Anabolic Steroids Impair the Exercise-Induced Growth of the Cardiac Capillary Bed

Tagarakis, Christos V. M.; Bloch, Wilhelm; Hartmann, G.; Hollmann, W; Addicks, Klaus

doi:10.1055/s-2000-3835

Cited by 35 publications

(21 citation statements)

References 45 publications

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“…It is likely that this could be the cause of fatal arrhythmia in athletes who use AAS. Two reports investigated the cardiac capillary bed of testosterone-propionate administered female rats [34,35]. Although they observed the impairment of cardiac capillaries by AAS, they did not report of any obstructions in the myocardial or pericardial region.…”

Section: Discussionmentioning

confidence: 99%

Endocrinological and Pathological Effects of Anabolic-androgenic Steroid in Male Rats

2004

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Abstract. Many athletes use drugs, especially anabolic androgenic steroids (AAS), but there are few reports on the endocrinological and pathological changes in AAS abusers. In this study we reported the results of endocrinological examinations in rats administered AAS and also physical changes. We separated 37 male Wistar rats (7 weeks old) into 3 groups: Group A was medicated with nandrolone decanoate, metenolone acetate, and dromostanolone; Group B with nandrolone decanoate and saline; and Group C was given only saline. They were given subcutaneous injections of the medications or the control vehicle once a week for 6 weeks. Medications were stopped for 4 weeks, and then resumed for another 6 weeks. After that, rats were sacrificed. Serum testosterone level in Group A was significantly higher than that in Group C. Serum dihydrotestosterone in Group A was significantly higher than that in both Groups B and C. Serum estradiol-17b levels in Groups A and B were significantly higher than that in Group C. In pathological evaluation, heart, testis, and adrenal gland were severely damaged. These findings indicate that there is a high degree of risk related to the use of AAS.

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Section: Discussionmentioning

confidence: 99%

Endocrinological and Pathological Effects of Anabolic-androgenic Steroid in Male Rats

2004

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“…Tagarakis et al [19] reveal in their work that athletes who use AAS have an increase in the heart's microvascularization, but this increase does not accompany the hypertrophy induced by physical training. This causes an imbalance between supply and the demand of oxygen in the myocardium, especially during aerobic physical training, becoming a side effect of AAS.…”

Section: Discussionmentioning

confidence: 99%

Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats

et al. 2014

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“…Some studies demonstrate a role of endothelial-derived factors that cause hyperpolarization of potassium channels on smooth muscle cells during administration of AS [30]. The AS can also inhibit the effects of nitric oxide, inducing vasospasm [31].…”

Section: Cardiovascular Complicationsmentioning

confidence: 99%

Anabolic steroids: dependence and complications of chronic use

et al. 2009

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Anabolic steroids are widely used for doping, in professional and domestic sports. The mechanism of action is not completely understood. It may differ somewhat depending on the specific molecule due to structural differences that influence the specificity of binding with steroid receptors. When used by athletes in training, they can improve performance to levels that cannot be attained by almost any combination of sophisticated nonchemical support by modern sport science. The severity of the undesired effects of anabolic steroids depends on a variety of factors, from the type and combination of them, the dose and duration of administration, as well as the gender of the person taking the drug. Younger individuals and women show greater effects caused by anabolic steroids in terms of performance, but are also at greater risk of side effects. This paper presents a review of the literature concerning the major adverse effects of anabolic steroids, focusing the attention on possible situations of addiction from this category of drugs.

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Anabolic Steroids Impair the Exercise-Induced Growth of the Cardiac Capillary Bed

Cited by 35 publications

References 45 publications

Endocrinological and Pathological Effects of Anabolic-androgenic Steroid in Male Rats

Endocrinological and Pathological Effects of Anabolic-androgenic Steroid in Male Rats

Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats

Anabolic steroids: dependence and complications of chronic use

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