Anaesthetic efficacy of intraoral topical lidocaine and prilocaine in nanostrusctured lipid nanocarriers: a randomized clinical trial

Abstract

In a randomizedplacebo-controlledcrossover trial the present study evaluated if nanostructured lipidnanocarriers (NLC) could improve the topical anaesthetic efficacy of lidocaineand prilocaine (L+P) incorporated in a xanthan-hydrogel on the oral cavity.There was no difference among topical formulations in reducing pain duringneedle insertion or local anaesthetic injection. Nonetheless, exploratoryanalyses indicate that individuals with low mechanical pain sensitivity mightbe more susceptible to placebo effects which could also interfere with theanaesthetic effects of the topical formulations. Thus, mechanical painsensitivity can be an interesting approach to increase assay sensitivity inclinical trials of topical anaesthesia.In a randomizedplacebo-controlledcrossover trial the present study evaluated if nanostructured lipidnanocarriers (NLC) could improve the topical anaesthetic efficacy of lidocaineand prilocaine (L+P) incorporated in a xanthan-hydrogel on the oral cavity.There was no difference among topical formulations in reducing pain duringneedle insertion or local anaesthetic injection. Nonetheless, exploratoryanalyses indicate that individuals with low mechanical pain sensitivity mightbe more susceptible to placebo effects which could also interfere with theanaesthetic effects of the topical formulations. Thus, mechanical painsensitivity can be an interesting approach to increase assay sensitivity inclinical trials of topical anaesthesia.