An updated mortality study of workers at a petroleum refinery in Beaumont, Texas

Raabe, Gerhard K.; Collingwood, Kim W.; Wong, Otto

doi:10.1002/(sici)1097-0274(199801)33:1<61::aid-ajim8>3.3.co;2-7

Cited by 5 publications

(10 citation statements)

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“…Likewise, other comparable occupational cohorts employed in US refineries and petrochemical plants showed significantly decreased mortality rates in comparison with the national and state population (Divine et al, 1999; Lewis et al, 2000; Satin et al, 2002). Furthermore, Marsh et al (1991), Raabe et al (1998), Wong et al (2001a, 2001b) and Tsai et al (1997, 2003) found no changes in mortality for DM among workers with both refinery and chemical plant experience compared to the national population.…”

Section: Resultsmentioning

confidence: 88%

Occupational chemical exposure and diabetes mellitus risk

et al. 2016

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Diabetes mellitus (DM) is a group of metabolic diseases that may originate from an interaction between genetic and lifestyle risk factors. However, the possible role of occupational chemical exposures in the disease development and progression remains unclear. Therefore, this review aimed to provide a comprehensive evaluation of the relationship between occupational exposure to specific chemical substances or industrial activities and DM morbidity and mortality outcomes. Although some positive findings may support the diabetogenic role of certain pesticides and dioxins in different workplaces, the variable conditions of exposure, the lack of quantitative environmental or biological monitoring data and the different outcomes evaluated do not allow defining a specific exposure-disease causality. Therefore, further epidemiological studies will be necessary to adequately assess modes of action for different substances, dose-response relationships as well as individual susceptibility factors potentially affecting the exposure-disease continuum. Overall, this appears important to adequately assess, communicate and manage risks in occupational chemical exposure settings with the aim to protect workers and build healthier job conditions for diabetic employees.

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Section: Resultsmentioning

confidence: 88%

Occupational chemical exposure and diabetes mellitus risk

et al. 2016

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“…Divine et al 57 identified a significant excess of 'other leukemias' (SMR 252) in the Houston, Texas refinery, although total leukemias and more prevalent lymphatic/hematopoietic disease subtypes such as AML, chronic myelogenous leukemia, acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL) were not significantly changed, nor were they related to higher exposure job types. Raabe et al 56 reported a and New Jersey (Bayway), and related analyses identified increased leukemias (SMR 154) and excess CLL (SMR 183). 60 Gamble et al 62 reported excess NHL and MM (SMR 137).…”

Section: Resultsmentioning

confidence: 99%

An evidence-based analysis of epidemiologic associations between lymphatic and hematopoietic cancers and occupational exposure to gasoline

Keenan¹,

Gaffney²,

Ronk³

et al. 2013

Hum Exp Toxicol

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The presence of benzene in motor gasoline has been a health concern for potential increased risk of acute myelogenous leukemia and perhaps other lymphatic/hematopoietic cancers for approximately 40 years. Because of the widespread and increasing use of gasoline by consumers and the high exposure potential of occupational cohorts, a thorough understanding of this issue is important. The current study utilizes an evidence-based approach to examine whether or not the available epidemiologic studies demonstrate a strong and consistent association between occupational exposure to gasoline and lymphatic/hematopoietic cancers. Among 67 epidemiologic studies initially identified, 54 were ranked according to specific criteria relating to the relevance and robustness of each study for answering the research question. The 30 highest-ranked studies were sorted into three tiers of evidence and were analyzed for strength, specificity, consistency, temporality, dose-response trends and coherence. Meta statistics were also calculated for each general and specific lymphatic/hematopoietic cancer category with adequate data. The evidence-based analysis did not confirm any strong and consistent association between occupational exposure to gasoline and lymphatic/hematopoietic cancers based on the epidemiologic studies available to date. These epidemiologic findings, combined with the evidence showing relatively low occupational benzene vapor exposures associated with gasoline formulations during the last three decades, suggest that current motor gasoline formulations are not associated with increased lymphatic/hematopoietic cancer risks related to benzene.

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“…In studies conducted by industry or industry consultants, 25–31 essentially no statistically significant increase of malignant melanoma was found in workers in petrochemical plants. Many reports have pointed out the flaws and biases in these industry‐conducted studies.…”

Section: Introductionmentioning

confidence: 93%

Causal Relationship from Exposure to Chemicals in Oil Refining and Chemical Industries and Malignant Melanoma

Mehlman

2006

Annals of the New York Academy of Sciences

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Malignant melanoma has been thought to be related mainly to exposure to the sun or radiation. A review of the scientific literature reveals many significant correlations between benzene and benzene-containing solvents in the workplace and the occurrence of malignant melanoma, particularly in sites that have never been exposed to sunlight. A comparison of positive correlations between such exposure and malignant melanoma by independent investigators and negative findings by investigators with industry affiliations reveals that this difference, at least in part, may account for the discrepant findings. Based on independent studies, it is reasonable to conclude that malignant melanoma is causally related to employment-related chemical exposures in the petroleum refining industry.

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An updated mortality study of workers at a petroleum refinery in Beaumont, Texas

Cited by 5 publications

References 0 publications

Occupational chemical exposure and diabetes mellitus risk

Occupational chemical exposure and diabetes mellitus risk

An evidence-based analysis of epidemiologic associations between lymphatic and hematopoietic cancers and occupational exposure to gasoline

Causal Relationship from Exposure to Chemicals in Oil Refining and Chemical Industries and Malignant Melanoma

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