This paper assesses the performance of Highway Safety Manual (HSM) predictive models when applied to Brazilian highways. The study evaluates five rural multilane highways and calculates calibration factors (Cx) of 2.62 for all types of crashes and 2.35 for Fatal or Injury (FI) crashes. The Goodness of Fit measures show that models for all types of crashes perform better than FI crashes. Additionally, the paper assesses the application of the calibrated prediction model to the atypical year of 2020, in which the COVID-19 pandemic altered traffic patterns worldwide. The HSM method was applied to 2020 using the Cx obtained from the four previous years. Results show that for 2020, the observed counts were about 10% lower than the calibrated predictive model estimate of crash frequency for all types of crashes, while the calibrated prediction of FI crashes was very close to the observed counts. The findings of this study demonstrate the usefulness of HSM predictive models in identifying high-risk areas or situations and improving road safety, contributing to making investment decisions in infrastructure and road safety more sustainable.