An Injectable Rapid‐Adhesion and Anti‐Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing (Adv. Funct. Mater. 46/2022)

Bian, Shaoquan; Hao, Liuzhi; Qiu, Xin; Jun, Wu; Chang, Hudong; Kuang, Guan‐Ming; Zhang, Sheng; Hu, Xiaohua; Dai, Yakang; Zhang, Zhou; Huang, Fangli; Li, Chun; Zou, Xuenong; Liu, Wenguang; Lu, Willima W.; Pan, Haobo; Zhao, Xiao‐Li

doi:10.1002/adfm.202270260

Cited by 19 publications

(34 citation statements)

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“…These results are consistent with the volume change of the composite hydrogels (Figure 3e). Most anti‐swelling hydrogels in the previous studies suffer from loss of mechanical properties while maintaining a low swelling rate 25–29 . As revealed in Figure 3f, while the FC γ‐PGA/PVA hydrogel exhibits excellent anti‐swelling properties, its mechanical properties are no weaker than those of most reported hydrogels.…”

Section: Resultsmentioning

confidence: 85%

Tough and anti‐swelling γ‐polyglutamic acid/polyvinyl alcohol hydrogels for wearable sensors

Zheng

Zhang

Chen

et al. 2023

J of Applied Polymer Sci

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Hydrogels are widely used in biomedicine, wearable electronics and other fields due to their flexibility and high water content. However, hydrogels prepared by traditional methods generally suffer from swelling in humid environments, which greatly limits their development. This is because most hydrogels are prepared in a non-swollen equilibrium state. This work introduces a method based on directional crystallization to adjust the mechanical and anti-swelling properties of γ-polyglutamic acid/polyvinyl alcohol (γ-PGA/PVA) hydrogels. The results show that the directional crystallization method can effectively improve the antiswelling performance of the hydrogel. After the directional crystallization process for three times, the γ-PGA/PVA hydrogel can remain stable in HCl-Tris solution up to 2 months, indicating its good anti-swelling properties. The morphology, structure and molecular composition of γ-PGA/PVA hydrogels were systematically studied, and their anti-swelling mechanism was also investigated. In addition, the γ-PGA/PVA hydrogel exhibits good response to human motion, opening up new avenues in the field of wearable sensors.

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Section: Resultsmentioning

confidence: 85%

Tough and anti‐swelling γ‐polyglutamic acid/polyvinyl alcohol hydrogels for wearable sensors

Zheng

Zhang

Chen

et al. 2023

J of Applied Polymer Sci

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“…The red star represented LEP‐GA bioadhesive. Numbers 1 to 10 represented LFe‐CMC‐MC, [ 36 ] UIHA, [ 37 ] γ ‐PGA/P‐N/CG15, [ 8 ] Glycopolypeptide, [ 11 ] GelDA/DA–PPy, [ 38 ] LAB2.0, [ 39 ] PFN2H1, [ 15 ] HA‐CNB, [ 1 ] CoSt, [ 40 ] and HPC, [ 41 ] respectively. g) Schematic illustration of the adhesive movement during joint motion.…”

Section: Resultsmentioning

confidence: 99%

“…[ 11 ] Furthermore, synthetic polymer adhesive hydrogels also have been extensively investigated recently. [ 12–14 ] However, drawbacks still existed to limit their further clinical translation, such as complex preparation procedures, [ 1 ] ex‐situ formation causing inadaptability to wound contours, [ 3 ] free radical toxicity during ultraviolet (UV) solidification, [ 15 ] and bioinert properties restraining tissue regeneration. [ 16 ] Therefore, exploring the bionontoxic and flexible adhesive alternatives that could strongly adhere to tissue in situ, withstand frequent mechanical movements and moist bleeding physiological environment, and promote tissue regeneration, is of great clinical significance.…”

Section: Introductionmentioning

confidence: 99%

Engineered Bicomponent Adhesives with Instantaneous and Superior Adhesion Performance for Wound Sealing and Healing Applications

Zhao

Sun

et al. 2023

Adv Funct Materials

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Surgical adhesives are playing an important role in wound repair and emergency hemostasis in clinical treatment. However, the development of strong bioglue with rapid in situ adhesion, durable adhesiveness, and flexibility in dynamic and moist physiological environments is still challenging. Herein, a new type of biosynthetic protein bioadhesives with superior adhesion performance is reported by developing a protein aldimine condensation strategy. Lysine‐rich recombinant proteins are designed and massively biosynthesized to instantaneously react with aldehyde cross‐linkers to realize in situ strong adhesion. The obtained bioadhesives show an ultra‐high adhesion strength of ≈101.6 kPa on porcine skin, outperforming extant clinical bioglues. In addition, they possess super biocompatibility, flexibility, biodegradability, and compliance with the tissues. Owing to the strong and instantaneous adhesion properties, the bioadhesives are qualified for dynamic wound closure, facilitating wound repair, and noncompressible hemorrhage. Importantly, they can be industrially encapsulated into custom‐made cartridge delivery tubes at low cost for clinical use. Therefore, biosynthetic bioadhesives have great potential for biological applications and are capable of scaling up to the industrial level for clinical transformation, which will be a successful paradigm for reforming existing clinical products.

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Section: Introductionmentioning

confidence: 99%

“…Inspired by marine mussels, sandcastle worms, tree frogs, clams, and geckos, several methods were proposed to overcome surface water, including polyelectrolyte condensation, catechol adhesion, dry hydrogel band absorption, etc. 6,7 Recently, the design of bioadhesives for applications in wet environments mainly include hydrophobic 8,9 and hydrophilic strategy. 10,11 For hydrophobic strategy, the hydrophobicity of polymer can eliminate hydrated water at the interface, resulting in sufficient contact between active groups of hydrophobic polymer and substrate.…”

Section: Introductionmentioning

confidence: 99%

Diatom-Inspired Bionic Hydrophilic Polysaccharide Adhesive for Rapid Sealing Hemostasis

Sun,

Li,

et al. 2023

ACS Nano

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Diatoms are typical marine biofouling organisms that secrete extracellular polymers (EPS) to achieve strong underwater adhesion. Here, we report a diatom-inspired bionic hydrophilic polysaccharide adhesive composed of diatom biosilica (DB) and bletilla striata polysaccharide (BSP) for rapid sealing hemostasis. The hierarchical porous structure of DB with rich surface silanol groups provides a strong anchored interface effect for BSP, which can significantly enhance cross-linking density and interaction strength of the hydrophilic macromolecular network. BSP/DB adhesive offers 6 times greater mechanical strength and viscosity over BSP under different temperature conditions. The aggregation effect of DBs interface for BSP avoided the washout of BSP/DB adhesive during application in a wet environment before cross-linking occurs. This strengthened the adhesion ability of BSP/DB adhesive to biological tissue that brought out complete sealing hemostasis without blood loss in a rat liver injury model. The dry BSP/DB prepared by lyophilization inherited excellent clotting ability of BSP/DB adhesive, which could realize rapidly the cruor of anticoagulant whole blood within 1 min. The results of animal studies confirmed that dry BSP/DB exhibited superior hemostatic performance over silicate-based inorganic Quikclot, in terms of hemostatic rate, blood loss, dosage, and multiscroll wound closure.

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An Injectable Rapid‐Adhesion and Anti‐Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing (Adv. Funct. Mater. 46/2022)

Cited by 19 publications

References 0 publications

Tough and anti‐swelling γ‐polyglutamic acid/polyvinyl alcohol hydrogels for wearable sensors

Tough and anti‐swelling γ‐polyglutamic acid/polyvinyl alcohol hydrogels for wearable sensors

Engineered Bicomponent Adhesives with Instantaneous and Superior Adhesion Performance for Wound Sealing and Healing Applications

Diatom-Inspired Bionic Hydrophilic Polysaccharide Adhesive for Rapid Sealing Hemostasis

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