No abstract

No abstract

No abstract

The furanone structure, a significant group of heterocyclic compounds, is frequently found in natural products that are exhibiting striking pharmacological effects and a growing field of research. They have a wide spectrum of pharmaceutical activity: anticataract, anticancer, antibacterial, anti-inflammatory, anticonvulsant. This review article presents a summary of natural furanones, synthetic methods, and the biological effects of these important compounds. Solid-phase method, cross-coupling reactions, Maillard-type reaction, the cycloaddition of alcohol and phenyl nitrile oxide, and side-chain modifications are some types of reactions for the preparation of furanone derivatives. Methods of preparation and pharmacological activities of furanone skeletons that are discussed in this review article will help the medicinal chemists to design and execute novel procedures towards finding new drugs.

In this study, a novel magnetic MCM-41-type mesoporous silica-supported Fe/Cu (Fe3O4@Fe–Cu/MCM-41) was prepared, characterized, and used as a heterogeneous catalyst for the synthesis of symmetric biaryls by Ullmann cross-coupling reaction. This nanocomposite was characterized using Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and nitrogen adsorption–desorption isotherm. The Fe3O4@Fe–Cu/MCM-41 was applied as an efficient catalyst in the synthesis of biaryls under optimum conditions. This nanocatalyst was recovered and reused several times without significant loss of activity.