An overview of optical coherence tomography for ovarian tissue imaging and characterization

Wang, Tianheng; Brewer, Molly; Zhu, Quing

doi:10.1002/wnan.1306

Cited by 37 publications

(43 citation statements)

References 103 publications

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“…Recent progress in the design of Halbach arrays indicate the possibility of producing sizable field gradients in tissue at depths of 10 cm, at much greater strengths than that produced by dipolar magnets of comparable size [36, 37]. With regard to locating tumors, high-resolution imaging of vascularized tissues is already addressable by MR as well as by ultrasound [38], photoacoustic tomography [39], and optical coherence tomography [40]. …”

Section: Resultsmentioning

confidence: 99%

Polymer–iron oxide composite nanoparticles for EPR-independent drug delivery

et al. 2016

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Nanoparticle (NP)-based approaches to cancer drug delivery are challenged by the heterogeneity of the enhanced permeability and retention (EPR) effect in tumors and the premature attrition of payload from drug carriers during circulation. Here we show that such challenges can be overcome by a magnetophoretic approach to accelerate NP delivery to tumors. Payload-bearing poly(lactic-co-glycolic acid) NPs were converted into polymer–iron-oxide nanocomposites (PINCs) by attaching colloidal Fe3O4 onto the surface, via a simple surface modification method using dopamine polymerization. PINCs formed stable dispersions in serum-supplemented medium and responded quickly to magnetic field gradients above 1 kG/cm. Under the field gradients, PINCs were rapidly transported across physical barriers and into cells and captured under flow conditions similar to those encountered in postcapillary venules, increasing the local concentration by nearly three orders of magnitude. In vivo magnetophoretic delivery enabled PINCs to accumulate in poorly vascularized subcutaneous SKOV3 xenografts that did not support the EPR effect. In vivo magnetic resonance imaging, ex vivo fluorescence imaging, and tissue histology all confirmed that the uptake of PINCs was higher in tumors exposed to magnetic field gradients, relative to negative controls.

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Section: Resultsmentioning

confidence: 99%

Polymer–iron oxide composite nanoparticles for EPR-independent drug delivery

et al. 2016

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“…Although it has been demonstrated that OCT could be used for ovarian tissue characterization, we found that traditional OCT equipment had insufficient resolution for detailed visualization of ovarian tissue characteristics such as primordial follicles10111228. Recently, researchers reported the efficacy of OCT to detect cancer metastasis and to confirm follicle density27.…”

Section: Discussionmentioning

confidence: 89%

Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary

Takae

Tsukada

Sato

et al. 2017

Sci Rep

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Except for histological study, there are currently no suitable techniques available for the detection and identification of primordial follicles in ovary of primary ovarian insufficiency patients who have undetectable AMH levels. Also, the ability to locate and quantify follicles on ovarian cortex strips, without fixation, is valuable for patients who could undergo subsequent successful ovarian tissue transplantation. Although optical coherence tomography (OCT) is a well-established high resolution imaging technique without fixation commonly applied in biomedicine, few reports are available on ovarian tissue imaging. In present study, we established standard OCT follicle images at each developmental stage, including the primordial follicle, and demonstrated the efficacy of OCT to estimate IVF outcome in transplanted mice ovary like ovarian reserve tests. Unfortunately, the current commercial OCT could not be used to accurate follicle count the number of follicles for whole ovary, because the maximum depth of examination was 100 μm. And we demonstrated the safety of OCT examination, it did not affect IVF outcome and birth defect rate, and reproductive ability. Although there is room for improvement, these findings will be first step to bring OCT examination a step closer to clinical application for measuring true ovarian reserve and localizing follicles.

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“…An overview of employment of OCT for characterization of ovarian tissue was given in a review paper. 55 Recent animal studies aimed at proving the efficacy of OCT in ovary transplantation 56,57 demonstrated high potential of OCT in detecting metastases in the ovary, including micrometastases. 56 A recent ex vivo study employing full-field OCT 58,59 demonstrated that application of standard image characterization (calculation of mean, variance, skewness, kurtosis, and entropy) to OCT images of ovaries allowed to differentiate normal ovary from a malignant one with a sensitivity of 92% and specificity of 88%.…”

Section: Optical Coherence Tomography Diagnostics Of Ovarymentioning

confidence: 99%

Optical coherence tomography in gynecology: a narrative review

2017

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Abstract. Modern gynecologic practice requires noninvasive diagnostics techniques capable of detecting morphological and functional alterations in tissues of female reproductive organs. Optical coherence tomography (OCT) is a promising tool for providing imaging of biotissues with high resolution at depths up to 2 mm. Design of the customized probes provides wide opportunities for OCT use in gynecology. This paper contains a retrospective insight into the history of OCT employment in gynecology, an overview of the existing gynecologic OCT probes, including those for combination with other diagnostic modalities, and state-of-the-art application of OCT for diagnostics of tumor and nontumor pathologies of female genitalia. Perspectives of OCT both in diagnostics and treatment planning and monitoring in gynecology are overviewed. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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An overview of optical coherence tomography for ovarian tissue imaging and characterization

Cited by 37 publications

References 103 publications

Polymer–iron oxide composite nanoparticles for EPR-independent drug delivery

Polymer–iron oxide composite nanoparticles for EPR-independent drug delivery

Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary

Optical coherence tomography in gynecology: a narrative review

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