2019
DOI: 10.3892/ol.2019.11172
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An improved mouse orthotopic bladder cancer model exhibiting progression and treatment response characteristics of human recurrent bladder cancer

Abstract: Nonmuscle-invasive (superficial) bladder cancer is generally treated via surgical removal, followed by adjuvant therapy (bacillus Calmette-Guerin). However, bladder cancer can often recur, and in a substantial number of recurrent cases, the cancer progresses and metastasizes. Furthermore, residual microtumors following excision may lead to an increased risk of recurrence. An in vivo model mimicking the pattern of urinary bladder microtumor regrowth may provide an effective experimental system for improving pos… Show more

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Cited by 4 publications
(3 citation statements)
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“…Compared to a subcutaneous transplant xenograft model, the orthotopic tumor implantation mimics the natural environment of bladder cancer, with intact pathological and immunological responses [ 18 , 19 ]. Most of the current methods for nucleic acid therapies are unsuitable for clinical use owing to their low uptake efficiency and high cytotoxicity [ 20 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Compared to a subcutaneous transplant xenograft model, the orthotopic tumor implantation mimics the natural environment of bladder cancer, with intact pathological and immunological responses [ 18 , 19 ]. Most of the current methods for nucleic acid therapies are unsuitable for clinical use owing to their low uptake efficiency and high cytotoxicity [ 20 ].…”
Section: Discussionmentioning
confidence: 99%
“…An orthotopic animal model was established using a previously described technique [ 19 ]. Briefly, female mice were anesthetized with 1–2% isoflurane (Pfizer, New York, NY, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Recently, Naito et al reported a cell-injection orthotopic model of UM-UC-3 bladder cancer (25). Huebner et al have developed a luciferase-expressing cell-injection orthotopic model of UM-UC-3 bladder cancer (26).…”
mentioning
confidence: 99%