Anaesthesia of brachycephalic dogs

Downing, Frances; Gibson, Sarah R.

doi:10.1111/jsap.12948

Cited by 57 publications

(65 citation statements)

References 71 publications

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“…We believe widespread use of omeprazole and maropitant in brachycephalic dogs has been related to a previous study that concluded "medical treatment of upper GI disorders [using omeprazole and the prokinetic cisapride]… dramatically improves the prognosis following surgical treatment of brachycephalic obstructive airway disease" 38 : this conclusion has been repeated subsequently by others 39 . However, this study was a prospective case series, meaning that such conclusions could not be drawn in the absence of a control group.…”

Section: Discussionmentioning

confidence: 79%

Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

McCormack

Olley

Glanemann

et al. 2020

Sci Rep

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The proton pump inhibitor omeprazole is administered to dogs with gastroduodenal ulceration or oesophagitis, whereas the neurokinin-1 receptor antagonist maropitant citrate is licensed as an antiemetic drug. In people, omeprazole is overprescribed in hospitals, increasing the risk of adverse effects and imposing unnecessary costs in healthcare. To investigate the use of omeprazole and maropitant in our veterinary specialist hospital, we conducted a prospective observational study in its Medicine and Surgery wards, recording patient data and obtaining contemporaneous information from clinicians about their reasons for administering either drug. In doing so, we find omeprazole and maropitant are administered to a large proportion of dogs, including to many of those with no presenting signs suggestive of gastrointestinal disease. We find prescribing clinicians consider both drugs safe but often underestimate their financial cost. We find the stated reasons and objective predictors of administration of both drugs vary according to clinical setting but that these modalities yield concordant results. Reviewing the manner of administration and stated indications for use of both drugs, we find omeprazole is often administered outside dosing recommendations, and both drugs are frequently administered for aims that are unlikely to be achieved when considering their known biological effects in dogs. In conclusion, our work reveals probable overprescribing of omeprazole and maropitant citrate in hospitalised dogs, highlighting a need for initiatives to decrease inappropriate prescribing.

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Section: Discussionmentioning

confidence: 79%

Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

McCormack

Olley

Glanemann

et al. 2020

Sci Rep

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show abstract

“…A limitation of the studies evaluated is the inclusion of all breeds. Brachycephalic breeds are more susceptible to GOR due to the increase in negative intrathoracic pressure as a result of overcoming upper respiratory tract obstruction associated with brachycephalic obstructive airway syndrome (Downing and Gibson, 2018). Therefore, the inclusion of brachycephalic breeds, which is unknown in these studies may bias the results.…”

Section: Appraisal Application and Reflectionmentioning

confidence: 99%

In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?

Barry

2020

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PICO question In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Five papers were critically reviewed. There was a randomised prospective study, two randomised blinded prospective studies, randomised non-blinded prospective study and a randomised, double blinded and placebo-controlled prospective study. Strength of evidence Moderate Outcomes reported Evidence of high quality suggests omeprazole or cisapride with esomeprazole decrease the incidence of gastro-oesophageal reflux (GOR) in the anaesthetised dog. In addition, a study of lower quality showed that continuous infusion of metoclopramide at a higher than normal dose rate decreased the incidence of GOR. Conclusion Omeprazole or cisapride with esomeprazole decreases the incidence of GOR in the anaesthetised dog. How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care

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“…Os efeitos antieméticos das fenotiazinas são benéfi cos em tais associações (PAWSON, 2010; RANKIN, 2015). O principal fármaco dessa classe empregados em pequenos animais é a acepromazina RANKIN, 2015;MURREL, 2016;DOWING & GIBSON, 2018), sua dose para cães é de 0,01 a 0,1 mg/kg, pelas vias intravenosa, intramuscular ou subcutânea. O tempo para aparecimento do efeito total é de aproximadamente 30 minutos após as injeções intramusculares, mas é menor se utilizada a via intravenosa .…”

Section: Fenotiazínicosunclassified

“…jejum pré-anestésico é sempre pré-requisito para um procedimento eletivo, devido à existência de conteúdo gástrico que eleva o perigo de regurgitação no decorrer da anestesia injetável e/ou após o procedimento, sendo capaz de ocorrer aspiração via traqueal e, por consequência, o desenvolvimento de um possível quadro de pneumonia por aspiração. O recomendado é jejum alimentar de 12 horas e hídrico de duas horas, sendo que braquicefálicos possuem maior propensão a regurgitação se possuírem edema de epiglote(DOWING & GIBSON, 2018).…”

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Terapia Com Ondas De Choque (Shockwave) Na Desmite Do Ligamento Acessório Inferior (Check Ligament) Em Equino – Relato De Caso

Pereira¹,

Neto²,

Nascimento³

et al. 2019

A Produção Do Conhecimento Na Medicina Veterinária

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Anaesthesia of brachycephalic dogs

Cited by 57 publications

References 71 publications

Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?

Terapia Com Ondas De Choque (Shockwave) Na Desmite Do Ligamento Acessório Inferior (Check Ligament) Em Equino – Relato De Caso

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