An increase in inflammation and islet dysfunction is a feature of prediabetes

Weaver, Jessica L.; Odanga, Justin J.; Breathwaite, Erick; Treadwell, Michelle; Murchinson, Angela C; Walters, Gary; Fuentes, Danette P; Lee, Jung Bok

doi:10.1002/dmrr.3405

Cited by 23 publications

(15 citation statements)

References 42 publications

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“…Previous studies have reported increased levels of TNFα in serum samples of individuals with pre-DM [ 34 ]. Additionally, IL-1β is a macrophage-induced immune system modulator that decreases βcell activity and insulin sensitivity [ 35 ]. Overall, these findings suggest that elevated levels of liver enzymes and inflammation lead to the progression of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Identification of Pre-Diabetic Biomarkers in the Progression of Diabetes Mellitus

et al. 2021

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Type 2 diabetes mellitus (T2DM) is a major global health issue. The development of T2DM is gradual and preceded by the pre-diabetes mellitus (pre-DM) stage, which often remains undiagnosed. This study aimed to identify novel pre-DM biomarkers in a high-fat diet (HFD)-induced pre-DM mouse model. Male C57BL/6J mice were fed either a chow diet or HFD for 12 weeks. Serum and liver samples were isolated in a time-dependent manner. Semi-quantitative assessment of secretory cytokines was performed by cytokine array analysis, and 13 cytokines were selected for further analysis based on the changes in expression levels in the pre-DM and T2DM stages. HFD-fed mice gained body weight and exhibited high serum lipid, liver enzyme, glucose, and insulin levels during the progression of pre-DM to T2DM. The mRNA expression of inflammatory and lipogenic genes was elevated in HFD-fed mice The mRNA expression of Fc receptor, IgG, low affinity Iib, lectin, galactose binding, soluble 1, vascular cell adhesion molecule 1, insulin-like growth factor binding protein 5, and growth arrest specific 6 was elevated in the pre-DM, which was confirmed by measuring protein levels. Our study identified novel pre-DM biomarkers that may help to delay or prevent the progression of T2DM.

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Section: Discussionmentioning

confidence: 99%

Identification of Pre-Diabetic Biomarkers in the Progression of Diabetes Mellitus

et al. 2021

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“…However, it may be difficult to capture the overall effects of diet on health by studying the relationship of single nutrient with diseases. In this context, the dietary inflammatory index (DII) has been proposed to evaluate the inflammatory potential of the overall diet and link diet to inflammation which was a key driver in the progression of prediabetes and IR ( 12 , 13 ). The DII score is obtained from the diet of an individual based on the pro- and anti-inflammatory properties of the overall dietary compositions, namely, macronutrients, micronutrients, and some other dietary constituents.…”

Section: Introductionmentioning

confidence: 99%

Associations of Dietary Inflammatory Index With Prediabetes and Insulin Resistance

Shu

Wang

et al. 2022

Front. Endocrinol.

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Background and AimsPrevious studies suggested that dietary inflammatory index (DII) was associated with a variety of adverse health conditions. However, less is known about the role of DII in prediabetes and insulin resistance (IR). Therefore, this study aimed to investigate whether DII is associated with prediabetes and IR in American adults.Method and ResultsDII scores were calculated using the average of two 24-hour dietary recalls. Linear regression models were performed to evaluate the associations of DII with markers of Type 2 diabetes (T2D) risk, and the associations of DII with prediabetes and IR were estimated using logistic regression model. The diet of the participants showed an anti-inflammatory potential, with a mean DII score of −0.14 (range: −5.83 to +5.32). After controlling for multiple potential confounders, DII scores were positively associated with fasting plasma glucose (FPG) (β: 0.009; 95%CI: 0.005 to 0.012), fasting serum insulin (FSI) (β: 0.083; 95%CI: 0.067 to 0.099) and homeostatic model assessment of insulin resistance (HOMA-IR) (β: 0.092; 95%CI: 0.075 to 0.109). Participants in the highest tertile of DII score have increased odds of prediabetes (OR: 1.40; 95%CI: 1.17 to 1.69; P for trend <0.001) and IR (OR: 1.79; 95%CI: 1.49 to 2.14; P for trend <0.001) compared with those in the first tertile of DII score.ConclusionsThis study indicates that DII was positively associated with FPG, FSI, and HOMA-IR, and a more pro-inflammatory diet was related to increased odds of insulin resistant and prediabetes.

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“…Upadhyaya et al reported that serum IL-6 levels in impaired fasting glucose group was dramatically higher than normoglycemic group and mildly lower than hyperglycemic group [31] . It has been reported that IL-6 protein expression at sections of pancreas and isolated islets from prediabetes were signi cantly upregulated compared to the normal persons in a recent study, where the prediabetes criteria only included impaired fasting glucose and HbA1c [32] . Here we added indexes of FBG, 2hFBG and HbA1c into the prediabetes criteria to make the evidences more su cient.…”

Section: Discussionmentioning

confidence: 91%

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6 and TNF-α Levels in Prediabetes

Huang

Liang

et al. 2021

Preprint

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Background: The variation and correlation among adiponectin, nesfatin-1, TNF-α and IL-6, which involve in the process from healthy to prediabetes and diabetes have not been elucidated. This study aims to investigate the roles of them in this process. Methods: 72 T2DM, 75 prediabetes and 72 healthy individuals were enrolled and serum adiponectin, nesfatin-1, TNF-α and IL-6 were tested with appropriate kit, and primary data were analyzed with correct method. Results: serum levels of each factor in prediabetes were between T2DM and healthy, and significant differences were found among them. TNF-α and nesfatin-1 levels in T2DM obviously different compared to prediabetes or healthy; IL-6 and adiponectin levels in the healthy group were significantly changed in contrast to prediabetes or T2DM. Correlation analysis found that in prediabetes, adiponectin was positively correlated with TNF-α (R=0.2939, P=0.0105) and IL-6 (R=0.3918, P=0.0005), and the relationship greatly strengthened when prediabetes accompanied by insulin resistant (TNF-α: R=0.7732, P<0.0001, IL-6: R=0.6663, P=0.0005). We also demonstrated that declined adiponectin (OR=6.238, P=0.019), nesfatin-1 (OR=2.812, P=0.01) and elevated TNF-α (OR=5.541, P=0.001) were risk factors for prediabetes towards diabetes. Conclusions: this research proved significant variations of adiponectin, nesfatin-1, IL-6 and TNF-α levels in the healthy, prediabetes and T2DM, suggesting a slow and gradual change during the progression of healthy condition toward diabetes via prediabetes.

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An increase in inflammation and islet dysfunction is a feature of prediabetes

Cited by 23 publications

References 42 publications

Identification of Pre-Diabetic Biomarkers in the Progression of Diabetes Mellitus

Identification of Pre-Diabetic Biomarkers in the Progression of Diabetes Mellitus

Associations of Dietary Inflammatory Index With Prediabetes and Insulin Resistance

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6 and TNF-α Levels in Prediabetes

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