An<i>in vitro</i>and<i>in vivo</i>investigation into the suitability of compression coated tablets of indomethacin for the treatment of rheumatoid arthritis which follow circadian rhythms

Songa, Ambedkar Sunil; Meka, Venkata Srikanth; Nali, Sreenivasa Rao; Kolapalli, Venkata Ramana Murthy

doi:10.3109/03639045.2012.662509

Cited by 10 publications

(3 citation statements)

References 24 publications

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“…The foremost technical inconvenience faced in the line of the pharma industry is altering the drug delivery patterns as per the therapy requisite (Li et al., 2008 ). This approach can improve treatment effectiveness, minimize adverse effects, and enhance patient adherence (Songa et al., 2013 ; Sunil et al., 2013 ). This technique of modifying drug kinetics and release patterns have beneficial value, particularly in managing several chronic diseases like rheumatoid arthritis that exhibit early morning pathologies.…”

Section: Introductionmentioning

confidence: 99%

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Aldawsari

Naveen²,

Alhakamy

et al. 2022

Drug Delivery

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Pulsatile drug delivery systems have drawn attention in contemporary research for designing chronotherapeutic systems. The current work aims to design pulsatile ketorolac tromethamine tablets using compression coating for delayed delivery with a lag time suitable for the treatment of morning stiffness in arthritis. Rapidly disintegrating core tablets of ketorolac tromethamine were formulated using super-disintegrants, and the optimized formulation was compression using PEO WSR coagulant and Eudragit RLPO for delaying the release. The central composite design and response surface methodology were employed to optimize the formulation and process parameters namely PEO WSR Coagulant (X 1 ), Eudragit RLPO (X 2 ), and Hardness (X 3 ). The dependent variables optimized were lag time and time required for 95% drug release. Analysis using response surface graphs and mathematical modeling of the results allowed identifying and quantifying the formulation variables active on the selected responses. A polynomial equation fitted to the data was used to predict the composition with optimum responses. Compression-coated pulsatile tablets’ optimized composition exhibited a lag time of 9 h and released 95% of the ketorolac tromethamine in 17.42 h. Validation of the mathematical model assured the reliability of QBD in formulation design. In vivo X-ray imaging and pharmacokinetic studies established a strong relationship between the coated polymers maintaining the desired lag time for delayed delivery of the active to coincide with the chronobiology for enhanced bioavailability at the right time when needed.

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Section: Introductionmentioning

confidence: 99%

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Aldawsari

Naveen²,

Alhakamy

et al. 2022

Drug Delivery

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show abstract

“…(2017) Investigating critical effects of variegated lubricants, glidants and hydrophilic additives on lag time of press coated ethylcellulose tablets Compression coating Tablets EC Prednisone Patadia et al (2015a) Formulation and evaluation of multiparticulate system for chronotherapeutic delivery of salbutamol sulfate Pan coating Pellets Eudragit RSPO, Eudragit L100 Salbutamol sulfate Chaudhari and Chaudhari, 2012 Investigating effects of hydroxypropyl methylcellulose (HPMC) molecular weight grades on lag time of press-coated ethylcellulose tablets Compression coating Tablets EC, HPMC Prednisone Patadia et al. (2015) An in vitro and in vivo investigation into the suitability of compression coated tablets of indomethacin for the treatment of rheumatoid arthritis which follow circadian rhythms Compression coating Tablets PEO WSR Coagulant Indomethacin Songa et al. (2013) Formulation development and statistical optimization of chronotherapeutic tablets of indometacin Compression coating Tablets HPMC Indomethacin Tinny et al.…”

Section: Application Of Coating To Chronotherapeuticsmentioning

confidence: 99%

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Gowthami

Krishna

Rao

2021

Current Research in Pharmacology and Drug Discovery

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In general, extended release systems have the ability to maintain the drug concentration with in therapeutic range for prolonged period of time, but this may not be the primary requisite for circadian rhythm diseases like asthma, hypertension and rheumatoid arthritis, etc. They require prompt release of drug as per the disease condition, which can be achieved by programmed lag time. Chronotherapeutic drug delivery systems (CDDS) can be achieved by several methods, coating is one amongst them. Though the coating process is complex in terms of methodology, solubility issues and difficulty in achieving the uniform coating, many researchers were successfully employed in development of CDDS. A scientific prospection was made from 2010 to 2020 using PubMed database. Apart from exploration of publication data, we attempt to brief about classification of patents and concordance. The scrutiny also highlights the patents filed on chronotherapeutic systems, focusing particularly on coating technologies. The review is concluded the successful application of coating technology to develop CDDS, as evident from vast number of publications and patents filed.

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“…Although less frequently, the use of PEO has also been reported [52][53][54]. Coating formulations based on polysaccharides of natural origin, mainly pectin [55][56][57], guar gum [58,59], xanthan gum [59] and locust bean gum [60] have extensively been employed especially due to their biodegradability by colonic bacteria.…”

Section: Press Coatingmentioning

confidence: 99%

Dry coating of solid dosage forms: an overview of processes and applications

Foppoli

Cerea

Zema

et al. 2017

Drug Development and Industrial Pharmacy

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Dry coating techniques enable manufacturing of coated solid dosage forms with no, or very limited, use of solvents. As a result, major drawbacks associated with both organic solvents and aqueous coating systems can be overcome, such as toxicological, environmental, and safety-related issues on the one hand as well as costly drying phases and impaired product stability on the other. The considerable advantages related to solventless coating has been prompting a strong research interest in this field of pharmaceutics. In the article, processes and applications relevant to techniques intended for dry coating are analyzed and reviewed. Based on the physical state of the coat-forming agents, liquid- and solid-based techniques are distinguished. The former include hot-melt coating and coating by photocuring, while the latter encompass press coating and powder coating. Moreover, solventless techniques, such as injection molding and three-dimensional printing by fused deposition modeling, which are not purposely conceived for coating, are also discussed in that they would open new perspectives in the manufacturing of coated-like dosage forms.

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Anin vitroandin vivoinvestigation into the suitability of compression coated tablets of indomethacin for the treatment of rheumatoid arthritis which follow circadian rhythms

Abstract: Unaltered AUC(0-t) and C(max), but delayed T(max) indicated clear lag time before immediate release of drug which is suitable for treating rheumatoid arthritis following circadian rhythm.

Cited by 10 publications

References 24 publications

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Dry coating of solid dosage forms: an overview of processes and applications

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