Analgesic activity of Amorphophallus campanulatus tuber

Shilpi, Jamil A.; Ray, Pranta; Sarder, M.M.; Uddin, Shaikh Jamal

doi:10.1016/j.fitote.2005.03.024

Cited by 34 publications

(19 citation statements)

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“…APME or APAE was used in the doses of 250 and 500 mg/kg (one tenth of the approximate LD 50 ) as mentioned in other previous studies (Shilpi et al 2005;Nataraj et al 2012). The dose of prednisolone was selected as per previous reports .…”

Section: Grouping and Treatmentsmentioning

confidence: 99%

“…The tuber of this plant has high medicinal value and consumed by many people as a food. Pharmacologically, it exhibited anti-inflammatory (De et al 2010), analgesic (Shilpi et al 2005), CNS depressant (Das et al 2009), cytotoxic (Angayarkanni et al 2007), antibacterial and antifungal (Khan et al 2008) activities in experimental studies. The tuber contains phytochemicals like b-sitosterol (Srivastava et al 2014), lupeol (Khare 2007), quercetin, gallic acid (Nataraj et al 2009;Nataraj et al 2012), and betulinic acid (Tandan & Sharma 2013).…”

Section: Introductionmentioning

confidence: 99%

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Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Dey

Sharma

Wanjari

et al. 2016

Pharmaceutical Biology

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Context: The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders. Objective: The present study evaluated the effects of extracts of Amorphophallus paeoniifolius tubers on acetic acid-induced ulcerative colitis (UC) in rats. Materials and methods: Wistar rats were orally administered methanol extract (APME) or aqueous extract (APAE) (250 and 500 mg/kg) or standard drug, prednisolone (PRDS) (4 mg/kg) for 7 days. On 6th day of treatment, UC was induced by transrectal instillation of 4% acetic acid (AA) and after 48 h colitis was assessed by measuring colitis parameters, biochemical estimations and histology of colon. Results: APME or APAE pretreatment significantly (p < .05-.001) prevented AA-induced reduction in body weight and increase in colitis parameters viz. stool consistency, colon weight/length ratio and ulcer score, area and index. Extracts treatment attenuated (p < .001) increase in alkaline phosphatase and lactate dehydrogenase in serum and myeloperoxidase activity and cytokines in colon tissue due to AA administration. Extracts treatment prevented AA-induced elevation in lipid peroxidation and decline in activities of superoxide dismutase and catalase and reduced-glutathione content (p < .05-.001) along with histopathological alterations. PRDS also showed similar ameliorative effect on colitis. Discussion and conclusion: APME and APAE showed a preventive effect on UC, and ameliorated inflammation and oxidative damage in colon. The effects may be attributed to presence of phytochemicals, betulinic acid, b-sitosterol, and glucomannan. In conclusion, the tuber of Amorphophallus paeoniifolius exhibited an anticolitic effect through anti-inflammatory and antioxidant action. ARTICLE HISTORY

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Section: Grouping and Treatmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Dey

Sharma

Wanjari

et al. 2016

Pharmaceutical Biology

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“…A. oncophyllus juga mampu menghambat p r o s e s k a r s i n o g e n e s i s . M e k a n i s m e penghambatan karsinogenesis melalui p e n u r u n a n k a d a r k o l e s t e r o l d a n kemampuannya mengikat asam empedu untuk dikeluarkan bersama feses (Shilpi, 2005;Dipayana dan Prasetyo, 2006;Ansil, et al, 2012;.…”

Section: Manfaat Dan Nilai Iles-ilesunclassified

PELUANG BUDIDAYA ILES-ILES (Amorphophallus spp.) SEBAGAI TANAMAN SELA DI PERKEBUNAN KARET

Afifah¹,

Oktorina²,

Setiono³

2014

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AbstrakIles-iles merupakan umbi-umbian yang memiliki potensi ekonomi cukup tinggi. Salah satu negara tujuan ekspor hasil umbi ini adalah Jepang. Jepang membutuhkan tepung atau gaplek iles-iles lebih dari 1.000 ton/tahun. Bagian tanaman iles-iles yang dimanfaatkan adalah umbinya. Salah satu komponen penyusun umbi iles-iles adalah karbohidrat yang terdiri atas pati, glukomanan, serat kasar, dan gula bebas. Glukomanan merupakan serat larut alam (soluble fiber). Umbi iles-iles dimanfaatkan di industri non-pangan. Daerah yang telah membudidayakan tanaman iles-iles dalam skala yang luas adalah Propinsi Jawa Timur di areal konsesi tanaman jati. Kondisi agroklimat tanaman karet yang sudah berumur 4 tahun hampir sama dengan kondisi agroklimat tanaman jati. Oleh karena itu, tanaman iles-iles sesuai untuk ditanam sebagai tanaman sela di lahan perkebunan karet, dan dapat menambah pendapatan petani karet. Mulai umur 4 tahun, areal di bawah tajuk perkebunan karet sudah mulai ternaungi 50%. Hal ini sesuai dengan syarat tumbuh tanaman iles-iles yang mutlak ditanam di bawah naungan minimal 50%. Suhu udara di bawah pohon karet juga optimal untuk tanaman ilesiles (22°C -30°C). Jika di lahan perkebunan karet dengan populasi 550 pohon per hektar, maka dapat ditanam kurang lebih 5.000 tanaman iles-iles. Umbi yang akan dihasilkan sekitar 10 ton -15 ton per hektar pada tahun ketiga. Jika umbi dijual segar, petani karet akan memperoleh tambahan penghasilan 25 -37,5 juta per ha pada tahun ketiga.Kata Kunci: Iles-iles (Amorphophallus spp.), tanaman sela, perkebunan karet. Abstract Iles-iles (Amorphophallus spp.) are tuber crops that have high economic potential. One of these commodities export destinations is Japan. Japan needs more than 1000 tons/year of iles-iles flour. One of the components of the iles-iles tuber is a carbohydrate consisting of starch, glucomannan, crude fiber, and sugar-free. Glucomannan is a natural soluble fiber. Areas that have been cultivating iles-iles in a broad scale is the Province of East Java in teak plant concession areas. Agroclimatic conditions of 4 years old rubber plants is

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“…It is also used in piles and given as the restorative in dyspepsia debility, anti-inflammatory, anti-haemorrhoidal, haemostatic, expectorant and anthelmintic. [22][23][24] A. campanulatus has been reported for its potential actions such as hepatoprotective, [25][26][27][28] antioxidant, [27][28][29][30][31][32][33][34][35] antitumor, [35] analgesic, [36][37][38] in-vitro cytotoxic, antibacterial, antifungal, [39][40][41][42][43] anthelmintics, [44,45] anti-inflammatory, [38,46] curative effect, [47] gastro protective, [48,49] antidiarrhoeal, [50] immunomodulatory, [51] central nervous system activities. [52][53][54] From plant mainly isolated quercetin, [25] 3,5-diacetyltambulin, [40] amblyone, [41] salviasperanol.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Amorphophallus campanulatus tuber extracts against H₂O₂induced oxidative damage in human erythrocytes and leucocytes

Bais¹,

Mali²

2013

Int J Green Pharm

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Background: Amorphophallus companulatus (Araceae) is a tuberous medicinal plant commonly used in Ayuvedic medicines as well as tribal medicines of India. Aim: Aim of the present study was to investigate the protective effect of A. companulatus tuber extracts against H 2 O 2 induced oxidative damage in human erythrocytes and leucocytes. Setting and Design: The experiment was set and design as per available method in the literatures. Three measurements were performed under each set of extracts. Materials and Methods: The extracts of tuber of A. companulatus such as methanol, ethanol, acetone (70%) and hydro-alcohol (1:1) used to assess catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH) and lipid peroxidation (LPO) levels of human erythrocytes and leucocytes. Statistical Analysis: All experimental data were statistically analysed and expressed as means ± SD by using the one-way analysis of variance. Results: Results of present studies revealed that, increased in the CAT, SOD, GPx and reduction of GSH and LPO levels in H 2 O 2 group compared with control group. The extracts of tuber of A. companulatus treated groups showed effective reduction of CAT, SOD, GPx and increased the GSH and LPO levels as compared with H 2 O 2 group on human erythrocytes and leucocytes. The methanol extract was found more effective than others. Conclusion: The present findings suggest that, the extracts of tuber of A. companulatus possess protective effect against H 2 O 2 induced oxidative damage. Furthermore, these tuber extracts may appeared to be beneficial in preventing H 2 O 2 oxidative human red blood cell (RBC) damage in human and can improve RBC membrane permanence. The tubers of A. companulatus are the potential source of natural antioxidants for the treatment and prevention of disease in which LPO takes place.

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Analgesic activity of Amorphophallus campanulatus tuber

Cited by 34 publications

References 1 publication

Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

PELUANG BUDIDAYA ILES-ILES (Amorphophallus spp.) SEBAGAI TANAMAN SELA DI PERKEBUNAN KARET

Protective effect of Amorphophallus campanulatus tuber extracts against H₂O₂induced oxidative damage in human erythrocytes and leucocytes

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Analgesic activity of Amorphophallus campanulatus tuber

Cited by 34 publications

References 1 publication

Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

PELUANG BUDIDAYA ILES-ILES (Amorphophallus spp.) SEBAGAI TANAMAN SELA DI PERKEBUNAN KARET

Protective effect of Amorphophallus campanulatus tuber extracts against H2O2induced oxidative damage in human erythrocytes and leucocytes

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Product

Resources

About

Protective effect of Amorphophallus campanulatus tuber extracts against H₂O₂induced oxidative damage in human erythrocytes and leucocytes