An Investigation of the Impact of Molecular Geometry upon Microcapsule Self-Assembly

Mechanism of Crystalline Dicarboxamide Microsphere Self-Assembly Probed by in Situ Raman Microscopy and Raman Imaging

“…Fortunately, we have been able to learn assembly mechanisms from a variety of biological systems that build functional nanoscale structures . To match the self-organization often seen in biological systems, chemists have synthesized self-assembly systems that mimic the natural systems. − These peptide assemblies mimic biological channels and pore structures. The peptide assemblies may have potential application as drug delivery vehicles into living cells, since the conventional drug carriers need improvement in their stability and control of drug release.…”

“…One of the peptide molecules, dicarboxamide, assembles into crystalline microspheres in an acidic solution. ,,, Protonation to COO - groups in the dicarboxamide triggers the self-assembly by phase transition . In short, the sudden change from soluble (ionic) to insoluble (protonated) states in aqueous solution expels water from the assembled region.…”

Development of a Series of Cross‐Linking Agents that Effectively Stabilize α‐Helical Structures in Various Short Peptides

“…Materials and general procedures: The cross-linking agents 3 and 5 were commercially available, while 4, [14] 6, [15] and 9 [16] had been reported previously. Other cross-linking agents were prepared from their corresponding dicarboxylic acids by the same procedure as described for 1 and 2.…”

Evaluation of novel particles as an inhalation system for GLP‐1

“…Technosphere® technology is a drug delivery platform designed for the pulmonary administration of protein and peptide therapeutics [13][14][15][16][17]. It is based on the novel excipient, fumaryl diketopiperazine (FDKP; figure 1), which has the ability to self-assemble into discrete particles upon precipitation from solution [18][19][20][21][22][23]. These particles are uniform in size, optimized for inhalation into the deep lung (2-5 μm in diameter) and dissolve rapidly at physiological pH [24].…”