An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen

Boscá, Ana Ramírez; Soler, A.; Carrión-Gutiérrez, Miguel A; Mira, D. Pamies; Zapata, José Pardo; Diaz-Alperi, Joaquı́n; Bernd, August; Almagro, Eliseo Quintanilla; Miquel, Jaime

doi:10.1016/s0047-6374(00)00089-0

Cited by 56 publications

(21 citation statements)

References 10 publications

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“…The authors reported a marked decrease in the level of serum lipid peroxides (33%), an increase in HDL cholesterol (29%), and a decrease in total serum cholesterol (11.63%) following curcumin supplementation, suggesting the chemopreventive role of this compound for treating arterial diseases [192]. Analogous observations were made in another study in which curcumin lowered LDL and increased HDL in atherosclerosis patients [193]. Rasyid et al [194] showed the protective effects of 20 mg of curcumin in improving gallbladder function and reducing gallstone formation.…”

Section: Studies Of Curcumin In Human Subjectsmentioning

confidence: 79%

Multi‐targeted therapy by curcumin: how spicy is it?

Goel

Jhurani

Aggarwal³

2008

Molecular Nutrition Food Res

212

134

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Although traditional medicines have been used for thousands of years, for most such medicines neither the active component nor their molecular targets have been very well identified. Curcumin, a yellow component of turmeric or curry powder, however, is an exception. Although inhibitors of cyclooxygenase-2, HER2, tumor necrosis factor, EGFR, Bcr-abl, proteosome, and vascular endothelial cell growth factor have been approved for human use by the United States Food and Drug Administration (FDA), curcumin as a single agent can down-regulate all these targets. Curcumin can also activate apoptosis, down-regulate cell survival gene products, and up-regulate p53, p21, and p27. Although curcumin is poorly absorbed after ingestion, multiple studies have suggested that even low levels of physiologically achievable concentrations of curcumin may be sufficient for its chemopreventive and chemotherapeutic activity. Thus, curcumin regulates multiple targets (multitargeted therapy), which is needed for treatment of most diseases, and it is inexpensive and has been found to be safe in human clinical trials. The present article reviews the key molecular mechanisms of curcumin action and compares this to some of the single-targeted therapies currently available for human cancer.

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Section: Studies Of Curcumin In Human Subjectsmentioning

confidence: 79%

Multi‐targeted therapy by curcumin: how spicy is it?

Goel

Jhurani

Aggarwal³

2008

Molecular Nutrition Food Res

212

134

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“…In a pre-post study, Ramı´rez-Bosca´ reported that oral administration of 10 mg curcumin extract per day for 30 days to 8 human subjects elevated HDL-C and apo A as well as lowered LDL-C, apo B and apo B/apo A ratio [158]. The same research team also found that 10 mg curcumin (twice/day) for 15 days significantly suppressed the levels of plasma fibrinogen in study subjects, which may reduce the risk for coronary disease [159]. In a randomized, double-blinded, placebo-controlled trial, Baum et al [160] investigated the effects of curcumin consumption on the serum lipid profile in elderly men and women.…”

Section: Curcuminmentioning

confidence: 99%

Novel insights of dietary polyphenols and obesity

Wang

Moustaid‐Moussa

Chen

et al. 2014

The Journal of Nutritional Biochemistry

774

575

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Prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here we evaluated the impact of commonly consumed polyphenols, including green tea catechins and epigallocatechin gallates, resveratrol, and curcumin, on obesity and obesity-related-inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the AMP-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, PPAR gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor kappa B that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass, and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area, and are inconsistent about the anti-obesity impact of dietary polyphenols, probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.

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“…One of the first studies showed that curcumin lowered blood sugar levels in diabetic patients (178). Another study examined the effect of curcumin in humans on the levels of HDL- and LDL-cholesterol (146). Administration of 10 mg curcumin per day for 30 days to eight human subjects increased HDL-cholesterol, decreased LDL-cholesterol, and increased APO A but decreased APO B and APO A/B.…”

Section: Human Studiesmentioning

confidence: 99%

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

2010

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Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-γ and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity. Other structurally homologous nutraceuticals, derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance.

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An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen

Cited by 56 publications

References 10 publications

Multi‐targeted therapy by curcumin: how spicy is it?

Multi‐targeted therapy by curcumin: how spicy is it?

Novel insights of dietary polyphenols and obesity

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

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