An extended duration operation for solid hollow fiber membrane-based cooling crystallization

Jin, Chi; Chen, Dengyue; Sirkar, Kamalesh K.; Pfeffer, Robert

doi:10.1016/j.powtec.2019.04.010

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…A similar situation arose in another crystallization technique based on cooling crystallization, namely, solid hollow fiber cooling crystallization (SHFCC) technique , which used solid hollow fiber membranes of polypropylene. Since the experiments there were carried out for only 5–10 min, a separate study was recently completed, where the continuous operation was demonstrated for 60–120 min.…”

Section: Introductionmentioning

confidence: 99%

An Extended Duration Operation for Porous Hollow Fiber-Based Antisolvent Crystallization

Wang

Liu

et al. 2019

Ind. Eng. Chem. Res.

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Poor aqueous solubility of numerous active pharmaceutical ingredients has raised considerable concern about the bioavailability of drugs. A porous hollow fiber antisolvent crystallization (PHFAC) device was designed to continuously produce drug nanocrystals under ambient conditions. The drug solution pumped into the shell side of the module encountered jets of antisolvent deionized water from tiny pores on the hollow fiber walls inducing a high degree of supersaturation as well as crystallization of the obtained nanoparticles. To study the effect of duration of operation for the PHFAC module and the stability of the nanocrystal production, a larger-scale and a smaller-scale module were designed to compare the nanocrystals in a 60 min long experiment. The characterized results showed that the nanocrystals were stable in size and morphology, and the nanocrystals produced by the larger-scale module presented no difference from those of the small-scale module. Meanwhile, the drug nanoparticles remained unchanged for the 28 days during repeated production, indicating excellent stability. It appears possible that the experiment could be scaled up to bring the application to industrial practice.

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Section: Introductionmentioning

confidence: 99%