An overview of home tonometry and telemetry for intraocular pressure monitoring in humans

Yung, Edward; Trubnik, Valerie; Katz, L. Jay

doi:10.1007/s00417-014-2668-5

Cited by 17 publications

(17 citation statements)

References 58 publications

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“…The effect is known from current tonometry methods such as the iCare tonometer (Munkwitz et al, 2008), Tono-pen (Giaconi et al, 2016), or air-puff tonometers (Derka, 1980) that the sensitivity decreases at higher IOP levels (Yung et al, 2014;Giaconi et al, 2016;Eklund et al, 2000). This is explained by the fact that the possible deformation of the eye with a constant force decreases, which leads to a lower signal-to-noise ratio.…”

Section: Discussionmentioning

confidence: 99%

“…Although it is not considered a self-tonometer and generates higher deviations when it is not pointed directly on the vertex (Muttuvelu et al, 2012), it helps with the IOP measurement for children (Grigorian et al, 2015). Yung et al (2014) conclude that there is no approved technology for measuring diurnal IOP trends in a home environment to date.…”

Section: Introductionmentioning

confidence: 99%

“…It comprises malfunctions in the eye that lead to a subsequent loss of neuronal retinal cells (Yung et al, 2014;Giaconi et al, 2016;Grehn, 2012). There is no curative therapy available to date which makes early detection and avoiding further damage the most effective medical intervention (Giaconi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The Ocuton S, which is based on the measurement principle of the GAT following the concept of Draeger (1993), leads to a deviation of 6 mmHg from the mean of GAT reference measurements (Yung et al, 2014). Yet the contact-related disadvantages of the GAT exist for the Ocuton S as well.…”

Section: Introductionmentioning

confidence: 99%

“…Yet the contact-related disadvantages of the GAT exist for the Ocuton S as well. With the pressure phosphene tonometer, an unpowered spring applanation tonometer that indents the eye through the eyelid, no anesthetic is required, but measurements reach an absolute mean difference from the GAT reference of 6.6 mmHg (Yung et al, 2014). The Tiolat iCare measurement device evaluates the bounce-back of a small plastic stick that is shot onto the cornea, and is therefore considered to use a dynamic principle.…”

Section: Introductionmentioning

confidence: 99%

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The influence of intraocular pressure on the damping of a coupled speaker–air–eye system

Osmers¹,

Patzkó

Hoppe³

et al. 2018

J. Sens. Sens. Syst.

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Abstract. Although glaucoma is currently the world's most common cause of irreversible blindness, there is no curative therapy available to date. The major risk factor that can be influenced in order to stop disease progression is the eye pressure (IOP). Therefore early diagnosis of an altered IOP is essential for the goal of preserving vision. A novel IOP measurement principle for a handheld noncontact self-tonometer shall be validated.The measurement principle uses a pressure pulse generated by a loudspeaker to cause vibrations of the eye. In order to reach the required sound pressure, a closed pressure chamber is placed on the human orbit. With a microphone and a displacement sensor the dynamic behavior of the entire system is detected. In this article the abovementioned principle is being analyzed on porcine eyes under laboratory conditions.The combination of the loudspeaker, the pressure chamber, and the eye to be measured can be described as a coupled spring-mass-damper system. It is demonstrated for enucleated porcine eyes that a defined IOP variation leads to a change in the system's damping ratio. Considering only stochastic deviations, the derived standard uncertainty for the determination of the IOP amounts to < 1 mmHg in the physiological range.The in vitro measurements on porcine eyes help the understanding of the underlying physics and demand for further research on the influence of biometric parameters on eye vibrations. However, the laboratory results provide the basis for a gentle noncontact tonometry method with great applicational prospects. Data is currently being collected on human subjects in a clinical trial, to corroborate the measurement principle in vivo.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The influence of intraocular pressure on the damping of a coupled speaker–air–eye system

Osmers¹,

Patzkó

Hoppe³

et al. 2018

J. Sens. Sens. Syst.

View full text Add to dashboard Cite

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An Ultrasensitive Contact Lens Sensor Based On Self‐Assembly Graphene For Continuous Intraocular Pressure Monitoring

Liu

Wang

et al. 2021

Adv Funct Materials

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Elevated intraocular pressure (IOP) is the leading cause of glaucoma. As glaucoma is an irreversible neurological eye disease, it is urgent to realize timely and accurate IOP detection for diagnostic and therapeutic purposes. Here, a contact lens sensor for continuous IOP monitoring using self-assembly graphene (SAG), is developed. The combination of face-to-face water transfer printing and micro-electromechanical systems technology can realize the batch preparation of such a sensor. The sensor has good light transmittance and temperature stability. It exhibits an ultra-high IOP sensitivity of 1.0164 mV mm Hg −1 on a silicone eye, and 3.166 mV mm Hg −1 in vitro on the porcine eye with remarkable linearity. The sensitivity of the proposed sensor is high enough to be read by a commercial radio frequency identification read-write system for continuous wireless monitoring of IOP. Furthermore, the as-prepared sensor can work as normal for 24 h in phosphate buffer saline.

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Wearable and Implantable Intraocular Pressure Biosensors: Recent Progress and Future Prospects

Yang

Huang

et al. 2021

Advanced Science

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Biosensors worn on or implanted in eyes have been garnering substantial attention since being proven to be an effective means to acquire critical biomarkers for monitoring the states of ophthalmic disease, diabetes. Among these disorders, glaucoma, the second leading cause of blindness globally, usually results in irreversible blindness. Continuous intraocular pressure (IOP) monitoring is considered as an effective measure, which provides a comprehensive view of IOP changes that is beyond reach for the “snapshots” measurements by clinical tonometry. However, to satisfy the applications in ophthalmology, the development of IOP sensors are required to be prepared with biocompatible, miniature, transparent, wireless and battery‐free features, which are still challenging with many current fabrication processes. In this work, the recent advances in this field are reviewed by categorizing these devices into wearable and implantable IOP sensors. The materials and structures exploited for engineering these IOP devices are presented. Additionally, their working principle, performance, and the potential risk that materials and device architectures may pose to ocular tissue are discussed. This review should be valuable for preferable structure design, device fabrication, performance optimization, and reducing potential risk of these devices. It is significant for the development of future practical IOP sensors.

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An overview of home tonometry and telemetry for intraocular pressure monitoring in humans

Abstract: There is currently no technology that has been approved for use to allow for continuous monitoring of IOP fluctuations. New experimental technology being developed and currently undergoing clinical trials has demonstrated potential for changing the diagnosis and management of glaucoma.

Cited by 17 publications

References 58 publications

The influence of intraocular pressure on the damping of a coupled speaker–air–eye system

The influence of intraocular pressure on the damping of a coupled speaker–air–eye system

An Ultrasensitive Contact Lens Sensor Based On Self‐Assembly Graphene For Continuous Intraocular Pressure Monitoring

Wearable and Implantable Intraocular Pressure Biosensors: Recent Progress and Future Prospects

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