An imine-linked covalent organic framework for renewable and sensitive determination of antibiotic

Imine-Linked Covalent Organic Framework Modulates Oxidative Stress in Alzheimer’s Disease

“…The 0.5 mM Cu 2 + solution was incubated with SC@COF-T5, and Figure C reveals that the concentration of Cu 2+ in the supernatant decreased with the concentration of SC@COF-T5 increasing from 0 to 250 μg/mL, indicating that SC@COF-T5 can chelate with Cu 2 + within the range of physiological concentrations. The good Cu 2+ chelating capability of SC@COF-T5 is most likely due to the incorporation of an imine ligand and metal ions. ,, To prove that the imine-based structure of the COF is beneficial to the binding of Cu 2+ , some theoretical calculations were conducted. It can be seen from Figure S10 that Cu 2+ can combine with the N atom on the imine group in the COF, and the Gaussian calculated binding energy of Cu 2+ to the unit structure of the COF is −6792 kJ/mol.…”

“…For in vivo applications, carriers are always needed to protect and transport SOD and CAT to specific locations , because of their instability and nonspecific distribution. Among various kinds of nanomaterials, covalent organic frameworks (COFs), as a kind of crystalline porous networks connected by covalent bonds, − have the advantages of desirable biocompatibility, good biodegradability, and easier surface decoration, making them an excellent carrier for biomedical application. − Furthermore, COFs with imine structures can serve as host materials to coordinate metallic guests due to the strong coordination between electronegative N atoms with metal ions. − Metal ion-loaded imine COFs have been widely applied in catalysis and sensing. , Based on the above analysis, the imine COFs loaded with SOD and CAT may be suitable to acquire the anticipation of eradicating the oxidative stress of the AD brain by their robust ROS scavenging and Cu 2+ chelating ability.…”

The postsynthetic renaissance of luminescent lanthanide ions on crystalline porous organic framework materials

“…110 Ren et al adopted the Pda ( P -phenylenediamine) and Dfp (2,6-diformylpyridine) ligands in mesitylene and 1,4-dioxaneto solution to construct a PdaDfp COF, and afterwards, Tb 3+ ions were anchored onto the PdaDfp COF through stirring PdaDfp and Tb(NO 3 ) 3 ·6H 2 O in acetonitrile solution. 111 Wang et al synthesized a TpPa-1 COF via adding a Tp ligand into a mixture of Pa-1 and p -toluenesulfonic acid and then heating the mixture. Subsequently, the TpPa-1 COF was added into an EuCl 3 ·6H 2 O solution to fabricate an Eu 3+ @TpPa-1 material, which was used for the fluorescence detection of levofloxacin.…”

Magnetic Resonance Diagnosis of Early Triple-Negative Breast Cancer Based on the Ionic Covalent Organic Framework with High Relaxivity and Long Retention Time

“…The superior r 1 of Mn-iCOF can be attributed to the slower tumbling rates of CA and longer residence lifetime of Mn-centered coordinated water molecules. This is due to the good water solubility and porous structure of iCOF. , The Mn-iCOF facilitates a higher signal-to-noise ratio than that of the commercial Gd-based CA in 4T1 tumor-bearing mice. Interestingly, the Mn-iCOF is also effective for improving MR imaging in ultrasmall LNs (approximately 3 mm) with a retention time of at least 24 h. It is expected that Mn-iCOF based MRI can contribute to the early diagnosis of TNBC and provide enough information to accurately dissect LNs.…”