A component of particulate matter (PM) air pollution that may provide one biologically plausible pathway for the observed PM air pollution-health effect associations is aerosol acidity (H+). An increasing number of observational studies have demonstrated associations between H' and increased adverse health effect in the United States and abroad. Although studies have shown significant H+ associations with increased morbidity in the United States, similar associations have yet to be shown with daily mortality. We considered a 2.5-year record of daily H+ and sulfate measurements (May 1988-October 1990 collected in the Buffalo, New York, region in a time-series analysis of respiratory, circulatory, and totl daily mortality and hospital admissions. Other copollutants considered induded particulate matter . 10 pm in aerodynamic diameter, coefficient of haze, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide. Various mding techniques were applied to control for confounding of efect estimates due to seaownality, weather, and day-ofweek effects. We found multiple significant pollutant-health effect associations-most strongly between SO-and respiratory hospital admissions (as indicated by its t-statistic). Additionally, H+ and SOQ42 demonstrated the most coherent associations with both respiratory hospital admissions [H+: relative risk (RR) = 1.31; 95% confidence intervl (CI), 1.14-1.51; and S042: RR = 1.18, CI, 1.09-1.28] and respiratory mortlity (H+: RR = 1.55, CI, 1.09-2.20; and SO42: RR 1.24, CI, 1.01-1.52). Thus, acidic sulfate aerosols represent a component of PM air pollution that may contribute to the previously noted adverse efcts of PM mass on human health, and the associations demonstrated in this study support the need for futher investigations into the potential health effects of acidic aerosols.