An Exploratory Study of Postpartum Depression and Vitamin D

Murphy, Pamela K.; Mueller, Martina; Hulsey, Thomas C.; Ebeling, Myla; Wagner, Carol L.

doi:10.1177/1078390310370476

Cited by 73 publications

(78 citation statements)

References 23 publications

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“…The prevalence of vitamin D deficiency (82.6%) in our study was in the range of a recent study done in a sample of pregnant women at the Medical University of South Carolina in Charleston, SC, USA, which reported that 82% of women had insufficiency and/or deficiency. 24 The mean 25[OH]D levels in pregnant African-American, Hispanic and White women were 15.5 AE 7.2, 24.1 AE 8.7 and 29.0 AE 8.5 ng/ml, respectively. 31 The median serum level of 25[OH]D in our sample was 13.8 (IQR 9.4-17.1) ng/ml.…”

Section: Resultsmentioning

confidence: 92%

“…21,22 Recent findings from a randomised trial suggested that high doses of supplemental vitamin D may improve mild symptoms of depression. 23 In addition, several studies have found that mood disorders are significantly associated with low levels of serum 25[OH]D, a reliable measurement of vitamin D. 24 There is little research in the literature exploring the implications of decreased levels of 25[OH]D on the prevalence of PPD. Therefore, the purpose of the present study was to assess a possible relationship between vitamin D status and PPD using the serum level of 25[OH]D collected 24-48 hours after delivery in a Chinese cohort sample.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum 25‐hydroxyvitamin D levels measured 24 hours after delivery and postpartum depression

et al. 2014

BJOG

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Objective To assess the possible relationship between serum levels of 25[OH]D (25-hydroxyvitamin D) collected 24 hours after delivery and postpartum depression in a Chinese cohort sample.Design Cohort study.Setting One city hospital in Beijing, China.Population Women delivering a full-term, singleton, live-born infant at one city hospital in Beijing between August 2013 and November 2013.Methods Women were enrolled immediately postpartum. A blood sample was obtained 24-48 hours after childbirth to test serum levels of 25[OH]D. Participation consisted of a visit to an obstetric unit 3 months after delivery.Main outcome measure At 3 months' postpartum, women were screened for depression using the Edinburgh Postnatal Depression Scale (EPDS). The primary outcome measure was a prespecified EPDS score of ≥12.Results During the study period, 323 women were admitted. In all, 248 agreed to enrol and 213 completed 3 months' follow-up (21 were lost to follow-up and 14 withdrew). Of the 213 women who were included, 26 (12.2%) were considered to meet criteria for postpartum depression. Serum 25[OH]D levels in women with no postpartum depression were significantly higher than those in women with postpartum depression (P < 0.0001). Based on the receiver operating characteristic curve, the optimal cutoff value for serum 25[OH]D level as an indicator for screening for postpartum depression was estimated to be 10.2 ng/ml, with an area under the curve of 0.801 (95%CI 0.704-0.896). In multivariate analysis, there was an increased risk of postpartum depression associated with 25[OH]D levels ≤10.2 ng/ml (OR 7.17,; P < 0.0001) after adjusting for possible confounders.Conclusion Our study demonstrated that lower serum 25[OH]D levels were associated with postpartum depression. This association was independent of other possible variables.

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Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Association between serum 25‐hydroxyvitamin D levels measured 24 hours after delivery and postpartum depression

et al. 2014

BJOG

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“…In addition, researchers explored the relationship between low vitamin D and pregnancy-related depression. Murphy et al showed a link between maternal low serum concentrations of 25-hydroxyvitamin D and elevated depression scores after birth (16). In a study by Brandenburg et al, a reverse link was found between 25-hydroxyvitamin D concentration and maternal depression score at 16 weeks of gestation (17).…”

Section: Introductionmentioning

confidence: 90%

Vitamin D Level, Thyroid Function, and Maternal Depression in Late Pregnancy

et al. 2018

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Background: Based on a possible association between thyroid function or serum 25-hydroxyvitamin D concentration and perinatal psychological symptoms, this study examined the potential link between antenatal depression and thyroid function or vitamin D level in the population of Shiraz city. Methods: This cross-sectional study was conducted on mothers, who were under prenatal care at a teaching hospital in Shiraz, during year 2015. Evaluation of depression was performed by the Edinburgh postnatal depression scale (EPDS). Eligible pregnant

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“…In a study done to shed a light on the effect of vitamin D deficiency on the occurrence of PPD, a significant correlation between low levels of 25-OH D3 over time, which is a sign of postpartum depression, and high EPDS scores was discovered. 24 Postpartum depression was most often seen in winter months. 27,28 In a study, Fu et al have found serum 25-OH D3 levels in women without PPD higher that in women suffering from postpartum depression.…”

Section: Omega-3 Fatty Acidmentioning

confidence: 99%

“…23 Vitamin D deficiency (25-OH D3 <32 ng/mL) is an epidemic affecting 75% of women of childbearing age. 24 Maternal vitamin D deficiency is common during pregnancy and even with vitamin D supplements vitamin D is sufficient in only a small percentage of women and babies. 25 Low levels of vitamin D can be overlooked as a risk factor for PPD.…”

Section: Omega-3 Fatty Acidmentioning

confidence: 99%

Correlation between postpartum depression and omega-3, micronutrients

Mermer

Şanlıer

2017

Int J Reprod Contracept Obstet Gynecol

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In recent years, attention has been called to the link between nutrition and mental health. Postpartum depression is an important depressive disorder which often arises 6 to 12 weeks after giving birth and can happen at any time within one year. Postpartum depression prevalence is around 20% worldwide. Genetic predisposition and environmental factors, as well as certain social, psychological and biological factors constitute risk factors for postpartum depression. While malnutrition is among the biological factors, there is a correlation between nutrients such as folic acid, vitamin B₁₂, vitamin D, iron, selenium, zinc, and n-3 fatty acids and psychological state. The nutrients that claim most attention relating to postpartum depression are n-3 essential fatty acids. Insufficient intake of n-3, folic acid, vitamins B and iron is observed in pregnant women. Failing to meet the needs of the mother due to malnutrition during pregnancy can increase the risk of depleting the body’s nutrient reserves and developing postpartum. This risk factor needs to be kept in check by determining and keeping track of the nutrient needs of the mother during the perinatal period.

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An Exploratory Study of Postpartum Depression and Vitamin D

Abstract: Future rigorous studies investigating vitamin D and postpartum depression are warranted with larger sample sizes using confirmatory methods to diagnose postpartum depression.

Cited by 73 publications

References 23 publications

Association between serum 25‐hydroxyvitamin D levels measured 24 hours after delivery and postpartum depression

Association between serum 25‐hydroxyvitamin D levels measured 24 hours after delivery and postpartum depression

Vitamin D Level, Thyroid Function, and Maternal Depression in Late Pregnancy

Correlation between postpartum depression and omega-3, micronutrients

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