An interface finite element model can be used to predict healing outcome of bone fractures

Alierta, J. A.; Pérez, M.Á.; García-Aznar, J.M.

doi:10.1016/j.jmbbm.2013.09.023

Cited by 21 publications

(17 citation statements)

References 42 publications

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“…exponential and linear patterns of healing in chondrogenesis and bone formation zones of mechanobiological regulations, respectively, presented by Alierta et al (2014).…”

Section: Mechanical Stimulusmentioning

confidence: 99%

Bone fracture healing in mechanobiological modeling: A review of principles and methods

et al. 2017

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Bone fracture is a very common body injury. The healing process is physiologically complex, involving both biological and mechanical aspects. Following a fracture, cell migration, cell/tissue differentiation, tissue synthesis, and cytokine and growth factor release occur, regulated by the mechanical environment. Over the past decade, bone healing simulation and modeling has been employed to understand its details and mechanisms, to investigate specific clinical questions, and to design healing strategies. The goal of this effort is to review the history and the most recent work in bone healing simulations with an emphasis on both biological and mechanical properties. Therefore, we provide a brief review of the biology of bone fracture repair, followed by an outline of the key growth factors and mechanical factors influencing it. We then compare different methodologies of bone healing simulation, including conceptual modeling (qualitative modeling of bone healing to understand the general mechanisms), biological modeling (considering only the biological factors and processes), and mechanobiological modeling (considering both biological aspects and mechanical environment). Finally we evaluate different components and clinical applications of bone healing simulation such as mechanical stimuli, phases of bone healing, and angiogenesis.

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“…exponential and linear patterns of healing in chondrogenesis and bone formation zones of mechanobiological regulations, respectively, presented by Alierta et al (2014).…”

Section: Mechanical Stimulusmentioning

confidence: 99%

Bone fracture healing in mechanobiological modeling: A review of principles and methods

et al. 2017

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“…Probably, this kind of fractures has not been studied by means of Finite Element Analysis (FEA) due to the complexity of using current bone healing algorithms in real 3D geometries. However, recently, Alierta et al(2014) have presented a novel mechanistic phenomenological approach for modelling bone fracture healing specially adequated for the simulation of realistic 3D geometries. Actually, this model allows the simulation of bone fracture healing for realistic bone fracture geometries (oblique, comminuted, spiral and compound).…”

Section: Introductionmentioning

confidence: 99%

Biomechanical assessment and clinical analysis of different intramedullary nailing systems for oblique fractures

Alierta¹,

Pérez

Seral

et al. 2015

Computer Methods in Biomechanics and Biomedical Engineering

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The aim of this study is to evaluate the fracture union or non-union for a specific patient that presented oblique fractures in tibia and fibula, using a mechanistic-based bone healing model. Normally, this kind of fractures can be treated through an intramedullary nail using two possible configurations that depends on the mechanical stabilisation: static and dynamic. Both cases are simulated under different fracture geometries in order to understand the effect of the mechanical stabilisation on the fracture healing outcome. The results of both simulations are in good agreement with previous clinical experience. From the results, it is demonstrated that the dynamization of the fracture improves healing in comparison with a static or rigid fixation of the fracture. This work shows the versatility and potential of a mechanistic-based bone healing model to predict the final outcome (union, non-union, delayed union) of realistic 3D fractures where even more than one bone is involved.

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“…Although there are a lot of factors that influence fracture healing, experimental studies have shown that interfragmentary movement is one of the main regulators of the course of bone healing [22]. Alierta et al proposed a combined repair-failure mechanistic computational FE model in order to describe bone fracture healing [22]. The bone fracture gap was mod- [20].…”

Section: Bone Remodeling and Fracture Healingmentioning

confidence: 99%

“…For instance, in some investigations, bone healing was only being regulated by mechanical factors [22,24], while in real life, bone healing is also regulated by other factors, such as biological, genetic and chemical factors. Another important assumption that has been made by investigators is the modeling and prediction of callus growth in the FEM simulations [22,24]. These assumptions need to be addressed in any future work in order to improve the predictive accuracy of the bone fracture healing process.…”

Section: Future Science Groupmentioning

confidence: 99%

Finite-Element Modeling and Analysis in Nanomedicine and Dentistry

2014

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This article aims to provide a brief background to the current applications of finite-element analysis (FEA) in nanomedicine and dentistry. FEA was introduced in orthopedic biomechanics in the 1970s in order to assess the stresses and deformation in human bones during functional loadings and in the design and analysis of implants. Since then, it has been applied with great frequency in orthopedics and dentistry in order to analyze issues such as implant design, bone remodeling and fracture healing, the mechanical properties of biomedical coatings on implants and the interactions at the bone-implant interface. More recently, FEA has been used in nanomedicine to study the mechanics of a single cell and to gain fundamental insights into how the particulate nature of blood influences nanoparticle delivery.

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An interface finite element model can be used to predict healing outcome of bone fractures

Cited by 21 publications

References 42 publications

Bone fracture healing in mechanobiological modeling: A review of principles and methods

Bone fracture healing in mechanobiological modeling: A review of principles and methods

Biomechanical assessment and clinical analysis of different intramedullary nailing systems for oblique fractures

Finite-Element Modeling and Analysis in Nanomedicine and Dentistry

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