Nickel Cobaltite Nanoplate‐Based Electrochemical Sensing Platform from Printable Inks for Simultaneous Detection of Dopamine and Uric Acid

Abstract

2D metal oxide-based nanomaterials have emerged as an exciting area of research owing to their rich electrochemical properties and diverse applications, including biosensors. In this work, we have synthesized ultra-thin Co 3 O 4 , NiO, and NiCo 2 O 4 nanostructures supported on a carbon cloth and printed graphite/Kapton substrates following thermal reduction of self-assembled metal alkanethiolates. These nanostructures act as a sensing platform for simultaneous detection of dopamine (DA) and uric acid (UA), important biological molecules in physiological and pathological tests. The ultrathin 2D nanoplates of NiCo 2 O 4 spinel formed in this study exhibit high electrochemical activity than pristine NiO and Co 3 O 4 . The electrochemical character-ization studies indicate that NiCo 2 O 4 possesses a high potential for DA and UA with a peak separation of ~140 mV, high sensitivity, and excellent selectivity. The low-cost and disposable, single-shot probe biosensors fabricated in this work possess a wide working range of 0.001-1000 μM with detection limits of 0.33 and 0.49 nM for DA and UA, respectively, with a practically achievable limit of quantification of ~1 nM. Multiple sensing electrodes are printed on graphite/Kapton all at once following this method with improved reproducibility for DA and UA sensing further extending the scope of work towards mass fabrication and practical usage.

SiC/Graphene Film by Laser CVD as an Implantable Sensor Material for Dopamine Detection

“…As noted in Table , the nanoforest-like film electrode exhibited a relatively lower detection limit and wider linear range toward DA detection, which was comparable to those of the current Si-based biosensors by the CVD method. The modified electrodes exhibited low LOD but poor long-term stability because of weak interfacial adhesion. , Meanwhile, the non-silicon substrate used makes it difficult to construct miniature sensors via the current semiconductor processing technology. , Future investigations are needed to focus on improving the electrochemical performance of the film to reduce the detection limit to the nM level.…”

“…37,52 Meanwhile, the non-silicon substrate used makes it difficult to construct miniature sensors via the current semiconductor processing technology. 39,53 Future investigations are needed to focus on improving the electrochemical performance of the film to reduce the detection limit to the nM level.…”

2D materials: increscent quantum flatland with immense potential for applications

“…[ 84 ] ( g ) Cyclic Voltammogram of Ni-C4SH/Au mesh as working electrodes in the glucose of different concentrations at a scan rate of 50 mV s − 1 Figure adapted from ref [ 85 ] ( h ) LSV curves at 5 mV/s of Ni-Co oxide nanoplate Figure adapted from ref. [ 86 ] ( i ) Simultaneous measurements with increasing concentration of equimolar Dopamine and Uric Acid from 1 nM to 1000 μM, respectively (Figure adapted from ref [ 87 ]) …”

Engineering FeOOH/Fe2O3@Carbon Interfaces With Biomass‐Derived Carbon Nanodot/Iron Colloids for Efficient Redox‐Modulated Dopamine Voltammetric Detection

“…Dopamine (DA) performs critical regulatory functions in various mammalian physiological systems, including the central nervous, renal, cardiovascular, and hormonal systems [1–3] . Dysregulation of DA has been linked with several severe degenerative diseases, including Parkinson's disease, Alzheimer's disease, schizophrenia, ADHD, and HIV infection [4–7] . Accurate quantification of DA in biological fluids is pivotal for the diagnosis and treatment of these ailments, given its typically low concentration range (normal range: 0.01‐1.0 μM), [5,8–10] it is necessitating the development of highly sensitive and selective analytical tools.…”