An Overview of Current Concepts Regarding the Pathogenesis and Pathophysiology of Hypertension

Manger, William M.; Page, I. H.

doi:10.1007/978-1-4612-5657-1_1

Cited by 8 publications

(4 citation statements)

References 235 publications

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“…In particular, hypertension is a worldwide problem of epidemic proportions, which presents in 15-20% of all adults. It is the most common serious chronic health problem because it carries a high risk of cardiovascular complications (3). In Japan, more than 20 million people suffer from hypertensive disease, 90% or more of whom suffer from essential hypertension (4).…”

Section: Introductionmentioning

confidence: 99%

Porcine Skeletal Muscle Troponin Is a Good Source of Peptides with Angiotensin-I Converting Enzyme Inhibitory Activity and Antihypertensive Effects in Spontaneously Hypertensive Rats

Katayama

Anggraeni

Mori

et al. 2007

J. Agric. Food Chem.

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In the search for novel peptides that inhibit the angiotensin I-converting enzyme (ACE), porcine skeletal troponin was hydrolyzed with pepsin, and the products were subjected to various types of chromatography to isolate active peptides. Glu-Lys-Glu-Arg-Glu-Arg-Gln (EKERERQ) and Lys-Arg-Gln-Lys-Tyr-Asp-Ile (KRQKYDI) were identified as active peptides, and their 50% inhibitory concentrations were found to be 552.5 and 26.2 microM, respectively. These are novel ACE inhibitory peptides, and the activity of KRQKYDI was the strongest among previously reported troponin-originated peptides. KRQKYDI was slowly hydrolyzed by treatment with ACE, and kinetic studies indicated that this peptide was a competitive inhibitor of the enzyme. When KRQKYDI was administered orally to spontaneously hypertensive rats (SHR) at a dose of 10 mg/kg, a temporary antihypertensive activity was observed at 3 and 6 h after administration.

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Section: Introductionmentioning

confidence: 99%

Porcine Skeletal Muscle Troponin Is a Good Source of Peptides with Angiotensin-I Converting Enzyme Inhibitory Activity and Antihypertensive Effects in Spontaneously Hypertensive Rats

Katayama

Anggraeni

Mori

et al. 2007

J. Agric. Food Chem.

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“…Hypertension is a worldwide problem of epidemic proportions, which presents in 15-20% of all adults. It is the most common serious chronic health problem because it carries with it a high risk of cardiovascular complication (1). As an insidious and ubiquitous disease, hypertension and its complications may contribute to the deaths of 1.5 million and the disability of another 1.5 million Americans each year (1).…”

Section: Introductionmentioning

confidence: 99%

“…It is the most common serious chronic health problem because it carries with it a high risk of cardiovascular complication (1). As an insidious and ubiquitous disease, hypertension and its complications may contribute to the deaths of 1.5 million and the disability of another 1.5 million Americans each year (1). Now, it is suggested that hypertension is closely related to food components, especially sodium chloride and protein intake, and the antihypertensive peptides may be associated with the presence of an antihypertensive peptide motif.…”

Section: Introductionmentioning

confidence: 99%

Hypotensive and Physiological Effect of Angiotensin Converting Enzyme Inhibitory Peptides Derived from Soy Protein on Spontaneously Hypertensive Rats

Wu¹,

Ding²

2000

J. Agric. Food Chem.

212

142

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Angiotensin converting enzyme (ACE) inhibitory peptides prepared from soy protein by the action of alcalase enzyme was tested for its hypotensive effect on spontaneously hypertensive rats (SHR). Captopril, an ACE inhibitor used widely for hypertension treatment, was also applied in comparison. A significant (p < 0.05) decrease in systolic blood pressure of SHR was observed when soy ACE inhibitory peptides were orally administrated at three different dose levels (100, 500, and 1000 mg/kg of body weight/day), whereas little change occurred in the blood pressure of normotensive rats even at the highest dose. After a month-long feeding, blood pressure readings of SHR fell by approximately 38 mmHg from the original level at the lowest dose; a steadily and progressively hypotensive effect existed for these soy ACE inhibitory peptides administration groups. An obvious fluctuation was observed at the third week, although Captopril had a stronger hypotensive effect. The ACE activity of serum, aorta and lung, and lipid content of serum of SHR upon administration of soy ACE inhibitory peptides did not show a significant difference from that of the control group, whereas the serum ACE activity increased and the aorta ACE activity decreased significantly (p < 0.05) for the Captopril group. Serum Na(+) concentration decreased significantly in both the peptides-treated groups and the Captopril-treated group in comparison with the control group, whereas no lowering effect was observed for serum K(+) and serum Ca(2+) concentrations. These results suggested that the hypotensive effect of ACE inhibitory peptides derived from soy protein could be at least partly attributed to the action on salt/water balance.

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“…15 Seseorang yang pindah ke daerah yang lebih modern, tidak teratur serta penuh tekanan, cenderung memiliki tekanan darah yang lebih tinggi. 16 Hipertensi di DKI Jakarta, diduga terkait dengan kondisi kota metropolitan yang semerawut dan penuh dengan ketegangan. 17 Tekanan sosial berhubungan dengan hipertensi yang tidak terkendali, pada perempuan lebih kuat (POR : 1,2) dibanding laki-laki (POR : 1,1).…”

Section: Pembahasanunclassified

Prevalensi dan Determinan Hipertensi di Pulau Jawa, Tahun 2004

Setiawan¹

2006

Kesmas: National Public Health Journal

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Hipertensi merupakan faktor risiko utama kardiovaskuler yang merupakan penyebab utama kematian di seluruh dunia. Peningkatan umur harapan hidup dan perubahan gaya hidup meningkatkan faktor risiko hipertensi di berbagai negara. Tujuan penelitian ini (1) Mengetahui prevalensi hipertensi dan penyebarannya di Pulau Jawa tahun 2004. (2) Mengetahui faktor-faktor sosiodemografi yang berhubungan dengan kejadian hipertensi. (3) Mengetahui kontribusi dan dampak potensial masing-masing faktor tersebut. Penelitian dengan rancangan studi Ekologi Multilevel ini menggabungkan variabel tingkat pengukuran individu dengan tingkat pengukuran ekologi dalam analisis bersama, dengan unit analisis individu. Analisis kontekstual dilakukan melalui kerangka konsep hipertensi, menggunakan metode analisis regresi logistik ganda, dengan status hipertensi sebagai variabel dependen. Data variabel dependen dan variabel perancu yang merupakan data pengukuran tingkat individu diambil dari data SKRT 2004. Data sosiodemografi tingkat pengukuran ekologi sebagai variabel independen utama, diperoleh dari Profil Kesehatan Indonesia, Statistik Indonesia, Statistik Kesehatan, Statistik Kesejahteraan Rakyat, danData Departemen Dalam Negeri, unit pengamatan provinsi. Hasil penelitian ini menunjukkan prevalensi hipertensi di Pulau Jawa 41,9%, dengan kisaran di masing-masing provinsi 36,6%-47,7%. Prevalensi di perkotaan 39,9% (37,0%-45,8%) dan di perdesaan 44,1% (36,2%-51,7%). Kata kunci: Hipertensi, faktor sosiodemografiAbstractHypertension is a main risk factor of cardiovascular disease which is ranked as number one cause of death in the world. The increase of life expectancy and changes in life style have increased the prevalence of hypertension risk factor in both developed and developing countries. The objectives of this study are (1) To know the prevalence and distribution of hypertension in di Java island, in year 2004. (2) To know sosiodemographic factors related to hypertension. (3) To know the contribution of each sosiodemographic factor toward hypertension. The study used multilevel ecologic study design that integrated both individual and ecological level variables measurement. The analysis method used in this study was contextual analysis and multiple logistic regression with hypertension status as dependent variable. The individual level measurement of variables such as hypertension status and age, job, education and sex is taken from Household Health Survey (SKRT) 2004. The sosiodemographic data which was ecological measurement level served as the main independent variables were taken from Indonesian Health Profile, Indonesian Health Statistics, Public Welfare Statistics and data from Department of Internal Affair, particularly from Province Surveillance Unit. The study results showed that the prevalence of hypertension in Java Island was 41.9%, with range of prevalence in provincial level of 36.6%-47.7%. The prevalence in urban areas was 39.9% (37.0%-45.8%) and in rural areas was 44.1% (36.2%-51.7%)Keywords: Hypertension, sosiodemographic factors

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An Overview of Current Concepts Regarding the Pathogenesis and Pathophysiology of Hypertension

Cited by 8 publications

References 235 publications

Porcine Skeletal Muscle Troponin Is a Good Source of Peptides with Angiotensin-I Converting Enzyme Inhibitory Activity and Antihypertensive Effects in Spontaneously Hypertensive Rats

Porcine Skeletal Muscle Troponin Is a Good Source of Peptides with Angiotensin-I Converting Enzyme Inhibitory Activity and Antihypertensive Effects in Spontaneously Hypertensive Rats

Hypotensive and Physiological Effect of Angiotensin Converting Enzyme Inhibitory Peptides Derived from Soy Protein on Spontaneously Hypertensive Rats

Prevalensi dan Determinan Hipertensi di Pulau Jawa, Tahun 2004

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