An insight of pharmacognostic study and phytopharmacology of Aquilaria agallocha

Alam, Janey; Mujahid, Md.; Badr, Badruddeen; Rahman, Md. Azizur; Akhtar, Jamal; Khalid, Mohmmad; Jahan, Yasmeen; Basit, Abdul W.; Khan, Akhlaque; Shawwal, Mohd; Iqbal, Shoiab Shadab

doi:10.7324/japs.2015.50827

Cited by 24 publications

(13 citation statements)

References 30 publications

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“…Although earlier literature concentrated on the phytochemistry of the resinous wood, and to some extent the oil produced from the resinous wood (Ishihara et al, 1991a;Ishihara et al, 1991b;Jain, 1959;Nakanishi et al, 1981;Nakanishi et al, 1983;Nakanishi et al, 1984;Varma et al, 1965;Yoneda et al, 1984), the review literature on current work related to the compounds and bioactivities of the different parts of the agarwood plant is very limited, with existing publications focused on specific species, namely, Aquilaria agallocha (Alam, 2015) and Aquilaria sinensis . Another review attempted to report the pharmacological properties of Aquilaria spp., but provided limited information (Jok, 2015).…”

Section: Discussionmentioning

confidence: 98%

Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology

Hashim

Kerr

Abbas

et al. 2016

Journal of Ethnopharmacology

180

127

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Section: Discussionmentioning

confidence: 98%

Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology

Hashim

Kerr

Abbas

et al. 2016

Journal of Ethnopharmacology

180

127

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“…The plant A. agallocha has several pharmacological activities and shows antioxidant, antidiabetic, analgesic, antipyretic, anti-inflammatory, antihistaminic, laxative, anticancerous, antidiarrhoeal, antidiabetic, antihistaminic, antimicrobial, antibacterial, anxiolytic, sedative effect, anticonvulsant and ulcer protective activities 17 . Hence, present study was undertaken to evaluate the hepatoprotective potential of ethanolic extract of A. agallocha leaves against paracetamol (PCM) induced hepatotoxicity in SD rats, as the drugs having antioxidant and antiulcer activities can show hepatoprotective activity too.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective potential of ethanolic extract of Aquilaria agallocha leaves against paracetamol induced hepatotoxicity in SD rats

Alam

Mujahid

Badruddeen

et al. 2017

Journal of Traditional and Complementary Medicine

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Many traditional systems of medicines employ herbal drugs for the hepatoprotection. Aim of the study was designed to evaluate the hepatoprotective potential of ‘ethanolic extract of Aquilaria agallocha (沉香Chen Xiang) leaves' (AAE) against paracetamol (PCM) induced hepatotoxicity in SD rats. Group I animals were treated with 1% CMC for 8 days. Group II, III, IV and V animals were first treated with ‘1% CMC’ 1 ml/kg/day, AAE 200 mg/kg/day, AAE 400 mg/kg/day and silymarin 100 mg/kg/day respectively for 7 days and then, orally administered with PCM 3 g/kg b. wt. on 8th day in a single dose. 24 h after the last dosing by PCM, the blood was obtained through the retro-orbital plexus under light anesthesia and the animals were sacrificed. Hepatoprotective potential was assessed by various biochemical parameters such as ALT, AST, ALP, LDH, bilirubin, cholesterol, TP and ALB. Group IV rats showed significant (p < 0.01) decrease in ALT, AST, ALP, LDH, cholesterol, bilirubin, liver wt. and relative liver wt. levels while significant (p < 0.01) increase in final b. wt., TP and ALB levels as compared to group II rats. Hepatoprotective potential of AAE 400 mg/kg/day was comparable to that of standard drug silymarin 100 mg/kg/day. Results of the study were well supported by the histopathological observations. This study confirms that AAE possesses hepatoprotective potential comparable to that of standard drug silymarin as it exhibited comparable protective potential against PCM induced hepatotoxicity in SD rats.

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“…The fragrant resin is usually used as perfumes, incense in religious ceremonies, and traditional medicines. Alam et al [9] reported that Aquilaria agallocha leaves extract can be used as a laxative and some of its other beneficial properties are antimicrobial, antioxidant and antidiabetic.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Enzymatic Pre-Treatment in Agarwood Oil Extraction

Rahim¹,

Kadri²,

Harun³

2019

Int. J. Adv. Sci. Eng. Inf. Technol.

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Agarwood oil was extracted from a pre-treated agarwood chip soaked in a specific enzyme concentration of 1 %, 3 % and 5 % respectively. The effect of soaking time was also investigated by applying soaking period in the range of 3 to 14 days. Hydrodistillation was carried out using the Clevenger-type apparatus to obtain the essential oil of agarwood chips. Subsequently the quality of the oil and the identification of its oil compounds were analyzed using GC-MS. The morphology of agarwood chips prior to hydrodistillation was characterized using scanning electron microscope (SEM). The SEM results of enzymatic pre-treated sample showed an obvious change in the cell morphology as compared to the sample with standard soaking of 6 days. The highest yield of oil with the amount of 0.125 % is produced from the sample pre-treated with 3 % enzyme concentration as compared to 0.065 % of oil yield from the non-pre-treated sample employing similar soaking days. The GC-MS analysis revealed a total of 335 compounds from all samples of agarwood oil and similar compounds were found in the standard soaking and enzymatic pre-treated samples. Caryophyllene, Gurjunene, and Alloaromadendrene that contributes to the unique odour of agarwood oil are found mostly in all samples. Thus, the enzymatic pre-treatment indicates a comparable yield and oil quality and it is achievable even with a reduced soaking time of 6 days as compared to standard 14 days.

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An insight of pharmacognostic study and phytopharmacology of Aquilaria agallocha

Cited by 24 publications

References 30 publications

Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology

Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology

Hepatoprotective potential of ethanolic extract of Aquilaria agallocha leaves against paracetamol induced hepatotoxicity in SD rats

The Effect of Enzymatic Pre-Treatment in Agarwood Oil Extraction

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