An oxygen-carrying and lysosome-targeting BODIPY derivative for NIR bioimaging and enhanced multimodal therapy against hypoxic tumors

Pentafluorobenzene: Promising Applications in Diagnostics and Therapeutics

“…The oxygen-carrying capability of the PFB unit in 53 contributes to relieving tumor hypoxia. The authors have evaluated the chemo-phototherapeutic ability of 53 in mice models and mice organs (Figure b) . As discussed in Introduction, PFB-functionalized organic, polymeric, and gold nanoparticles can be useful in the field of therapeutics and diagnostics.…”

“…(Right) Ex vivo imaging of tumor and major organs harvested from euthanized mice bearing 4T1 tumor at 12 h after injection of FBD-M (refer to the web version of this article to view the legend color). Reproduced from ref with permission from Elsevier.…”

“…The authors have evaluated the chemo-phototherapeutic ability of 53 in mice models and mice organs (Figure 17b). 92 As discussed in Introduction, PFB-functionalized organic, polymeric, and gold nanoparticles can be useful in the field of therapeutics and diagnostics. In 2019, Wu and co-workers developed an organic small molecular nanoparticle based on the self-assembly of amphiphilic fluoroporphyrins 54 and 55 for PDT and PTT therapy.…”

Near-infrared BODIPY photosensitizers for two-photon excited singlet oxygen generation and tumor cell photodynamic therapy

“…The near-infrared absorption region is considered an ideal window for photodynamic therapy. [13][14][15][16] In the NIR region, the light penetration is stronger and the photobleaching is lower, causing minimal damage to healthy tissues. The use of nearinfrared light to excite the photosensitizers can effectively avoid the interference of spontaneous background fluorescence of biological tissues, which is conducive to improving the effect of photodynamic therapy.…”

“…Structural modification of the BODIPY core can red-shift the absorption wavelength of BODIPY to the near-infrared region. [17][18][19][20] At the same time, by combining the BODIPY photosensitizer with molecular moieties targeting lysosomes, highly selective recognition of tumor cell lysosomes can be achieved. [21][22][23][24][25] A similar organelle targeting strategy not only enhances the accumulation of photosensitizers in tumor cells, but also reduces the damage to normal cells, improving the efficacy and safety of photodynamic therapy.…”