrochemical evaluation with a nano-sensing interface seems an attractive alternative. Electrochemical biosensors measure the modification in the electrical characteristics of the nano-sensing interface, which is modified by the contact between a biological recognition element and the analyte objective. The implementation of nanosensors is founded not on single nanomaterials but rather on compilating these components efficiently. Biosensors able to identify the molecules of deoxyribonucleic acid are defined as DNA biosensors. Our review aimed to evaluate the literature on the possible use of electrochemical biosensors for identifying hematological neoplasms such as acute promyelocytic leukemia, acute lymphoblastic leukemia, and chronic myeloid leukemia. In particular, we focus our attention on using DNA electrochemical biosensors to evaluate leukemias.

show abstract

An enhanced sensing platform for ultrasensitive impedimetric detection of target genes based on ordered FePt nanoparticles decorated carbonnanotubes

Cited by 28 publications

References 18 publications

Platforms Formed from a Three-Dimensional Cu-Based Zwitterionic Metal–Organic Framework and Probe ss-DNA: Selective Fluorescent Biosensors for Human Immunodeficiency Virus 1 ds-DNA and Sudan Virus RNA Sequences

Platforms Formed from a Three-Dimensional Cu-Based Zwitterionic Metal–Organic Framework and Probe ss-DNA: Selective Fluorescent Biosensors for Human Immunodeficiency Virus 1 ds-DNA and Sudan Virus RNA Sequences

Carbon-Mercaptooctadecane/Carboxylated Multi-walled Carbon Nanotubes Composite Based Genosensor for Detection of Bacterial Meningitis

Electrochemical Biosensors in the Diagnosis of Acute and Chronic Leukemias

Contact Info

Product

Resources

About