An unusual glucoside from Cleistanthus gracilis

Pinho, Paulo; Naengchomnong, Waree; Kijjoa, Anake; Nazareth, Naïr; Silva, Artur M. S.; Eaton, G. R.; Herz, Werner

doi:10.1016/j.phytochem.2006.01.014

Cited by 10 publications

(10 citation statements)

References 12 publications

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“…Thereafter the extracts were concentrated in a rotatory evaporator at 40 °C to dryness. The crude extracts were fractionated based on the partition method of Charaux-Paris using solvents with increasing polarities (Pinho et al, 2006;Silva et al, 2012). Thus, to 1 g of crude extract 50 mL of n-hexane was added and centrifuged at 5500 g, 20 min, 4 °C.…”

Section: Preparation Of Heather Extracts and Fractionationmentioning

confidence: 99%

Antioxidant and antimicrobial activity and potential of heather (Erica spp.) extracts in the control of Listeria monocytogenes

Santos

Luís

Ferreira

et al. 2018

Int J of Food Sci Tech

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Summary In this work, heather and its flowers were studied regarding their antioxidant and antimicrobial activities. Plants were subjected to ultrasound‐assisted methanolic extraction followed by fractionation. A phytochemical characterisation of extracts content in total phenols and flavonoids, and their antioxidant activity was performed. The antimicrobial activity was evaluated through the determination of minimum inhibitory concentration and by bioautography. Following, studies on the antilisterial potential were carried out by: time‐kill curves, inhibition of biofilm formation and tolerance of Listeria monocytogenes to adverse conditions. The results evidenced the antioxidant activity in both extracts, as well as, the antimicrobial activity against Gram‐positive bacteria. Concerning the evaluation of the antilisterial potential, a bacteriostatic behaviour and inhibition of biofilms formation ability were observed. Listeria monocytogenes showed an increased susceptibility to adverse conditions when preincubated with extracts. Thus, heather and its flowers may be a source of new compounds with antilisterial activity potential.

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Section: Preparation Of Heather Extracts and Fractionationmentioning

confidence: 99%

Antioxidant and antimicrobial activity and potential of heather (Erica spp.) extracts in the control of Listeria monocytogenes

Santos

Luís

Ferreira

et al. 2018

Int J of Food Sci Tech

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“…The crude methanolic extracts were fractionated using the Charaux-Paris method, which consists in a sequential liquid-liquid partition with n-hexane (Fraction 1), diethyl ether (Fraction 2) and water (Fraction 3) ( Figure 3) [41,42]. This process allows obtaining fractions with different and increasing polarities.…”

Section: Extraction and Fractionationmentioning

confidence: 99%

Julbernardia paniculata and Pterocarpus angolensis: From Ethnobotanical Surveys to Phytochemical Characterization and Bioactivities Evaluation

et al. 2020

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Julbernardia paniculata and Pterocarpus angolensis are two plant species with important application in African traditional medicine, particularly in Angola, in the treatment of several diseases. However, scientific studies concerning these species are scarce. The goal of this work was to know better which medicinal approaches are used by the Huíla population in Angola by means of ethnobotanical surveys. Furthermore, extracts of both plants were phytochemically characterized. Antioxidant, anti-inflammatory, wound-healing activities, and potential cytotoxicity were also studied. With this study it was possible to verify that 67% of the individuals that use medicinal plants are women, and their main therapeutic uses are the treatment of problems of the digestive system and skin disorders. Barks of J. paniculata and leaves of P. angolensis are the most often used plant parts. Through high-performance liquid chromatography coupled to diode-array detector (HPLC-DAD) and GC-MS it was possible to characterize the chemical composition of the two species, which are rich in phenolic compounds, terpenes, terpenoids, sesquiterpenoids and fatty acids. Both plants showed to possess antioxidant, anti-inflammatory proprieties, and wound-healing activity. To the best of our knowledge, this is the most comprehensive study of these two species and the first ethnobotanical and ethnopharmacological study of medicinal plants from this region of Angola.

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“…4). Lupeol (21) and 3-oxofriedelin (22) were isolated from the stem and roots of C. gracilis (Pinho et al 2006).…”

Section: Triterpenesmentioning

confidence: 99%

“…Recently, gracicleistanthoside (28) has been isolated from the stem and roots of C. gracilis Hook. f., collected from Thailand (Pinho et al 2006). Figure 6 shows the structure of ellagic acid (27) Acetylation of gracicleistanthoside (28) gave rise to the acetate 29 whose structure was established by 1 H, 13 CNMR, COSY, NOESY, HSQC, HMBC and HRMS.…”

Section: Miscellaneousmentioning

confidence: 99%

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Chemical constituents of the plants of the genus Cleistanthus and their biological activity

Pinho

Kijjoa

2007

Phytochem Rev

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Chemical examinations of Cleistanthus collinus Roxb., a poisonous tree from India, and Cleistanthus patulus Muell. Arg. have resulted in isolation of a number of arylnaphthalide lignans and their glycosides as well as some furofuranoid lignans. While Cleistanthus gracilis Hook. f. from Thailand afforded an unusual glucoside of 2-b-hydroxy-8-azabicyclo-(5,0,2)-4b, 9b-epoxynona-5,7-diene, C. schlechteri from South Africa was the first reported source of the pimarane diterpenes. Cleistanthin A and cleistanthin B, diphyllin glycosides isolated from C. collinus were reported to exhibit cytotoxicity on several cancer cell lines. Cleistanthin A was found to cause DNA strand breaks and induce apoptosis in cultured cells while cleistanthin B caused G1 arrest and induced apoptosis in mammalian cells.

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An unusual glucoside from Cleistanthus gracilis

Cited by 10 publications

References 12 publications

Antioxidant and antimicrobial activity and potential of heather (Erica spp.) extracts in the control of Listeria monocytogenes

Antioxidant and antimicrobial activity and potential of heather (Erica spp.) extracts in the control of Listeria monocytogenes

Julbernardia paniculata and Pterocarpus angolensis: From Ethnobotanical Surveys to Phytochemical Characterization and Bioactivities Evaluation

Chemical constituents of the plants of the genus Cleistanthus and their biological activity

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