An Increase of Neuropeptide Y But Not Nitric Oxide Synthase-Immunoreactive Nerves in the Bladder Neck from Male Patients with Bladder Neck Dyssynergia

Crowe, R.; Noble, Jeremy; Robson, Tim; Soediono, P.; Milroy, E. J. G.; Burnstock, Geoffrey

doi:10.1016/s0022-5347(01)67037-x

Cited by 54 publications

(14 citation statements)

References 27 publications

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“…Neuropeptide Y. The human bladder is richly endowed with NPY-containing nerves (Gu et al, 1984;Iwasa, 1993;Crowe et al, 1995;Dixon et al, 1997). It seems that NPY can be found in adrenergic as well as cholinergic nerves.…”

Section: Peripheral Targetsmentioning

confidence: 99%

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Andersson

Wein²

2004

Pharmacol Rev

454

364

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Section: Peripheral Targetsmentioning

confidence: 99%

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Andersson

Wein²

2004

Pharmacol Rev

454

364

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“…Immunochemical characteristics of nerve fibers supplying the female rat urinary bladder may be affected for instance by: the chronic cystitis (Dickson et al 2006), the x-ray irradiation (Crowe et al 1996) or the treatment with biologically active substances like capsaicin or resiniferatoxin (RTX) (Avelino and Cruz 2000). The plastic changes of neurons were also observed in men with a form of the bladder neck obstruction, called bladder neck dyssynergia (Crowe et al 1995).…”

Section: H/npymentioning

confidence: 99%

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Lepiarczyk¹,

Bossowska²,

Kaleczyc³

et al. 2011

Polish Journal of Veterinary Sciences

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Botulinum toxin (BTX) belongs to a family of neurotoxins which strongly influence the function of autonomic neurons supplying the urinary bladder. Accordingly, BTX has been used as an effective drug in experimental therapies of a range of neurogenic bladder disorders. However, there is no detailed information dealing with the influence of BTX on the morphological and chemical properties of nerve fibres supplying the urinary bladder wall. Therefore, the present study investigated, using double-labeling immunohistochemistry, the distribution, relative frequency and chemical coding of cholinergic and noradrenergic nerve fibers supplying the wall of the urinary bladder in normal female pigs (n=6) and in the pigs (n=6) after intravesical BTX injections. In the pigs injected with BTX, the number of adrenergic (DβH-positive) nerve fibers distributed in the bladder wall (urothelium, submucosa and muscle coat) was distinctly higher while the number of cholinergic (VAChT-positive) nerve terminals was lower than that found in the control animals. Moreover, the injections of BTX resulted in some changes dealing with the chemical coding of the adrenergic nerve fibers. In contrast to the normal pigs, in BTX injected animals the number of DβH/NPY-or DβH/CGRP-positive axons was higher in the muscle coat, and some fibres distributed in the urothelium and submucosa expressed immunoreactivity to CGRP. The results obtained suggest that the therapeutic effects of BTX on the urinary bladder might be dependent on changes in the distribution and chemical coding of nerve fibers supplying this organ.

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“…Although in general BND patients, the urodynamic characteristics are similar to those that occurred in patients with DV or anatomical BOO, pure female BND suggesting obstruction mainly at bladder neck site. As a previous study reported, BND actually involves different types of dysfunctions, including LP‐BND and HP‐BND, resulting in an inhibitory effect and anatomically obstructive effect on micturition, respectively 20 . In patients with HP‐BND, the pathophysiology might be chronic inflammation of the bladder neck, resulting in an anatomical BOO and voiding difficulty.…”

Section: Discussionmentioning

confidence: 92%

Female bladder neck dysfunction—A video‐urodynamic diagnosis among women with voiding dysfunction

Ong¹,

Lee

Kuo

2020

LUTS

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Objective To investigate bladder neck dysfunction (BND) in women with voiding dysfunction by video‐urodynamic study (VUDS) and to examine the therapeutic results of different BND subtypes. Materials and Methods We retrospectively reviewed consecutive women who had undergone VUDS for investigation of voiding dysfunction at our institution. The diagnosis of BND was made based on a nonfunneling bladder neck with or without high voiding detrusor pressure. Patients diagnosed as BND were retrieved, and the urodynamic parameters were compared with patients with dysfunctional voiding (DV) and other bladder outlet obstructions (BOO). Results Among 810 women with bladder outlet dysfunction, BND was noted in 100 (12.3%), poor pelvic floor relaxation in 336 (41.5%), DV in 325 (40.1%), cystocele in 19 (2%), and urethral stricture in 30 (4%). Compared with the normal tracing group, BND patients had a significantly smaller volume of bladder filling sensation (included first sensation of filling, full sensation and cystometric bladder capaicity) and a greater BOO index (BOOI) (all P < .05). Detrusor overactivity was noted in 46 (46%) BND patients. These urodynamic parameters in BND were not significantly different from patients with DV or other BOO. High‐pressure BND had a greater BOOI, but low‐pressure BND had a lower voiding efficiency. Both alpha‐blocker therapy and transurethral incision of the bladder neck improved uroflow parameters in BND patients. Conclusions BND includes 12.3% of women with bladder outlet dysfunction. High‐pressure BND can cause anatomical BOO, whereas low‐pressure BND is likely to affect micturition through inhibiting detrusor contractility. VUDS is the mainstay diagnostic tool to diagnose BND in women.

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An Increase of Neuropeptide Y But Not Nitric Oxide Synthase-Immunoreactive Nerves in the Bladder Neck from Male Patients with Bladder Neck Dyssynergia

Abstract: It is suggested that the increase in density of protein gene product 9.5- and neuropeptide Y-immunoreactive nerves, part of the sympathetic contractile system of the bladder neck, may exacerbate bladder outlet obstruction and thus play a role in the pathogenesis of BND.

Cited by 54 publications

References 27 publications

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Female bladder neck dysfunction—A video‐urodynamic diagnosis among women with voiding dysfunction

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