An Ultra-Sensitive Electrochemical Sensor for the Detection of Carcinogen Oxidative Stress 4-Nitroquinoline N-Oxide in Biologic Matrices Based on Hierarchical Spinel Structured NiCo2O4 and NiCo2S4; A Comparative Study

Abstract

Various factors leads to cancer; among them oxidative damage is believed to play an important role. Moreover, it is important to identify a method to detect the oxidative damage. Recently, electrochemical sensors have been considered as the one of the most important techniques to detect DNA damage, owing to its rapid detection. However, electrode materials play an important role in the properties of electrochemical sensor. Currently, researchers have aimed to develop novel electrode materials for low-level detection of biomarkers. Herein, we report the facile hydrothermal synthesis of NiCo2O4 micro flowers (MFs) and NiCo2S4 micro spheres (Ms) and evaluate their electrochemical properties for the detection of carcinogen-causing biomarker 4-nitroquinoline n-oxide (4-NQO) in human blood serum and saliva samples. Moreover, as-prepared composites were fabricated on a glass carbon electrode (GCE), and its electrochemical activities for the determination of 4-NQO were investigated by using various electrochemical techniques. Fascinatingly, the NiCo2S4-Ms showed a very low detection limit of 2.29 nM and a wider range of 0.005 to 596.64 µM for detecting 4-NQO. Finally, the practical applicability of NiCo2S4-Ms in the 4-NQO spiked human blood serum and saliva samples were also investigated.

Alkaline Phosphatase Immobilized CdTe/ZnS Quantum Dots for Dual-Purpose Fluorescent and Electrochemical Detection of Methyl Paraoxon

“…The cyclic voltammograms were measured using GCE modified CdTe/ZnS QDs at different scan rates from 10 to 120 mV/s, which gives the similar structure of oxidation/reduction wave and redox peak current increases with increasing the scan rate (Figure c). Figure d shows the good linear relationship between square root of scan rates with the peak current of GCE modified CdTe/ZnS QDs …”

“…Figure 7d shows the good linear relationship between square root of scan rates with the peak current of GCE modified CdTe/ZnS QDs. 50 The electrochemical behaviors of bare GCE and CdTe/ZnS QDs/GCE have been successfully authenticated (Figure 7) for the development of an electrochemical approach for the detection of methyl paraoxon. The cyclic voltammetry was investigated using GCE modified with CdTe/ZnS QDs in the presence of alkaline phosphatase and methyl paraoxon.…”

The Physical Chemistry and Chemical Physics (PCCP) Section of the International Journal of Molecular Sciences in Its Publications: The First 300 Thematic Articles in the First 3 Years

“…The third of the directions officially accepted in the PCCP Section, is represented by only 11 articles [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ], including 9 Originals and 2 Reviews. Their distribution by years of publication is presented in Table 4 .…”

Nickel Cobaltite Nanoplate‐Based Electrochemical Sensing Platform from Printable Inks for Simultaneous Detection of Dopamine and Uric Acid

“…[18] NiCo 2 O 4 is an example of spinel used in the literature as a composite and hybrid material for biosensing applications. NiCo 2 O 4 based nanocomposite has been used to detect biomolecules such as glucose, [19] trypsin, [20] pyridoxine, [21] 4nitroquinoline N-oxide, [22] and urea. [23] The use of NiCo 2 O 4 as an electrocatalyst for biosensing is limited due to the high resistance offered by the amorphous nanostructures and the use of binders/additives while fabricating the electrodes.…”