An Isolated Peculiar Gianotti-Crosti Rash in the Course of a COVID-19 Episode

Brin, C.; Sohier, Pierre; L’Honneur, Anne-Sophie; Marot, Stéphane; Matar, Stephanie; Aractingi, S.; Dupin, Nicolas

doi:10.2340/00015555-3641

Cited by 19 publications

(15 citation statements)

References 8 publications

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“…Upon reviewing the symptoms, the mother reported that the patient had fever and cough with a positive SARS-CoV-2 RT-PCR. Also, Brin C et al [25] reported that A 23year-old man complained of a rash that appeared two days before seeking medical advice. Three weeks preceding skin symptoms, Although cutaneous manifestations of COVID-19 are rare, all physicians need to be aware of these manifestations for rapid and efficient diagnosis and management of the disease, even in asymptomatic or pauci-symptomatic patients.…”

Section: Discussionmentioning

confidence: 99%

Gianotti-Crosti Syndrome in a Child with Recent Covid-19 Infection: A Case Report

Alqahtani¹,

Shati²,

Alhanshani³

et al. 2021

PJMHS

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Gianotti-Crosti Syndrome is a rare skin disease affecting children at the first years of age. The condition is clinically featured by blisters on the skin of the legs, buttocks and arms. A history of viral infection preceding the disease was reported for many cases. A 12-month-old boy, free of any medical illnesses, was presented with a history of acute-onset rash for five days prior to presentation that was preceded by a history of fever for two days then subsided. The rashes appeared initially on his buttocks, then spread to his upper and lower extremities and trunk. The child had fever, sore throat and coryza symptoms with lethargy. A polymerase chain reaction (PCR) swab was taken to test for SARS-CoV-2, which was positive two weeks before rash onset. All symptoms resolved in 1 week with supportive therapy and the current rashes appeared two weeks later in the patient. Gianotti–Crosti syndrome may follow the active phase of infection for some cases. It should not be misdiagnosed with dermatological simple eruptive disorders. The clinical features for covid-19 associated infection are typical for the well-known clinical picture of the syndrome. The case was reported to improve clinicians’ awareness and help in better understanding and reporting cutaneous manifestations of COVID-19. Keywords: Gianotti-Crosti Syndrome; Infants; Children; covid-19; Corona

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Section: Discussionmentioning

confidence: 99%

Gianotti-Crosti Syndrome in a Child with Recent Covid-19 Infection: A Case Report

Alqahtani¹,

Shati²,

Alhanshani³

et al. 2021

PJMHS

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“…When specified, treatments varied with the use of systemic or topical corticosteroids or/and intravenous or oral antihistamines. 5,[8][9][10] There is a hypothesis that some skin disorders associated with COVID-19 may be a drug-induced reaction. Maculopapular rash is one of the main manifestations of non-immediate hypersensitivity to drugs.…”

Section: Discussionmentioning

confidence: 99%

“…12 However, some reports present histopathology with dense lymphocytic infiltrate in the dermal papilla and perivascular, as well as the absence of eosinophils, which is an atypical drug-induced reaction finding. 8,10 Other reports dismiss this hypothesis due to clinical history, since the rash manifested itself before any drug use. 13 Other reports of skin disorders have also ruled out the drug-induced reaction hypothesis.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Cutaneous Disorders: What’s Being Reported? A Meta-Analysis from Observational Studies and Case Reports

Rocha

Zanuncio

Valadares

et al. 2020

SPDV

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Background: Coronavirus disease (COVID-19) is related to several extrapulmonary disorders; however, little is known about the skin disorders characteristics and prevalence. Objetive: Summarize and evaluate the skin disorders’ characteristics and prevalence reported in the literature. Methods: We conducted a search on PubMed, SciELO and ScienceDirect between 01/01/2020 to 09/28/2020. The target population was patients with skin disorder and a positive diagnosis for COVID-19. All observational studies, research letters, case series and case reports were selected. We evaluated observational studies using Random- effects models to calculate the weighted mean prevalence and 95% confidence interval (CI). We evaluated the case studies using the chi-square test for dichotomous variables and the Mann-Whitney test for continuous variables. Results: Eighty-seven patients from case reports and six observational studies with 363 patients were selected. Eleven types of skin disorders in COVID-19 confirmed patients are described. Skin disorder weighted mean prevalence was 9.9% (95% CI: 3.7-24.1). Maculopapular rash was the most prevalent disorder (37.5%; 95% CI: 21-57%). Latency was significantly lower in patients over 60 years old (p=0.041). Conclusion: Each cutaneous manifestation has its particularities and may or may not accompany other signs and symptoms. It is possible for the elderly to have COVID-19- related skin disorders early.

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“…In some cases, the causal agent remains unknown even after a complete study. 7 The first authors who reported an association between GCS and COVID-19 were Brin et al 8 In their case, the rash appeared 3 weeks after the beginning of the symptoms. In ours, conversely, the onset of the eruption coincided with the initial peak of fever.…”

Section: A Gianotti-crosti-like Eruption In the Setting Of Sars-cov-2 Infectionmentioning

confidence: 99%

A Gianotti‐Crosti ‐like eruption in the setting of SARS‐CoV ‐2 infection

Berna‐Rico

Álvarez-Pinheiro

Burgos-Blasco

et al. 2021

Dermatologic Therapy

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and, especially, the distribution of papules were otherwise similar, and both the COVID-19 infection and the absence of a pharmacological origin seem well documented.In conclusion, we report a case of a Gianotti-Crosti-like eruption in the setting of a COVID-19 infection. This is also a good example of the usefulness of teledermatology, a tool that is playing a major role in the pandemic, breaking down barriers to patient assessment derived from confinement and isolation measures. 9 More reports based on morphology and distribution of COVID-19 skin manifestations could be of great interest in this setting. Though we could not establish a definitive GCS diagnosis, we hope this report could modestly help clinicians to identify atypical presentations of the infection.

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An Isolated Peculiar Gianotti-Crosti Rash in the Course of a COVID-19 Episode

Cited by 19 publications

References 8 publications

Gianotti-Crosti Syndrome in a Child with Recent Covid-19 Infection: A Case Report

Gianotti-Crosti Syndrome in a Child with Recent Covid-19 Infection: A Case Report

COVID-19 and Cutaneous Disorders: What’s Being Reported? A Meta-Analysis from Observational Studies and Case Reports

A Gianotti‐Crosti ‐like eruption in the setting of SARS‐CoV ‐2 infection

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