The purpose is to improve the power and innovate the communication mode of mainstream I&P (Ideological and Political) education in C&U (Colleges and Universities). The opportunities and challenges that I&P education is facing or will face in media times are analyzed from three factors: the subjective, the mediator, and the environment, which affect the power of mainstream I&P in C&U. Educational means, carriers, resources, places and times, and the interactions between educators and the educated can bring opportunities for the improvement of the educational power of C&U. However, there are great challenges in all aspects of the mainstream ideology, such as education methods, education ideas, education content, education leadership and discourse power, and network public opinion control. Finally, a series of measures are proposed to improve the power of mainstream I&P education in C&U in media times, and they are updating the concept of media education, strengthening the ideological guidance, ensuring the direction of mainstream I&P education, and optimizing the media environment so that a more perfect innovative mode of I&P education is constructed. The research enriches and develops the theory of mainstream I&P education in C&U, innovates the methods of mainstream I&P education in C&U, and enhances the power of mainstream I&P education.