An outbreak of Pantoea spp. in a neonatal intensive care unit secondary to contaminated parenteral nutrition

Habsah, H.; Mohamed, Zeehaida; Rostenberghe, Hans Van; Noraida, R; Pauzi, W.I. Wan; Fatimah, I.; Rosliza, Abdul Rahman; Sharimah, N Y Nik; Maimunah, H

doi:10.1016/j.jhin.2005.01.004

Cited by 83 publications

(63 citation statements)

References 27 publications

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“…Los casos descritos de infección neonatal por P. agglomerans se han presentado en neonatos a término y pretérminos, ya sea como sepsis tardía o temprana. [36][37][38][39][40][41][42][43][44] Los primeros casos reportados se asociaron a brotes por contaminación de infusiones para nutrición parenteral. 38 Aunque se han descrito infecciones por otros tipos de Pantoea, 45 la infección por P. agglomerans es la más frecuente.…”

Section: Discussionunclassified

“…[36][37][38][39][40][41][42][43][44] Los primeros casos reportados se asociaron a brotes por contaminación de infusiones para nutrición parenteral. 38 Aunque se han descrito infecciones por otros tipos de Pantoea, 45 la infección por P. agglomerans es la más frecuente. En el Cuadro 1 se resumen los casos reportados de sepsis neonatal por esta bacteria con las principales características y se comparan con el caso presentado.…”

Section: Discussionunclassified

“…Aunque no se han establecido los mecanismos de infección de la P. agglomerans, se ha descrito una transmisión vertical en reportes de casos de sepsis neonatal temprana 37,41-44 con pronóstico más favorable, en comparación con aquellos casos asociados al cuidado de la salud, a pesar de un adecuado tratamiento antibiótico. 38 Lo anterior, puede ser debido el mayor inóculo directamente al torrente sanguíneo de los pacientes, cepas más virulentas, la inmunodeficiencia de los neonatos pretérmino y fuentes de infección no controladas en aquellos casos asociados al cuidado de la salud. 39 La forma probable de infección de este paciente fue durante el periparto, como único factor de riesgo prematuridad, no se logró aislamiento de P. agglomerans en cultivo de muestra rectovaginal en la madre.…”

Section: Discussionunclassified

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Sepsis temprana en un recién nacido pretérmino por Pantoea agglomerans: informe de caso y revisión de la literatura

2018

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Este artículo debe citarse comoGálvez-Cuitiva EA, Peralta-Palmezano JJ, LonngiRojas G. Sepsis temprana en un recién nacido pretérmino por Pantoea agglomerans: informe de caso y revisión de la literatura. Acta Pediatr Mex. 2018;39(1):52-59. Resumen INTRODUCCIÓN:Pantoea Agglomerans es un bacilo gramnegativo miembro de la familia Enterobacteriaceae, de distribución ubicua que, bajo ciertas circunstancias, puede tener un comportamiento patóge-no en el ser humano. Son pocos los casos de infección neonatal no asociados al cuidado de la salud descritos en la literatura; ninguno de ellos reportado en Colombia. PRESENTACIÓN DEL CASO: niña recién nacida, pretérmino, que desde su primer día presentó una inadecuada adaptación neonatal, con dificultad respiratoria, sepsis y un rápido deterioro clínico, lo cual requirió manejo y soporte en la unidad de cuidados intensivos neonatales. Se aisló por hemocultivos P. agglomerans, susceptible al manejo antibiótico instaurado, con una respuesta adecuada, así como una evolución clínica favorable. CONCLUSIÓN: la sepsis neonatal por P. agglomerans es poco frecuente, por lo que su desenlace dependerá de muchos factores: la detección temprana, la asistencia oportuna y el manejo adecuado que se brinde. PALABRAS CLAVE:Pantoea agglomerans, sepsis temprana, recién nacido, pretérmino. Early Sepsis in a Preterm Newborn by

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Sepsis temprana en un recién nacido pretérmino por Pantoea agglomerans: informe de caso y revisión de la literatura

2018

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“…P. agglomerans strains are among the most promising biocontrol agents for a variety of bacterial and fungal plant diseases, particularly fire blight of apple and pear. This species is currently listed as a Biosafety level 2 (BL2) organism due to clinical reports as an opportunistic human pathogen [2][3][4]. Septic arthritis or synovitis is usually common, clinical manifestation caused by P. agglomerans and often correlated with a predisposing factor i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Septic arthritis or synovitis is usually common, clinical manifestation caused by P. agglomerans and often correlated with a predisposing factor i.e. immunodeficiency (diabetes mellitus, malignancies, extremes of age) or use of central catheter [2][3][4][5]. This is first described case of septic arthritis following a road side injury in India.…”

Section: Introductionmentioning

confidence: 99%

MULTIDRUG RESISTANT Pantoea agglomerans IN A PATIENT WITH SEPTIC ARTHRITIS- A RARE REPORT FROM INDIA

Sharma¹,

BB²,

Misra³

et al. 2012

Int J of Micr Res

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Introduction-Pantoea agglomerans (P. agglomerans)is gram negative bacterium that belongs to the family Enterobacteriaceae. It is an opportunistic pathogen in the immunocompromised, causing wound infections, bacteremia, and urinary tract infections. This species is currently listed as a Biosafety level 2 (BL2) organism due to clinical reports as an opportunistic human pathogen. Septic arthritis or synovitis is usually common, clinical manifestations caused by P. agglomerans and often correlated with a predisposing factor i.e. immunodeficiency (diabetes mellitus, malignancies, extremes of age) or use of central catheter. This is first described case of septic arthritis following a road side injury. Case Report-In May 2012, A 40 year old male was admitted to the hospital with pain in left leg since last three months and swelling in his left knee for 4 days which was insidious in onset. On physical examination he was a febrile. His left knee was warm, swollen and tender. Three days later he became febrile and swelling gradually progressed resulting in cellulites. Ampicillin and Gentamicin were initiated/ started empirically. Later on an ill defined ulcer with irregular margin developed associated with purulent discharge. Patient was diagnosed as septic arthritis. Arthrocentesis was done and aspiration of synovial fluid was sent for culture and sensitivity to microbiology department and culture growth was phenotypically identified as P. agglomerans. The final identification of the bacteria by the Vitec 2 Systems (bioMerieux, France) was P. agglomerans. with multidrug resistant pattern in in-vitro testing .

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Toxicities Associated with Parenteral Nutrition

Aschner

Furlong

2009

General, Applied and Systems Toxicology

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Parenteral nutrition is a life‐sustaining therapy for patients with structural or functional intestinal diseases who are unable to tolerate sufficient enteral intake or absorb sufficient calories to support energy requirements. Despite its unquestionable value under these circumstances, prolonged dependence on parenteral nutrition is fraught with potentially life‐threatening complications related to the presence of unintended chemical and microbial contaminants of parenteral nutrition solutions, and insufficient knowledge of the optimal dosing of various parenteral nutrition additives thought to be essential to human nutrition. Infants and children with congenital or acquired gastrointestinal tract diseases who are dependent on parenteral nutrition to supply essential nutrients and calories for growth and development are particularly vulnerable. This chapter will review the potential toxicities associated with both unintended contaminants in parenteral nutrition, including microbes, phthalates, bisphenol‐A, particulates, lipid peroxidation products and aluminium, as well as intentional supplementation with potentially toxic substances, including trace metals, amino‐acid mixtures and lipid emulsions, when provided in excessive amounts or suboptimal ratios, or when normal metabolism or excretion are altered by an underlying medical condition. Practical applications and areas in need of further laboratory and human research are highlighted.

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An outbreak of Pantoea spp. in a neonatal intensive care unit secondary to contaminated parenteral nutrition

Cited by 83 publications

References 27 publications

Sepsis temprana en un recién nacido pretérmino por Pantoea agglomerans: informe de caso y revisión de la literatura

Sepsis temprana en un recién nacido pretérmino por Pantoea agglomerans: informe de caso y revisión de la literatura

MULTIDRUG RESISTANT Pantoea agglomerans IN A PATIENT WITH SEPTIC ARTHRITIS- A RARE REPORT FROM INDIA

Toxicities Associated with Parenteral Nutrition

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