An overview on Hypericum species of Turkey

Eroğlu, Engin; Aksu, B.; Mat, Afife

doi:10.5897/jpp2013.0260

Cited by 20 publications

(6 citation statements)

References 42 publications

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“…These compounds were previously reported in other members of Hypericaceae family. A sample from a representative of the same family, the well-known H. perforatum (St. John’s wort) [1], was also included in HPTLC analysis to offer a reliable comparison agent for the studied plant. HPTLC results are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Hypericum capitatum Choisy is part of the Hypericum genus, Hypericaceae family, and it is widely spread in temperate regions. H. capitatum is characterized by the presence of translucent secretory canals or cavities that contain plant biomarkers [1]. These plants have been widely used over the present territory of Turkey starting from antiquity, as treatments for various diseases.…”

Section: Introductionmentioning

confidence: 99%

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Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats

Fărcăş

Moţ

Zagrean-Tuza

et al. 2019

BMC Complement Altern Med

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BackgroundNatural extracts with beneficial biological activities are nowadays of high interest, in various treatment or prophylaxis. Hypericum capitatum has been known for its curative effects for centuries and its extracts have become of interest due to their distinct activity among other Hypericaceae members. In this study, further light is aimed to be shed on the secondary-metabolites composition of H. capitatum extracts, using chromatographic techniques and Electron paramagnetic resonance profiles in alkaline medium. Considering that no previous works explored the anti-inflammatory activity of H. capitatum, here, an in vivo study is also designed in order to evaluate this property by assessing the impact of one of H. capitatum extracts in ameliorating turpentine oil-induced inflammation on rats and to quantify their blood antioxidants level.MethodsChromatographic techniques and Electron paramagnetic resonance spectroscopy were used in order to describe the chemical profile in different parts of the plant. The in vivo study on turpentine-oil induced inflammation in rats included three doses of H. capitatum extract expressed in rutin concentration. Oxidative stress was measured using total oxidative status, total antioxidant capacity, oxidative stress index, 3-nitrotyrosine, nitric oxide, malondialdehyde, superoxide dismutase, catalase and the inflammatory response was evaluated by performing a complete blood cells count and C reactive protein.ResultsThe extract was remarkably rich in rutin; however, other polyphenolic-like minor components appeared important in explaining the observed biological properties. The tested extract prevents the increase of inflammation-induced white blood cell count, number of neutrophils, and serum nitric oxide, and did so in a dose-dependent manner, similarly to the positive control—diclofenac. In addition, the same extract appeared to be a good alternative to diclofenac to restore total oxidative status, thiobarbituric active reactive species, total proteins and C reactive proteins. Moreover, antioxidant enzymes such as catalase, superoxide dismutase and total serum thiol concentration were significantly increased by the tested extract.ConclusionsDue to its powerful reservoir rich in rutin, H. capitatum extract depicted its in vivo antioxidant and anti-inflammatory effects indicating it to be a good alternative to conventional drugs for oxidative stress protection.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats

Fărcăş

Moţ

Zagrean-Tuza

et al. 2019

BMC Complement Altern Med

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“…Hypericum perforatum L. is accepted as a valuable medicinal plant in Turkey as well as all over the world and is widely used as an alternative in the treatment of wounds and burns (Özkan & Mat 2013). There are many active substances in the composition of the H. perforatum L. plant that have different and complex structures and show different pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Essential Oils of Medicinal Plants Grown in the Thrace Region in Türkiye, Hypericum perforatum L.

Güler,

Ozdemir

2023

Pharmacognosy Magazine

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Background There are many active substances in the composition of the Hypericum perforatum L. plant that have different and complex structures and show different pharmacological effects. It was accepted as a medicinal plant by the World Health Organization in 2002, and it is given a detailed place in the monographs under the name Hyperici herba. In these monographs, the antibacterial, antiviral, antidepressant, protein kinase-C inhibitor, and wound-healing effects of the plant were described. Objectives The aim of this study is to determine the essential oil components in the samples of the H. perforatum L. plant, which is widely grown in the Thrace region in Türkiye. Materials and Methods H. perforatum L. plant growing naturally in the provinces of the Thrace region was collected, and the essential oils of the plant were obtained by using the hydro distillation method after the collected herbs were dried. Chemical content analyses were performed on a gas chromatography-flame ionization detection (GC-FID). Results The main components of the essential oil of the plant are sesquiterpenes (ß-caryophyllene, caryophyllene oxide, β-selinene, α-selinene, β-farnesene, α-amorphene, spathulenol), alcohols (1-tetradecanol, 1-tridecanol, phytol, and alpha cadinol), and fatty acids (pentadecanoic acid, palmitic acid, and 9, 12 octadecadienoic acid). Conclusion This is the first study to determine the chemical composition of essential oil in H. perforatum L. samples collected from the Thrace region in Türkiye. The essential oil content of the plant can be affected by factors such as the developmental stages of the plant (preblooming, flowering stage, and fruiting time), use of fresh or dry plant material, extraction method, genetic parameters, and climate.

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“…Secondary metabolites from Hypericum species have been classified into at least 11 different kinds, including naphrodiantrons, flurogonol derivatives, flavonoids, organic acids, essential oils, amino acids, xanthones, tannins, proxyanidins, and other water-soluble components. Because of its antispasmodic, antiseptic, anti-depressive, and therapeutic properties for skin conditions like wounds and burns, it is one of the frequently employed genus in pharmacological research [2,5,6]. Results from recent studies have shown that hyperforin is the main chemical responsible for the antidepressant effects of Hypericum extracts [7].…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that H. orientale extract shows acetylcholinesterase and butyrylcholinesterase inhibitory activity with IC50 values of 165.20 ±0.62 and 50.57 ± 0.32 µg/mL, respectively [14]. Although many studies on the phytochemistry, biological activity, and essential oil composition of Hypericum species have been conducted [6,[15][16][17][18][19][20], there is still limited research on H. adenotrichum. However, the knowledge of the essential oil compositions of the H. adenotrichum species is limited [21].…”

Section: Introductionmentioning

confidence: 99%

Chemical Profiling and Antimicrobial Activity of Essential Oils from Hypericum adenotrichum Spach. An Endemic Species

Saltan¹,

Köse²,

Kırcı³

et al. 2023

jrp

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The purpose of this study was to determine the content of essential oils isolated from the herba and roots of Hypericum adenotrichum Spach., an endemic, wild-growing species of Turkish flora. Gas Chromatography-Mass Spectroscopy (GC-MS) and Gas Chromatography-Flame Ionization Detector (GC-FID) were used to examine the essential oils (EO). In the essential oils of the root of H. adenotrichum, the compounds were found, with undecane (64.4%), hexadecanoic acid (5.3%), and α -copaene (3.9%) as the primary components. Three significant herba compounds, germacrene D (13.3%), hexadecanoic acid (11.3%), and cadinene (6%) were found. Moreover, in this study antimicrobial effects of EO of endemic H. adenotrichum against Escherichia coli NRRL B-3008, Staphylococcus aureus ATCC 6538, Salmonella tymphirium ATCC 14028, Staphylococcus aureus ATCC 700699, Candida albicans ATCC 90028 and Candida krusei ATTC 6258. H. adenotrichum root and herba extracts were made, and LC-MS/MS analysis was used to determine the primary constituents of the extracts. The chemicals found in the herb and root, respectively, include 3-caffeoylquinic acid, 5-caffeoylquinic acid, quercetin hexoside, quinic acid, quercetin, and catechine.

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An overview on Hypericum species of Turkey

Cited by 20 publications

References 42 publications

Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats

Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats

Chemical Composition of Essential Oils of Medicinal Plants Grown in the Thrace Region in Türkiye, Hypericum perforatum L.

Chemical Profiling and Antimicrobial Activity of Essential Oils from Hypericum adenotrichum Spach. An Endemic Species

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