An investigation of electrospun Henna leaves extract-loaded chitosan based nanofibrous mats for skin tissue engineering

Yousefi, Iman; Pakravan, Mehdi; Rahimi, Hoda; Bahador, Abbas; Farshadzadeh, Zahra; Haririan, Ismaeil

doi:10.1016/j.msec.2017.02.076

Cited by 158 publications

(94 citation statements)

References 90 publications

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“…Nevertheless, since NQ14 and chitosan are both hydrophilic materials and NQ14-loaded chitosan membranes were more porous ( Figure 6 ), the free space for diffusion increases, allowing these membranes to retain more water molecules inside the network and, consequently, in their higher swelling degree. These results are in good agreement with literature, where it has been reported that, whether the macromolecular chains of a polymer are fixed by ionic crosslinking or chemical crosslinking, the swelling ability of the polymeric networks is reduced [ 66 , 81 ]. The amount of TPP affected the molecular structure, porosity, surface area and the degree of hydrophilicity of the membranes and consequently their swelling behavior.…”

Section: Resultssupporting

confidence: 92%

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

et al. 2018

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The aim of this paper was to prepare, by the freeze-drying method, ionically crosslinked chitosan membranes with different contents of pentasodium tripolyphosphate (TPP) and loaded with 1,4-naphthoquinone (NQ14) drug, in order to evaluate how the physical crosslinking affects NQ14 release from chitosan membranes for cancer therapy application. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM), swelling degree, and through in vitro drug release and cytotoxicity studies. According to the results, the molecular structure, porosity and hydrophilicity of the chitosan membranes were affected by TPP concentration and, consequently, the NQ14 drug release behavior from the membranes was also affected. The release of NQ14 from crosslinked chitosan membranes decreased when the cross-linker TPP quantity increased. Thus, depending on the TPP amount, the crosslinked chitosan membranes would be a potential delivery system to control the release of NQ14 for cancer therapy application. Lastly, the inhibitory potential of chitosan membranes ionically crosslinked with TPP and loaded with NQ14 against the B16F10 melanoma cell line was confirmed through in vitro cytotoxicity studies assessed via MTT assay. The anti-proliferative effect of prepared membranes was directly related to the amount of cross-linker and among all membranes prepared, such that one crosslinked with 0.3% of TPP may become a potential delivery system for releasing NQ14 drug for cancer therapy.

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Section: Resultssupporting

confidence: 92%

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

et al. 2018

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“…Hydrogen bonds was observed in the FTIR spectra, with atoms that have higher electronegativity, such as fluorine, oxygen, and nitrogen. These bonds were reported in similar researches between PCL and Gt or chitosan . In this research, the existence of nitrogen and oxygen atoms were confirmed by FTIR as it is mentioned in Table .…”

Section: Resultssupporting

confidence: 79%

Fabrication of althea officinalis loaded electrospun nanofibrous scaffold for potential application of skin tissue engineering

Ghaseminezhad

Zare

Lashkarara

et al. 2019

J of Applied Polymer Sci

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The Althea Officinalis (AO) extract is well known as a traditional herbal drug for its wound healing ability owing to the anti-inflammatory and antimicrobial properties. Furthermore, its mucilaginous properties provide moisturizing and nutritional effects on skin cell proliferation. Therefore, AO extract can be applied in the temporary skin substitute for the ability to expedite the therapy duration. In this study, different concentrations of AO extract (0, 5, 10, 15, and 20 wt %) were incorporated into the nanofibrous scaffolds to study their potential for the skin tissue repairing. The desired scaffolds were prepared by electrospinning the blend of poly (ε-caprolactone) and gelatin as a synthesized and natural polymer. The electrospun nanofibers were characterized by SEM, FTIR, DSC, TGA, tensile, AO extract release, and cellular culture tests. This study proposed incorporating the AO extract into the nanofibrous scaffolds for accelerating the skin tissue repairing and the optimized amount of AO extract as about 15% was introduced for offering the most desirable electrospun scaffolds for this application.

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“…compared the antibacterial nature of chitosan/PEO/henna extract (lawsone) and chitosan/PEO electrospun mats against both bacterial strains. They concluded that the mats with Henna extract show more antibacterial activity than chitosan/PEO mat . The antibacterial action of O‐Cmc, ZnO, O‐Cmc/ZnO, lawsone and O‐Cmc/ZnO/Ln NCs with control amoxicillin‐clavulanate against Salmonella typii, Staphylococcus aureus, Pseudomonas aeruginosa and E.coli was shown in Figure .A.…”

Section: Resultsmentioning

confidence: 99%

“…Human skin comprised of soft living tissues that hinder the invasion of harmful microorganisms and function as a defensive layer . Damage of this soft integrated living tissues causes wound and the complex reconstruction process starts immediately with different biochemical stages like blood clotting (hemostasis), inflammation, granulation, proliferation followed remodelling .…”

Section: Introductionmentioning

confidence: 99%

Preparation and In Vitro Biological Evaluation of Lawsone Loaded O‐Carboxymethyl Chitosan/Zinc Oxide Nanocomposite for Wound‐Healing Application

Sakthiguru

Sithique

2020

ChemistrySelect

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A biopolymer based nanocomposite with O‐Carboxymethyl chitosan (O‐Cmc), nano zinc oxide (ZnO) and Lawsone (Ln) with proving advantages in antibacterial wound healing application was prepared. The physiochemical characteristics of the nanocomposite (NCs) was analysed by Fourier Transmission Infrared spectroscopy (FT‐IR), X‐Ray Diffractometer (XRD), Scanning electron Microscopy (SEM), Transmission electron microscope (TEM) and Thermogravimetric analysis (TGA). The biological properties such as anti‐inflammatory, anti‐oxidant activities were investigated in vitro. The nanocomposite also possesses efficient drug encapsulation and releasing profile with greater stability in phosphate buffer saline (PBS) and Dulbecco's minimal essential medium (DMEM). The results of the antibacterial studies show its enhanced bactericidal nature. The results obtained from MTT assay, Ethidium bromide stained fluorescence image and in vitro wound scratch assay show greater cell viability with the closure of scratch wound obviously proves it′s prominent biocompatible, wound closure nature. These biological properties show that the prepared nanocomposite has a greater potential to act as an excellent biomaterial in the field of wound care applications.

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An investigation of electrospun Henna leaves extract-loaded chitosan based nanofibrous mats for skin tissue engineering

Cited by 158 publications

References 90 publications

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

Fabrication of althea officinalis loaded electrospun nanofibrous scaffold for potential application of skin tissue engineering

Preparation and In Vitro Biological Evaluation of Lawsone Loaded O‐Carboxymethyl Chitosan/Zinc Oxide Nanocomposite for Wound‐Healing Application

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