Antibiotic resistance in E. coli is a global health concern, with the MCR-1 gene detected in China and a polymyxin B-resistant strain in Brazil. Novel drug discovery approaches and alternative therapies like homoeopathy can help especially using nosodes. Even though Psorinum is a powerful Homoeopathic nosode, it has little to no studies on its antimicrobial activity. Antimicrobial activity of Psorinum 30C and 200C against Escherichia coli O157:H7 is tested using the Kirby-Bauer method with Müeller-Hinton Agar (MHA) as the medium. The zone of inhibition and relative growth inhibition percentage is analysed. Psorinum 200 C showed significant zone of inhibition with relative growth inhibition of 28.57% while Psorinum 30 C showed mild to moderate zone of inhibition with relative growth inhibition of 7.14%.

The discovery of new drugs with antimicrobial activity against E. coli is crucial for public health and the fight against other antibiotic-resistant bacteria with the MCR-1 gene detected in China and a polymyxin B-resistant strain in Brazil. Novel approaches to drug discovery and alternative medicine like Homoeopathy possess immense potential in this regard. Studies have proved significant antimicrobial action in mineral and plant based Homoeopathic medicines. Homoeopathic nosode Pyrogenium known as 'dynamic antiseptic' with homoeopathic literature to support might have antimicrobial potential in higher potencies. Antimicrobial activity of Pyrogenium 30C and 200C against Escherichia coli O157:H7 is tested using the Kirby-Bauer method with Müeller-Hinton Agar (MHA) as the medium. The zone of inhibition and relative growth inhibition percentage is analysed. Pyrogen 200 C showed a negligible zone of inhibition with negligible relative growth inhibition while Pyrogenium 30 C showed mild to moderate zone of inhibition with relative growth inhibition of 7.14%.

A sample of 15 cases of post-menopausal diabetic women from OPD of Sarada Krishna Homoeopathic Medical College and Hospital were selected, detailed case taking was done and Helonias Dioica in different potencies was administered as per the directions of 5th and 6th editions of Organon of medicine, including its repetition and dosage. FBS and serum HbA1c levels of the individual were measured on the first visit itself. Advices were given to follow a healthy diet. The cases were followed up for 12 weeks to obtain correct changes in serum HbA1c. FBS was analysed in follow ups of every 2 weeks and the repetition of dose, change in potency/medicine was decided based on the overall condition of the patient. After 3 months, HbA1c level was taken and in about 80% of the cases had their HbA1c levels reduced.