An in-vitro study of antimicrobial activity of homoeopathic medicine pyrogenium against Escherichia coli

Abstract

The discovery of new drugs with antimicrobial activity against E. coli is crucial for public health and the fight against other antibiotic-resistant bacteria with the MCR-1 gene detected in China and a polymyxin B-resistant strain in Brazil. Novel approaches to drug discovery and alternative medicine like Homoeopathy possess immense potential in this regard. Studies have proved significant antimicrobial action in mineral and plant based Homoeopathic medicines. Homoeopathic nosode Pyrogenium known as 'dynamic antiseptic' with homoeopathic literature to support might have antimicrobial potential in higher potencies. Antimicrobial activity of Pyrogenium 30C and 200C against Escherichia coli O157:H7 is tested using the Kirby-Bauer method with Müeller-Hinton Agar (MHA) as the medium. The zone of inhibition and relative growth inhibition percentage is analysed. Pyrogen 200 C showed a negligible zone of inhibition with negligible relative growth inhibition while Pyrogenium 30 C showed mild to moderate zone of inhibition with relative growth inhibition of 7.14%.

Medicinal values of the genus Phyllanthus - A review

“…This plant has a natural antioxidant, antimicrobial, and immunomodulator, which will increase the immune system's components and improve the immune system's function (Hidanah et al, 2018). Bioactive compounds have antimicrobial (Adeolu and Sunday, 2013;Unigwe et al, 2021), anti-inflammatory (Dada et al, 2014;Unigwe et al, 2020), anti-diabetic (Evi and Degbeku, 2011), antioxidant (Lim and Murtijaya, 2007), anticonvulsant activity (Manikkoth et al, 2011), anti-diarrhoeal (Unigwe et al, 2021, anti-carcinogenic and anticancer (Rajeshkumar et al, 2002) as well as antiviral (Salazar et al, 2011;Prasad et al, 2013).…”