An Overview of the Chemistry and Pharmacological Potentials of Furanones Skeletons

Abstract

The furanone structure, a significant group of heterocyclic compounds, is frequently found in natural products that are exhibiting striking pharmacological effects and a growing field of research. They have a wide spectrum of pharmaceutical activity: anticataract, anticancer, antibacterial, anti-inflammatory, anticonvulsant. This review article presents a summary of natural furanones, synthetic methods, and the biological effects of these important compounds. Solid-phase method, cross-coupling reactions, Maillard-type reaction, the cycloaddition of alcohol and phenyl nitrile oxide, and side-chain modifications are some types of reactions for the preparation of furanone derivatives. Methods of preparation and pharmacological activities of furanone skeletons that are discussed in this review article will help the medicinal chemists to design and execute novel procedures towards finding new drugs.

Recyclable Catalysts for Alkyne Functionalization

“…Many furanone-containing compounds are known to show interesting biological activities [24] such as antibacterial, cytotoxic, antimicrobial, antibiotic, and antitumor activities. Prior work has shown the need for expensive transition metal catalysts for each transformation desired, posing potential drawbacks for the synthesis of these functionalized alkylidenefuranones [25].…”

Anticancer and Apoptotic Activity in Cervical Adenocarcinoma HeLa Using Crude Extract of Ganoderma applanatum

“…These days, the synthesis of furanone derivatives and the exploration of their medicinal effects have been some of the main concerns of researchers [35]. Furanone is divided into three categories: 2(3H)-furanone, 2(5H)-furanone, and 3(2H)-furanone [36]. 2(5H)-furanone (Figure 8) units are widely present in many natural products as structural components and skeletons [37].…”

Pyridine-catalyzed ring-opening reaction of cyclopropenone with bromomethyl carbonyl compounds toward furan-2(5H)-ones

“…Furan-2(5 H )-ones, 1 also known as γ-butenolides, are ubiquitous in natural products 2 and medicinal compounds. 3 Moreover, they have also been used as synthons and intermediates in organic synthesis. 4 Thus, the development of a facile synthetic pathway toward such frameworks remains a desired goal for organic chemists.…”