Analgesic Effect Of Dioclenol And Dioflorin Isolated From Dioclea Grandiflora

Abstract

The analgesic activity of dioflorin and dioclenol, two constituents of Dioclea grandiflora Mart., has been studied in mice. It was found that dioclenol (10 mg/kg, i.p.) and dioclenol (10 mg/kg, i.p.) were effective in the acetic acid-induced writhing and tail immersion tests. These observations suggest that dioflorin and dioclenol possesses central antinociceptive activity.

Stilbenes as κ-Selective, Non-nitrogenous Opioid Receptor Antagonists

“… 11 − 17 The non-nitrogenous compound dioflorin ( 4 ), a prenylated flavonoid, was isolated from the Brazilian vine Dioclea grandiflora through activity-guided fractionation 18 − 20 and shown to have analgesic activity. 21 More extensive efforts to categorize the opioid receptor binding of dioflorin have not yet been reported. Bioassays with a series of other natural flavonoids including catechin ( 5 ) and hesperetin ( 6 ) have been conducted and demonstrate that this scaffold may have considerable potential for development of opioid receptor ligands.…”

Utilizing Nature as a Source of New Probes for Opioid Pharmacology

“…Dioflorin and dioclenol were isolated from Dioclea grandiflora Mart. (Leguminosae) [81,82] and were assessed in mice in the acetic acid-induced writhing and tail immersion tests [83]. Both compounds displayed analgesic activity that is thought to be centrally mediated by opioid receptors [83].…”

Toxicidade Aguda em Ratos Wistar Tratados com o Extrato Etanólico de Dioclea grandiflora Mart. Ex Benth (Fabaceae) (EEDg)

“…O seu principal constituinte, diocleína, tem um efeito analgésico significativo em roedores 13 , e um efeito vasorrelaxante no endotélio da aorta de rato 14 . A triagem farmacológica também revelou a atividade antinoceptiva de dioclenol e dioflorin em camundongos 15 . Um estudo foi realizado com uma outra parte da planta, as vagens, e relatou atividade antinoceptiva eficaz em camundongos 16 .…”