Semi-leptonic B decays provide promising channels to test the Standard Model, search for signs of new physics, or determine fundamental parameters like CKM matrix elements. We present an update on our calculation of short distance contributions to GIM suppressed rare B decays focusing in particular on B s → φ + − decays. Furthermore we show first results for our calculation ofν semi-leptonic decays involving b → c transitions. Our calculations are based on RBC-UKQCD's 2+1 flavor domain-wall fermion and Iwasaki gauge field configurations featuring three lattice spacings in the range 1.73 GeV ≤ a −1 ≤ 2.77 GeV and pion masses down to the physical value. We calculate the form factors by simulating b-quarks using the relativistic heavy quark action, create light u/d and s quarks with standard domain-wall kernel, and use optimised Möbius domain-wall fermions for charm quarks.