An intratumoral injectable nanozyme hydrogel for hypoxia-resistant thermoradiotherapy

Wang, Ziqi; Zeng, Wen; Chen, Zhiran; Suo, Weilong; Hong, Quan; Tan, Zhijie

doi:10.1016/j.colsurfb.2021.112026

Cited by 20 publications

(17 citation statements)

References 28 publications

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“…Schotman and Dankers recently provided an insightful review on this issue, pointing out the importance of hydrogel mechanical properties and degradation, administered volume, as well as biological factors such as tissue contractions and hydrogel-tissue affinity. Drug release kinetics of therapeutics from hydrogels depend on the hydrogel pore size, drug size, and solubility, and drug–matrix interactions. ,,, Drug release mechanisms can range from simple Fickian diffusion , to sophisticated stimuli-responsive or on-demand release systems. − Hydrogels equipped with complementary oligonucleotide sequences or antibodies have been proposed as reloadable depots that can actively capture systemically administered drugs from the bloodstream. − The longevity of hydrogels is also exploited for the local delivery of excitable particles for repeated photothermal or brachytherapy against cancer. − …”

Section: Applications Of Self-healing Injectable Hydrogels For Tissue...mentioning

confidence: 99%

“…(D) Infrared image of an intratumorally administered injectable hydrogel containing excitable nanoparticles for photothermal therapy of hypoxia-resistant breast tumors. Reproduced with permission from ref . Copyright 2021 Elsevier.…”

Section: Applications Of Self-healing Injectable Hydrogels For Tissue...mentioning

confidence: 99%

“…Many self-healing hydrogels for intratumoral injection are designed for pH-responsive release, exploiting the acidic extracellular pH in tumors. ,− Cancer cells are often more susceptible to short-term high-dose drug bursts than long-term constant doses. Hence, hydrogels with magnetic, ultrasound, or photosensitive release mechanisms have been designed to induce burst-type drug release triggered by external stimuli. ,,,, Injectable hydrogels loaded with magnetic or excitable nanoparticles are employed to induce intratumoral magnetic hyperthermia or facilitate photothermal therapy, ,,− as shown in Figure D. Injectable hydrogels loaded with radioactive iodine-131 have been investigated for intratumoral radiotherapy (brachytherapy), ,, while radiopaque hydrogels are used as injectable tissue markers − or spacers to protect nearby tissues and organs. − A key advantage is that hydrogels can be designed to remain intact over several weeks and can therefore be used for repeated periodic treatments.…”

Section: Applications Of Self-healing Injectable Hydrogels For Tissue...mentioning

confidence: 99%

“…Hence, hydrogels with magnetic, ultrasound, or photosensitive release mechanisms have been designed to induce burst-type drug release triggered by external stimuli. 119,295,321,455,456 Injectable hydrogels loaded with magnetic or excitable nanoparticles are employed to induce intratumoral magnetic hyperthermia or facilitate photothermal therapy, 295,321,457−461 as shown in Figure 8D. Injectable hydrogels loaded with radioactive iodine-131 have been investigated for intratumoral radiotherapy (brachytherapy), 322,462,463 while radiopaque hydrogels are used as injectable tissue markers 464−466 or spacers to protect nearby tissues and organs.…”

Section: Anticancer Strategies and Immunomodulationmentioning

confidence: 99%

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Self-Healing Injectable Hydrogels for Tissue Regeneration

et al. 2022

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Biomaterials with the ability to self-heal and recover their structural integrity offer many advantages for applications in biomedicine. The past decade has witnessed the rapid emergence of a new class of self-healing biomaterials commonly termed injectable, or printable in the context of 3D printing. These self-healing injectable biomaterials, mostly hydrogels and other soft condensed matter based on reversible chemistry, are able to temporarily fluidize under shear stress and subsequently recover their original mechanical properties. Self-healing injectable hydrogels offer distinct advantages compared to traditional biomaterials. Most notably, they can be administered in a locally targeted and minimally invasive manner through a narrow syringe without the need for invasive surgery. Their moldability allows for a patient-specific intervention and shows great prospects for personalized medicine. Injected hydrogels can facilitate tissue regeneration in multiple ways owing to their viscoelastic and diffusive nature, ranging from simple mechanical support, spatiotemporally controlled delivery of cells or therapeutics, to local recruitment and modulation of host cells to promote tissue regeneration. Consequently, self-healing injectable hydrogels have been at the forefront of many cutting-edge tissue regeneration strategies. This study provides a critical review of the current state of self-healing injectable hydrogels for tissue regeneration. As key challenges toward further maturation of this exciting research field, we identify (i) the trade-off between the self-healing and injectability of hydrogels vs their physical stability, (ii) the lack of consensus on rheological characterization and quantitative benchmarks for self-healing injectable hydrogels, particularly regarding the capillary flow in syringes, and (iii) practical limitations regarding translation toward therapeutically effective formulations for regeneration of specific tissues. Hence, here we (i) review chemical and physical design strategies for self-healing injectable hydrogels, (ii) provide a practical guide for their rheological analysis, and (iii) showcase their applicability for regeneration of various tissues and 3D printing of complex tissues and organoids.

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Section: Applications Of Self-healing Injectable Hydrogels For Tissue...mentioning

confidence: 99%

Section: Applications Of Self-healing Injectable Hydrogels For Tissue...mentioning

confidence: 99%

Section: Applications Of Self-healing Injectable Hydrogels For Tissue...mentioning

confidence: 99%

Section: Anticancer Strategies and Immunomodulationmentioning

confidence: 99%

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Self-Healing Injectable Hydrogels for Tissue Regeneration

et al. 2022

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“…Platelets can also interact with tumor cells by directly binding or secreting cytokines. Taking advantage of the natural pathophysiological affinity and targeting ability of platelets to tumors, a biomimetic drug delivery system based on platelet membranes has also been developed for tumor treatment ( 25 , 26 ). Compared with artificial drug delivery platforms, they are less likely to cause clearance reactions, so vesicles administered with the platelet membrane itself provide a better prospect for drug delivery ( 27 , 28 ).…”

Section: Introductionmentioning

confidence: 99%

Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy

et al. 2021

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Continuous high doses of radiation can cause irreversible side effects and radiation resistance; thus, advanced radiosensitizers are urgently needed. To overcome this problem, we developed a nano platelet radiosensitization system (PCA) by coating the chemotherapeutic drug cisplatin (CDDP) loaded gold nanocages (AuNs) within the platelet membrane. The developed PCA system may enable AuNs to have immune escape and targeting capabilities. After administration, PCA will actively target tumor cells and avoid being cleared by the immune system. Subsequently, CDDP, which destroys tumor cell DNA, can not only kill tumor cells directly but also combine with AuNs, which deposit radiation energy into tumor tissues, reducing RT resistance. In vivo and in vitro studies revealed that the combination of PCA with RT (2Gy) efficiently inhibits tumor proliferation without causing side effects such as inflammation. To conclude, this is the first attempt to use platelet membranes to correctly transport AuNs while also accomplishing low-dose RT, which could help AuNs-based tumor RT become more effective.

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A Light‐Responsive Injectable Hydrogel with Remodeling Tumor Microenvironment for Light‐Activated Chemodynamic Therapy

Liu

Chen

Huang

et al. 2022

Macromolecular Bioscience

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Chemodynamic therapy (CDT) based on Fenton-like reaction is often limited by the tumor microenvironment (TME), which has insufficient hydrogen peroxide, and single CDT treatment is often less efficacious. To overcome these limitations, a hydrogel-based system is designed to enhance the redox stress (EOH) by loading the composite nanomaterial Cu-Hemin-Au, into the agarose hydrogels. The hydrogels can reach the tumor site upon intratumoral injection, and then coagulate and stay for extended period. Once irradiated with near-infrared light, the Cu-Hemin-Au act as a photothermal agent to convert the light energy into heat, and the EOH gradually heated up and softened, releasing the Cu-Hemin-Au residing in it to achieve photothermal therapy (PTT). Benefiting from the glucose oxidase (GOx)-like activity of the Au nanoparticles, glucose in the tumor cells is largely consumed, and hydrogen peroxide (H 2 O 2 ) is generated in situ, and then Cu-Hemin-Au react with sufficient H 2 O 2 to generate a large amount of reactive oxygen species, which promote the complete inhibition of tumor growth in mice during the treatment cycle. The hydrogel system for the synergistic enhancement of oxidative stress achieves good PTT/CDT synergy, providing a novel inspiration for the next generation of hydrogels for application in antitumor therapy.

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An intratumoral injectable nanozyme hydrogel for hypoxia-resistant thermoradiotherapy

Cited by 20 publications

References 28 publications

Self-Healing Injectable Hydrogels for Tissue Regeneration

Self-Healing Injectable Hydrogels for Tissue Regeneration

Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy

A Light‐Responsive Injectable Hydrogel with Remodeling Tumor Microenvironment for Light‐Activated Chemodynamic Therapy

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