1989
DOI: 10.1111/j.1440-1827.1989.tb01496.x
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An Immunohistochemical Study of Cytokeratin and Vimentin in Benign and Malignant Thyroid Lesions

Abstract: Intermediate filaments in benign and malignant thyroid lesions were immunohistochemically studied using polyclonal and monoclonal anti‐cytokeratin (CK), and monoclonal anti‐vimentin antibodies. Antigenicity of CK and vimentin was almost completely destroyed during formalin fixation in normal thyroid and all thyroid lesions except for some cases of papillary and squamous cell carcinoma, although the latter showed negative immunostaining with anti‐vimentin antibody. In sections fixed with Carnoy's fixative, most… Show more

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Cited by 13 publications
(11 citation statements)
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“…Confirming previous reports on the CK pattern of the normal thyroid gland [3,6,11,16,23,24,27,28,31], we observed the constant and high expression of simple epithelial-type CKs 7 and 18 and, to a lesser degree, of CKs 8 and 19. There was absence of expression of keratins characteristic of stratified epithelia, such as CKs 1, 4, 5/6 and 13, and also CK 20, in normal thyroid tissues.…”
Section: Discussionsupporting
confidence: 91%
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“…Confirming previous reports on the CK pattern of the normal thyroid gland [3,6,11,16,23,24,27,28,31], we observed the constant and high expression of simple epithelial-type CKs 7 and 18 and, to a lesser degree, of CKs 8 and 19. There was absence of expression of keratins characteristic of stratified epithelia, such as CKs 1, 4, 5/6 and 13, and also CK 20, in normal thyroid tissues.…”
Section: Discussionsupporting
confidence: 91%
“…Our finding of CK 19 expression in all cases of FC we have studied argues against such a statement, although we have confirmed the preferential and usually stronger expression of CK 19 in PCs than in FCs. The PCs in our series expressed simple epithelial-type CKs 7, 8, 18 and 19, with a particularly impressive presence of CK 19, confirming previous observations [6,23,27,31]. Moreover, we were able to demonstrate the presence of high molecular weight CKs 5/6 and 13 in most of the cases of PC.…”
Section: Discussionsupporting
confidence: 90%
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“…1 On histologic sections, cytokeratin 19 has been expressed in all tumor cells of thyroid papillary carcinomas, but it has been absent or only focally present in follicular neoplasms and adenomatous goiters. [2][3][4][5] However, on cytologic smears there have been no reports concerning the expression of cytokeratin 19. Therefore, we investigated whether immunocytochemical staining using the anticytokeratin 19 antibody in cytologic smears is helpful in distinguishing among papillary carcinoma, adenomatous goiter, and follicular neoplasms of the thyroid.…”
Section: Dear Dr Bedrossianmentioning
confidence: 99%
“…nigne und maligne Schilddrü sentumoren anhand von Gefrierschnitten sowie Paraffinschnitten Formalinund Carnoy-fixierten Materials auf Reaktivitä t mit Antikö rpern gegen Pan-CK, CK 7, CK 8 und CK 19 geprü ft[33]. Bemerkenswert ist dabei die bereits an fixierten Proben höhere Rate CK 7-positiver papillä rer Karzinome als nichtpapillä rer Schilddrü sentumoren.…”
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