An updated cohort mortality study of workers exposed to styrene in the reinforced plastics and composites industry.

Abstract

Mortality data have been updated for a further 12 years for a cohort ofworkers in the reinforced plastics and composites industry with exposures to styrene monomer and other chemicals. The

Cancer incidence among Finnish workers exposed to aromatic hydrocarbons

“…A previous study has reported a similar increase for substantial exposure to styrene (OR 4.1, 90% CI 1.4±12, 5 cases) [30]. The previous cohort studies on styrene [17,20,24,37] have not reported in detail the risk of this primary site. We cannot rule out, however, the possibility that the excess in our data was an artefact related to multiple comparisons or correlations with some unknown occupational factors.…”

“…The pooled summary RR [13] for a cumulative exposure of ³ 100 ppm´years was 1.93 (95% CI 1.04±3.59) as based on 21 exposed cases. In the large United States study there were ®ve cases involving a cumulative exposure of ³100 ppm´years, respectively (SMR 1.06) [37]. The smaller study in the United States did not report the site-speci®c SMR for the pancreas [24].…”

Mortality patterns among workers exposed to styrene in the reinforced plastic boatbuilding industry: An update

“…Statistically significant excess overall mortality generally has been found only among short-term workers, employed less than 1 year [Wong et al, 1994;Kolstad et al, 1995;Boffetta et al, 1998]. This mortality excess does not appear to be related to styrene exposure.…”

Possible Reproductive Toxicity of Styrene in Peripubertal Male Mice.

“…The biomedical effects of styrene have been studied both experimentally and epidemiologically. There are extensive publications on the mutagenicity and carcinogenicity [2][3][4][5][6]. Recently, migration of styrene from thermoset polyester cookware into foods has been studied during normal cooking applications, with testing for 2 h at 175°C into olive oil resulting in significantly higher migration of styrene than seen for other foods [7] .…”