An informative review on solid dispersion

Kumar, Rajiv; Singh, A.; Salwan, Rajan; Bhanot, None Ritesh; Rahar, Sandeep; Dhawan, R.K.

doi:10.30574/gscbps.2023.22.1.0498

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…The crystalline condition and degree of pharmaceuticals are uniquely characterized. Indirectly, the quantity of amorphous narcotics can be deduced from the sample's degree of crystallinity 79 .…”

Section: Solid Dispersions Characterizationmentioning

confidence: 99%

Solid dispersion: application and limitations

Mohammed,

Alfahad,

Qazzaz

2024

J. Drug Delivery Ther.

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Solubility and dissolution rate are essential factors in the bioavailability of a drug. The drug must be well-soluble in water to have good bioavailability. Solid dispersion is among the most widely used and effective methods for increasing solubility and releasing inadequately water-soluble medications. Solid dispersion requires the choice of a suitable carrier for the right active pharmaceutical ingredients and the proper techniques for preparing solid dispersions. The reliable dispersion system is designed in various ways to achieve the goal and avoid the accompanying obstacles. Keywords: solid dispersion, solubility, solvent evaporation, lyophilization, generation, methods

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Section: Solid Dispersions Characterizationmentioning

confidence: 99%

Solid dispersion: application and limitations

Mohammed,

Alfahad,

Qazzaz

2024

J. Drug Delivery Ther.

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“…Achieving complete removal is exceedingly difficult, necessitating an increase in evaporation temperature. However, the utilization of high temperatures accelerates phase separation due to the enhanced mobility of drug molecules and polymers [ 149 ]. The solvent used in this method must be non-toxic and have sufficient solubility for the drug and carrier.…”

Section: Preparation Of Asdmentioning

confidence: 99%

Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer

Budiman,

Handini,

Muslimah

et al. 2023

Polymers

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Cancer treatment has improved over the past decades, but a major challenge lies in drug formulation, specifically for oral administration. Most anticancer drugs have poor water solubility which can affect their bioavailability. This causes suboptimal pharmacokinetic performance, resulting in limited efficacy and safety when administered orally. As a result, it is essential to develop a strategy to modify the solubility of anticancer drugs in oral formulations to improve their efficacy and safety. A promising approach that can be implemented is amorphous solid dispersion (ASD) which can enhance the aqueous solubility and bioavailability of poorly water-soluble drugs. The addition of a polymer can cause stability in the formulations and maintain a high supersaturation in bulk medium. Therefore, this study aimed to summarize and elucidate the mechanisms and impact of an amorphous solid dispersion system on cancer therapy. To gather relevant information, a comprehensive search was conducted using keywords such as “anticancer drug” and “amorphous solid dispersion” in the PubMed, Scopus, and Google Scholar databases. The review provides an overview and discussion of the issues related to the ASD system used to improve the bioavailability of anticancer drugs based on molecular pharmaceutics. A thorough understanding of anticancer drugs in this system at a molecular level is imperative for the rational design of the products.

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