No abstract

In a randomizedplacebo-controlledcrossover trial the present study evaluated if nanostructured lipidnanocarriers (NLC) could improve the topical anaesthetic efficacy of lidocaineand prilocaine (L+P) incorporated in a xanthan-hydrogel on the oral cavity.There was no difference among topical formulations in reducing pain duringneedle insertion or local anaesthetic injection. Nonetheless, exploratoryanalyses indicate that individuals with low mechanical pain sensitivity mightbe more susceptible to placebo effects which could also interfere with theanaesthetic effects of the topical formulations. Thus, mechanical painsensitivity can be an interesting approach to increase assay sensitivity inclinical trials of topical anaesthesia.In a randomizedplacebo-controlledcrossover trial the present study evaluated if nanostructured lipidnanocarriers (NLC) could improve the topical anaesthetic efficacy of lidocaineand prilocaine (L+P) incorporated in a xanthan-hydrogel on the oral cavity.There was no difference among topical formulations in reducing pain duringneedle insertion or local anaesthetic injection. Nonetheless, exploratoryanalyses indicate that individuals with low mechanical pain sensitivity mightbe more susceptible to placebo effects which could also interfere with theanaesthetic effects of the topical formulations. Thus, mechanical painsensitivity can be an interesting approach to increase assay sensitivity inclinical trials of topical anaesthesia.

A integridade de epitélios esofágicos de suínos foi avaliada com medida de resistividade elétrica após preparo em água purificada ou salina; e armazenamento a-20 oC por 3 semanas. Foi avaliada a resistividade do epitélio fresco (n=17 para cada tipo de preparo), após descongelamento os espécimes foram reavaliados. As medidas de resistividade dos epitélios foram (mediana ± desvio interquartílico, em KΩ/cm2): água (fresco: 5,2±1,4; congelado: 2,6±2,9) e salina (fresco: 6,4±3,6; congelado: 2,4±2,2). A resistividade do epitélio esofágico foi alterada pelo congelamento (p<0,01), mas não sofreu interferência do método de preparo (p>0,05).

This research evaluated whether topical anesthetic efficacy increases on palatal mucosa pretreated with microneedles.