An Unusual Presentation of Primary Hyperparathyroidism: Pathological Fracture

Abstract

Primary hyperparathyroidism revealed by a pathological fracture is very uncommon. We present a case of a 54-year-old female patient who was admitted with fracture of her right femur. She underwent closed intramedullary reconstruction nailing with bipolar locking. The pathological findings confirmed the diagnosis of primary hyperparathyroidism with brown tumor. Further tests showed increased both calcium level and PTH level. A parathyroidectomy was performed. She made an uneventful recovery and was discharged to home.

Recurrent pathological fractures in osteitis fibrosa cystica: a case of undetected primary hyperparathyroidism due to parathyroid adenoma

“…These are known as 'brown tumours'. Brown tumours are benign hypervascular focal lesions in bones caused by increased osteoclastic activity and fibroblastic proliferation [6]. They are seen commonly in facial bones, mandible, sternum, pelvis, ribs, femurand rarely in vertebrae [6].…”

“…Brown tumours are benign hypervascular focal lesions in bones caused by increased osteoclastic activity and fibroblastic proliferation [6]. They are seen commonly in facial bones, mandible, sternum, pelvis, ribs, femurand rarely in vertebrae [6]. Even though pathological fractures in PHPT are relatively uncommon [7], areas of bone with brown tumours are vulnerable to fractures with trivial trauma.…”

Multiple Brown Tumors and Pathologic Patellar Fracture in a Patient With Secondary Hyperparathyroidism

“…Primary HPT is usually treated successfully by parathyroidectomy. [14][15][16][17] Secondary HPT is corrected by medical treatment to replenish or amend serum calcium and phosphorous levels to regulate elevated PTH levels. Oral calcium supplements should be taken along with limited dietary phosphorus consumption and phosphate binding antacids.…”

Unusual pathological fracture of the clavicle revealing primary hyperparathyroidism: a case report

“…The occurrence of bone lesions such as pathologic fractures in PHPT is now very rare since methods to measure serum calcium became available routinely in the mid-1970s [ 2 ].…”