Lung cancer prediction is crucial for early detec-tion and treatment, and explainable AI models have gained attention for their interpretability. This study aims to compare various explainable AI models using diverse datasets for lung cancer prediction. Clinical, genomic, and imaging data from multiple sources were collected, prepro-cessed, and used to train models such as Logistic Regression, SVC-Linear, SVC-rbf, Decision Tree, Random Forest, AdaBoost Classifier, and XGBoost Classifier. Preliminary results indicate that Random Forest achieved the highest accuracy of 98.9% across multiple datasets. Evaluation metrics such as accuracy, precision, recall, and F1 score were utilized, along with interpretability techniques like feature importance rankings and rule extraction methods. The study's findings will aid in identifying effective and interpretable AI models, facilitating early detection and treatment decisions for lung cancer.