An intraoral model used for studies of fluoride incorporation in enamel

Koulourides, T.; Phantumvanit, Prathip; Munksgaard, Erik Christian; Housch, T.

doi:10.1111/j.1600-0714.1974.tb01710.x

Cited by 169 publications

(147 citation statements)

References 16 publications

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“…Peripheral Vascular, Tempe, AZ, USA) to encourage plaque formation [29,30]. Specimens were mounted such that the surface was flush with the buccal flange surface and were luted in place using a light cured dental composite (Triad VLC material, Dentsply Int., York, PA, USA).…”

Section: In Situ Remineralisation Modelmentioning

confidence: 99%

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Parkinson¹,

Burnett²,

Creeth³

et al. 2018

Journal of Dentistry

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Objectives: To compare and explore the dose-response of phytate-containing 1150 ppm fluoride toothpastes on model caries lesions and to determine the impact of zinc ions.Methods: This was a single-centre, randomised, blinded (examiner/laboratory analyst), sixtreatment, four-period crossover, in situ study in adults with a removable bilateral maxillary partial denture. Study treatments were toothpastes containing: 0.425% phytate/F; 0.85% phytate/F; 0.85% phytate/Zn/F; F-only; Zn/F and a 0% F placebo. Where present, F was 1150 ppm as NaF; Zn was 0.3% Clinical significance: Toothpastes may contain therapeutic or cosmetic agents that could interfere with fluoride's caries prevention efficacy. The present in situ caries study has demonstrated that phytate, added to provide enhanced extrinsic stain removal/prevention, and zinc, added to inhibit malodour, do not impair fluoride efficacy.

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Section: In Situ Remineralisation Modelmentioning

confidence: 99%

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Parkinson¹,

Burnett²,

Creeth³

et al. 2018

Journal of Dentistry

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“…The designs of in situ models are quite varied, ranging from the classical partial denture model (intra-oral cariogenicity test) as RESEARCH nutrition described by Koulourides and co-workers, 23 to fairly sophisticated models such as the intra-oral single-section model. 24 In situ model systems can be broadly classified based on the physical design of the model, the type of hard tissue substrate and the method of assessing mineral status 18 grouped in situ model systems into three categories:…”

Section: Physical Designmentioning

confidence: 99%

Modern methods for assessing the cariogenic and erosive potential of foods

Curzon¹,

Hefferren²

2001

Br Dent J

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RESEARCH nutrition and plaque pH, but also determined that enamel demineralisation should be further developed as a model. Dental erosion was not perceived as a problem, at that time, and was not mentioned in the deliberations. The animal model has continued to be used. Researchers, and other authorities, wishing to determine the cariogenic potential of foods, drinks and some oral medicines, have used the plaque pH models. The enamel demineralisation model, often called the intra-oral cariogenicity test (ICT), has been further developed since the San Antonio conference, so that it is now widely used for cariogenicity testing. Variants of the ICT, also known as the in situ model, are now being developed to test foods and drinks for erosion, but need evaluation.Accordingly on 8 and 9 November 1999, a group of dental scientists and clinicians met in London (UK) to review the San Antonio recommendations, reassess them and draw up revised guidelines. The aim was to determine which methods are currently suitable as research tools but also for regulatory assessments.The conference was directed by Professor John Hefferren, previously Chairman of the San Antonio meeting, and who lead the discussions of all delegates. In each of the four workshop sessions, under the guidance of a chairman, a presenter gave a prepared report to update the information on a particular method or group of methodologies. Each presentation was then commented on by a reactor and then by open discussion of all delegates. On the second day individual workshops were held involving small groups of delegates and working documents prepared presenting draft new guidelines.In a final plenary session all of the working documents were reconsidered and refined. Subsequently, the chairman of each working group was asked to prepare a draft document that was then circulated and commented upon by all delegates. After final editing the consensus opinions are presented in this document. Organisation of the textThe following text is organised to consider the four main groups of models for cariogenicity and erosion evaluation. The first is the animal model, usually based on the rat using an automatic feeding machine. The second group concerns the various approaches to assess plaque pH responses to the use of foods. The third model is the enamel demineralisation method and the fourth is that concerning assessment of the erosive potential of foods. Readers should consider this document in association with the San Antonio publication 1 which gives the original guidelines for methodologies in great detail. Herein only suggested changes or comments on the original have been made. Animal models:Workshop group: M. E. J. Curzon, J. J. Hefferren, P. M. Marsh and P. Mtolo The group agreed that animal testing (usually with the laboratory rat) remains an important model to assess cariostatic and cario-

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“…Therefore, erosive and erosive/abrasive alterations of dental hard tissues are mostly investigated either in in vitro studies or in in situ studies. In the latter ones, enamel or dentin specimens are extra-orally or sometimes intra-orally subjected to erosive challenges, worn in the oral cavity according to the intra-oral cariogenicity test developed by [9][10][11] [9][10][11] and finally assessed in the labora-tory for hard tissue loss and surface alterations.…”

mentioning

confidence: 99%

Methods for Assessment of Dental Erosion

Attin

Wegehaupt²

2014

Monographs in Oral Science

126

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Various assessment techniques have been applied to evaluate the loss of dental hard tissue and the surface-softened zone in enamel induced by erosive challenges. In this chapter, the most frequently adopted techniques for analyzing the erosively altered dental hard tissues are reviewed, such as profilometry, measuring microscope techniques, microradiography, scanning electron microscopy, atom force microscopy, nano-and microhardness tests and iodide permeability test. Moreover, methods for chemical analysis of minerals dissolved from dental hard tissue are discussed. It becomes evident that the complex nature of erosive mineral loss and dissolution might not be comprehended by a single technique, but needs application of different approaches for full understanding. Chapter 10Lussi A (ed): Dental Erosion. Monogr Oral Sci. Basel, Karger, 2006, vol 20, pp 152-172 Methods for Assessment of Dental Erosion Thomas Attin, Florian Just WegehauptCenter for Dental Medicine, Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Zürich, Switzerland AbstractVarious assessment techniques have been applied to evaluate the loss of dental hard tissue and the surface-softened zone in enamel induced by erosive challenges. In this chapter, the most frequently adopted techniques for analyzing the erosively altered dental hard tissues are reviewed, such as profilometry, microradiography, scanning electron microscopy, atom force microscopy, nano-and microhardness tests and iodide permeability test. Moreover, methods for chemical analysis of minerals dissolved from dental hard tissue are discussed. It becomes evident that the complex nature of erosive mineral loss and dissolution might not be comprehended by a single technique, but needs application of different approaches for full understanding. Copyright © 2006 S. Karger AG, Basel Acid attack leads to an irreversible loss of the outermost enamel and dentin layers and to partial demineralization (softening) of the tooth surface. In enamel, the thickness of the softened layer is estimated to be 2-5 tJm [1,2] [1, 2]. The softened eroded tooth surface is highly susceptible to abrasive wear, and mechanical impacts such as toothbrushing can easily remove the superficially demineralized dental hard tissue [3][4][5] [3][4][5]. For simulating intra-oral erosion as closely as possible, it is desirable to assess the erosive effects on native tooth surfaces. Most of the methods described below need polished surfaces for precise assessment of the erosively induced defects or for creating reference surfaces, which means that the natural, often fluoridated surface of the tooth has to be removed. However, it should be considered that in the case of intra-oral erosion the outermost surface layers are also continuously removed by the acid attack, so that a 'polished' surface is Attin 2 cre-ated. When monitoring of erosive surface alterations within a period of time is performed, it could become necessary to fix a specimen in the measuring device i...

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An intraoral model used for studies of fluoride incorporation in enamel

Cited by 169 publications

References 16 publications

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Modern methods for assessing the cariogenic and erosive potential of foods

Methods for Assessment of Dental Erosion

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