An enzyme-free ultrasensitive electrochemical immunosensor for calprotectin detection based on PtNi nanoparticles functionalized 2D Cu-metal organic framework nanosheets

Dong, Lanlan; Yin, Li; Tian, Guozhen; Wang, Yongxia; Peng, Hua; Wu, Qiang; Cheng, Wei; Ding, Shijia; Xia, Qianfeng

doi:10.1016/j.snb.2020.127687

Cited by 52 publications

(28 citation statements)

References 25 publications

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“…In this study, the nanoparticle/MON hybrid structure exhibits enhanced electrocatalytic activity towards H 2 O 2 reduction, enabling them to act as signal amplifiers resulting in the highly sensitive detection of calprotectin down to 137.7 fg mL −1 . [140]…”

Section: Biological Moleculesmentioning

confidence: 99%

Metal–Organic Framework Nanosheets: Programmable 2D Materials for Catalysis, Sensing, Electronics, and Separation Applications

Nicks¹,

Sasitharan²,

Prasad³

et al. 2021

Adv Funct Materials

115

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offers advantages over simple inorganic nanosheets in that a diverse range of physical and chemical properties can be programmed into their crystalline structure (Figure 1). This distinct combination of properties makes MONs ideal for a wide range of catalysis, sensing, electronics, and separation applications which will be the focus of this review.Much of the early literature in this field focused on the development of novel MON architectures and new routes towards their synthesis. A diverse range of different metal ions and organic linkers have been used to construct MONs. [4] However the field has rapidly converged on a handful of popular secondary building units (SBUs) which dominate much of the literature thanks to their reliable formation of high aspect ratio nanosheets. Popular classes of MONs that have been widely applied by different groups in applications include those based on the metal paddlewheel (PW) motif, [5][6][7] axially capped Zr and Hf clusters, [8][9][10][11] 2D zeolitic imidazolate frameworks (ZIFs), [12][13][14] and square planar Ni, Co, and Cu SBUs. [15][16][17][18] The modular structure of MONs, ease of functionalization and diverse range of materials they can be combined with means that MONs can be readily "programmed" to provide the desired topology and properties required for a given application.A wide variety of methods have been explored to synthesize MONs, either "top-down" by the exfoliation of layered metalorganic frameworks (MOFs) or "bottom-up" by assembly of molecular building blocks directly into nanosheets. The majority of top-down approaches utilize mechanical energy to overcome inter-layer interactions, such as liquid-assisted ultrasonication, [19] shear-mixing, [20] and grinding/ball-milling, [13] or the less common freeze-thaw [21] and "scotch-tape" methods. [22,23] Other methods involving photochemical, [24] electrochemical, [25] and chemical intercalation, [26] have also been developed but are less widely used. Bottom-up methodologies typically utilize surfactants or modulators to inhibit crystal growth in one dimension, [12,27,28] or layering/interfacial methods to promote anisotropic growth. [15,29,30] The use of sacrificial 2D templates has also recently emerged a promising route. [31,32] Each approach has advantages and disadvantages in terms of the thickness, lateral dimensions, size distribution, quantity and quality of the MONs produced, and the best approach therefore varies depending on the application.

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Section: Biological Moleculesmentioning

confidence: 99%

Metal–Organic Framework Nanosheets: Programmable 2D Materials for Catalysis, Sensing, Electronics, and Separation Applications

Nicks¹,

Sasitharan²,

Prasad³

et al. 2021

Adv Funct Materials

115

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“…MNPs have been employed as transducer surface modifiers to both enhance the capacity for the stable and well-oriented immobilization of biomolecules and improve the charge transport rates [ 6 ]. Taking advantage of these properties, a variety of electrode scaffolds using MNPs have been designed for the construction of enzyme biosensors [ 7 , 8 , 9 , 10 ], immunosensors [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], aptasensors [ 26 , 27 , 28 , 29 , 30 , 31 ], and DNA biosensors [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Table 1 summarizes the main characteristic, including the nanomaterial roles, the limits of detection, and the analyzed sample, of the electrochemical biosensing strategies involving multifunctional MNPs.…”

Section: Multifunctional Metal-based Nanomaterialsmentioning

confidence: 99%

“…Furthermore, the electrochemical immunosensor was fabricated by capture antibody assembling onto a GCE modified with AuNPs-functionalized carbon nanotubes (Au@MWCNTs/GCE). The immunosensor allowed greatly amplified amperometric responses over a wide linear range of 200 fg mL −1 to 50 ng mL −1 [ 12 ].…”

Section: Multifunctional Metal-based Nanomaterialsmentioning

confidence: 99%

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Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

et al. 2020

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Multifunctional nanomaterials, defined as those able to achieve a combined effect or more than one function through their multiple functionalization or combination with other materials, are gaining increasing attention in the last years in many relevant fields, including cargo targeted delivery, tissue engineering, in vitro and/or in vivo diseases imaging and therapy, as well as in the development of electrochemical (bio)sensors and (bio)sensing strategies with improved performance. This review article aims to provide an updated overview of the important advances and future opportunities exhibited by electrochemical biosensing in connection to multifunctional nanomaterials. Accordingly, representative aspects of recent approaches involving metal, carbon, and silica-based multifunctional nanomaterials are selected and critically discussed, as they are the most widely used multifunctional nanomaterials imparting unique capabilities in (bio)electroanalysis. A brief overview of the main remaining challenges and future perspectives in the field is also provided.

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“…These attractive features, once combined with good biocompatibility and biodegradability, 1 following a careful choice of the metal and organic linkers, are suitable to meet the practical demands for several potential applications such as gas separation, 5-7 transport 8 and storage, 9,10 catalysis, [11][12][13] sensing, 14 energy, 15,16 and bioapplications.…”

Section: Introduction Of Mofsmentioning

confidence: 99%

Metal–organic frameworks towards bio-medical applications

Lepoitevin

Serre

2021

Mater. Chem. Front.

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An enzyme-free ultrasensitive electrochemical immunosensor for calprotectin detection based on PtNi nanoparticles functionalized 2D Cu-metal organic framework nanosheets

Cited by 52 publications

References 25 publications

Metal–Organic Framework Nanosheets: Programmable 2D Materials for Catalysis, Sensing, Electronics, and Separation Applications

Metal–Organic Framework Nanosheets: Programmable 2D Materials for Catalysis, Sensing, Electronics, and Separation Applications

Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

Metal–organic frameworks towards bio-medical applications

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