An ultrasensitive split-type electrochemical immunosensor based on controlled-release strategy for detection of CA19-9

Li, Bing; Li, Yunxiao; Li, Chenchen; Yang, Jinghui; Liu, De-Ling; Wang, Huabin; Xu, Rui; Zhang, Yihe; Wei, Qin

doi:10.1016/j.bios.2023.115180

Cited by 24 publications

(13 citation statements)

References 37 publications

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“…This antigen was first identified in pancreatic and colon cancer patient’s serum in 1981. It is a Lewis antigen of the MUC1 glycoprotein [ 8 , 121 ]. CA 19-9 normal level in serum is less than 37 U/mL.…”

Section: Cancer Biomarkersmentioning

confidence: 99%

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

et al. 2023

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Cancer is one of the major public health issues in the world. It has become the second leading cause of death, with approximately 75% of cancer deaths transpiring in low- or middle-income countries. It causes a heavy global economic cost estimated at more than a trillion dollars per year. The most common cancers are breast, colon, rectum, prostate, and lung cancers. Many of these cancers can be treated effectively and cured if detected at the primary stage. Nowadays, around 50% of cancers are detected at late stages, leading to serious health complications and death. Early diagnosis of cancer diseases substantially increases the efficient treatment and high chances of survival. Biosensors are one of the potential screening methodologies useful in the early screening of cancer biomarkers. This review summarizes the recent findings about novel cancer biomarkers and their advantages over traditional biomarkers, and novel biosensing and diagnostic methods for them; thus, this review may be helpful in the early recognition and monitoring of treatment response of various human cancers.

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Section: Cancer Biomarkersmentioning

confidence: 99%

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

et al. 2023

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“…Nanoarrays possess excellent conductivity and a large specific surface area, which can avoid the problem of blocking active sites caused by traditional adhesives. [28][29][30] Then, PANI is coated on the surface of NiFeP nanosheet arrays by a simple electrochemical polymerization method to obtain polyaniline functionalized NiFeP nanocomposites with good biocompatibility, for use as the substrate material for the sandwich-type electrochemical immunosensor to detect SARS-CoV-2 NP for the first time. In addition, Au nanoparticles decorated Cu 2 O nanocubes (namely Au/Cu 2 O) are synthesized as a signal amplification probe of the immunosensor.…”

Section: Introductionmentioning

confidence: 99%

A polyaniline functionalized NiFeP nanosheet array-based electrochemical immunosensor using Au/Cu₂O nanocubes as a signal amplifier for the detection of SARS-CoV-2 nucleocapsid protein

Bai

Shi

Zhang

et al. 2023

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“…Mesoporous silica nanomaterials (MSNMs) are porous materials that are widely used in the field of biosensing because of their stable physical and chemical properties and large specific surface area. , A common strategy for constructing MSNM-based ECL sensors is to employ MSNMs as porous carriers to wrap ECL emitters and use biological materials, such as aptamers (Apts) and antibodies, for hole sealing such that only specific target molecules can recognize them, triggering the inhibition or release of ECL emitters, which is recorded as the signal output changes. , Hong et al loaded tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy) 3 2+ ) into spherical MSNMs and attached the troponin I (TnI) antibody to their surface for the specific recognition of TnI . When Ru(bpy) 3 2+ was loaded inside the MSNMs and reacted with tripropylamine in the electrolyte, a strong ECL signal was observed.…”

Section: Introductionmentioning

confidence: 99%

“…Mesoporous silica nanomaterials (MSNMs) are porous materials that are widely used in the field of biosensing because of their stable physical and chemical properties and large specific surface area. 19,20 ) into spherical MSNMs and attached the troponin I (TnI) antibody to their surface for the specific recognition of TnI. 22 When Ru(bpy) 3…”

Section: Introductionmentioning

confidence: 99%

Screening-Capture-Integrated Electrochemiluminescent Aptasensor Based on Mesoporous Silica Nanochannels for the Ultrasensitive Detection of Deoxynivalenol in Wheat

Wang

Wei

et al. 2023

J. Agric. Food Chem.

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To prevent the contamination of cereals by mycotoxins, establishing a sensitive and rapid method for the detection of mycotoxins is essential. In this study, a screening-capture-integrated electrochemiluminescence (ECL) aptasensor based on mesoporous silica films (MSFs) was successfully prepared for the ultrasensitive and highly selective detection of deoxynivalenol (DON) in wheat. The narrow nanochannels of MSFs can realize size screening, thereby eliminating the influence of macromolecular substances and providing a pure environment for the signal probe (tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy) 3 2+ )) to reach the indium tin oxide (ITO) conductive substrate, which significantly improves the anti-interference ability of the screening-captureintegrated ECL sensor. The aptamer (Apt) attached to the surface of the MSFs can specifically capture DON, and the resulting DON-Apt complex has a gated effect on the MSFs, triggering the inhibition of Ru(bpy) 3 2+ in the electrolyte from reaching the ITO surface. Therefore, the ECL intensity of the sensor decreased with increasing DON concentration to achieve a quantitative detection of DON. Under optimized conditions, the linear range of the screening-capture-integrated ECL aptasensor was 0.001−200 μg/kg, and the detection limit was as low as 5.27 × 10 −5 μg/kg (S/N = 3). In conclusion, this study developed a screening-captureintegrated ECL aptasensor that combines size screening and specific capture for the detection of DON in wheat, providing a new approach for the early detection of wheat mildew.

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An ultrasensitive split-type electrochemical immunosensor based on controlled-release strategy for detection of CA19-9

Cited by 24 publications

References 37 publications

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

A polyaniline functionalized NiFeP nanosheet array-based electrochemical immunosensor using Au/Cu₂O nanocubes as a signal amplifier for the detection of SARS-CoV-2 nucleocapsid protein

Screening-Capture-Integrated Electrochemiluminescent Aptasensor Based on Mesoporous Silica Nanochannels for the Ultrasensitive Detection of Deoxynivalenol in Wheat

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An ultrasensitive split-type electrochemical immunosensor based on controlled-release strategy for detection of CA19-9

Cited by 24 publications

References 37 publications

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

A polyaniline functionalized NiFeP nanosheet array-based electrochemical immunosensor using Au/Cu2O nanocubes as a signal amplifier for the detection of SARS-CoV-2 nucleocapsid protein

Screening-Capture-Integrated Electrochemiluminescent Aptasensor Based on Mesoporous Silica Nanochannels for the Ultrasensitive Detection of Deoxynivalenol in Wheat

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A polyaniline functionalized NiFeP nanosheet array-based electrochemical immunosensor using Au/Cu₂O nanocubes as a signal amplifier for the detection of SARS-CoV-2 nucleocapsid protein