Analgesic Effect of Intrathecal Melissa officinalis in the Rat Model of Hot-Water and Formalin-Induced Pain

Rastegarian, A.; Abedi, Heidarali; Jahromi, Hossein Kargar; Zarei, Sanaz; Nematollahi, Arash; Mansouri, Esrafil; Sameni, Hadi

doi:10.1016/j.jams.2019.11.001

Cited by 8 publications

(2 citation statements)

References 25 publications

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“…The resultant compounds revealed analgesic effect in rat models [51] Phenolic compounds EtOH solutions -Anti-insomnia effect was observed in the enriched phenolic extracts [52] Phenolic compounds EtOH solutions Room temperature The ethanolic extract displayed a reduction effect on glucose levels in rats [53] Rosmarinic acid and salvianolic acids Methanolic solutions (70%) 37 • C The resultant extracts exhibited visible GSK-3β-inhibitory activity [23] Rosmarinic acid EtOH solutions (70%) -…”

Section: Phenolic Compoundsmentioning

confidence: 99%

A Perspective on Missing Aspects in Ongoing Purification Research towards Melissa officinalis

Castro-Muñoz

Boczkaj

Cabezas

2023

Foods

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Melissa officinalis L. is a medicinal plant used worldwide for ethno-medical purposes. Today, it is grown everywhere; while it is known to originate from Southern Europe, it is now found around the world, from North America to New Zealand. The biological properties of this medicinal plant are mainly related to its high content of phytochemical (bioactive) compounds, such as flavonoids, polyphenolic compounds, aldehydes, glycosides and terpenes, among many other groups of substances. Among the main biological activities associated with this plant are antimicrobial activity (against fungi and bacteria), and antispasmodic, antioxidant and insomnia properties. Today, this plant is still used by society (as a natural medicine) to alleviate many other illnesses and symptoms. Therefore, in this perspective, we provide an update on the phytochemical profiling analysis of this plant, as well as the relationships of specific biological and pharmacological effects of specific phytochemicals. Currently, among the organic solvents, ethanol reveals the highest effectiveness for the solvent extraction of precious components (mainly rosmarinic acid). Additionally, our attention is devoted to current developments in the extraction and fractionation of the phytochemicals of M. officinalis, highlighting the ongoing progress of the main strategies that the research community has employed. Finally, after analyzing the literature, we suggest potential perspectives in the field of sustainable extraction and purification of the phytochemical present in the plant. For instance, some research gaps concern the application of cavitation-assisted extraction processes, which can effectively enhance mass transfer while reducing the particle size of the extracted material in situ. Meanwhile, membrane-assisted processes could be useful in the fractionation and purification of obtained extracts. On the other hand, further studies should include the application of ionic liquids and deep eutectic solvents (DES), including DESs of natural origin (NADES) and hydrophobic DESs (hDES), as extraction or fractionating solvents, along with new possibilities for effective extraction related to DESs formed in situ, assisted by mechanical mixing (mechanochemistry-based approach).

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Section: Phenolic Compoundsmentioning

confidence: 99%

A Perspective on Missing Aspects in Ongoing Purification Research towards Melissa officinalis

Castro-Muñoz

Boczkaj

Cabezas

2023

Foods

View full text Add to dashboard Cite

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“…Plants high in natural chemicals such as polyphenols, tocopherols, flavonoids, alkaloids, tannins, carotenoids, and terpenoids have been extensively explored in recent years due to their significant immunomodulatory, anticarcinogenic, and antioxidant capabilities. M. officinalis (MO) (lemon balm, Lamiaceae family) is a well-known traditional medicinal plant species used in the treatment of numerous ailments; it is also commonly eaten as a vegetable, adding flavour to recipes [ 6 ]. M. Officinalis is an excellent source of natural antioxidants; its leaves contain numerous phytochemicals, including polyphenolic components such as caffeic acid derivatives, imeric compounds, flavonoids, essential oil, and copious citral.…”

Section: Introductionmentioning

confidence: 99%

Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats

Kawara,

Moawed,

Elsenosi

et al. 2024

BMC Complement Med Ther

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Background Melissa officinalis (MO) is a well-known medicinal plant species used in the treatment of several diseases; it is widely used as a vegetable, adding flavour to dishes. This study was designed to evaluate the therapeutic effect of MO Extract against hyperthyroidism induced by Eltroxin and γ-radiation. Methods Hyperthyroidism was induced by injecting rats with Eltroxin (100 µg/kg/ day) for 14 days and exposure to γ-radiation (IR) (5 Gy single dose). The hyperthyroid rats were orally treated with MO extract (75 mg/kg/day) at the beginning of the second week of the Eltroxin injection and continued for another week. The levels of thyroid hormones, liver enzymes and proteins besides the impaired hepatic redox status and antioxidant parameters were measured using commercial kits. The hepatic gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein-1(Keap-1) in addition to hepatic inflammatory mediators including tumor necrosis factor-α (TNF- α), Monocyte chemoattractant protein-1 (MCP-1) and fibrogenic markers such as transforming growth factor-beta1 (TGF-β1) were determined. Results MO Extract reversed the effect of Eltroxin + IR on rats and attenuated the thyroid hormones. Moreover, it alleviated hyperthyroidism-induced hepatic damage by inhibiting the hepatic enzymes’ activities as well as enhancing the production of proteins concomitant with improving cellular redox homeostasis by attenuating the deranged redox balance and modulating the Nrf2/Keap-1 pathway. Additionally, MO Extract alleviated the inflammatory response by suppressing the TNF- α and MCP-1 and prevented hepatic fibrosis via Nrf2-mediated inhibition of the TGF-β1/Smad pathway. Conclusion Accordingly, these results might strengthen the hepatoprotective effect of MO Extract in a rat model of hyperthyroidism by regulating the Nrf-2/ Keap-1 pathway.

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Therapeutic applications of lemon balm (Melissa officinalis) for obstetrics and gynecological health issues: A systematic review

Alimoradi,

Jafari,

Abdi

et al. 2023

Journal of Herbal Medicine

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Analgesic Effect of Intrathecal Melissa officinalis in the Rat Model of Hot-Water and Formalin-Induced Pain

Cited by 8 publications

References 25 publications

A Perspective on Missing Aspects in Ongoing Purification Research towards Melissa officinalis

A Perspective on Missing Aspects in Ongoing Purification Research towards Melissa officinalis

Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats

Therapeutic applications of lemon balm (Melissa officinalis) for obstetrics and gynecological health issues: A systematic review

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